Get Up to Speed on Many Types of Adaptive DesignsSince the publication of the first edition, there have been remarkable advances in the methodology and application of adaptive trials. Incorporating many of these new developments, Adaptive Design Theory and Implementation Using SAS and R, Second Edition offers a detailed framework to understand the

This edited volume is a definitive text on adaptive clinical trial designs from creation and customization to utilization. As this book covers the full spectrum of topics involved in the adaptive designs arena, it will serve as a valuable reference for researchers working in industry, government and academia. The target audience is anyone involved in the planning and execution of clinical trials, in particular, statisticians, clinicians, pharmacometricians, clinical operation specialists, drug supply managers, and infrastructure providers. In spite of the increased efficiency of adaptive trials in saving costs and time, ultimately getting drugs to patients sooner, their adoption in clinical development is still relatively low. One of the chief reasons is the higher complexity of adaptive design trials as compared to traditional trials. Barriers to the use of clinical trials with adaptive features include the concerns about the integrity of study design and conduct, the risk of regulatory non-acceptance, the need for an advanced infrastructure for complex randomization and clinical supply scenarios, change management for process and behavior modifications, extensive resource requirements for the planning and design of adaptive trials and the potential to relegate key decision makings to outside entities. There have been limited publications that address these practical considerations and recommend best practices and solutions. This book fills this publication gap, providing guidance on practical considerations for adaptive trial design and implementation. The book comprises three parts: Part I focuses on practical considerations from a design perspective, whereas Part II delineates practical considerations related to the implementation of adaptive trials. Putting it all together, Part III presents four illustrative case studies ranging from description and discussion of specific adaptive trial design considerations to the logistic and regulatory issues faced in trial implementation. Bringing together the expertise of leading key opinion leaders from pharmaceutical industry, academia, and regulatory agencies, this book provides a balanced and comprehensive coverage of practical considerations for adaptive trial design and implementation.

After decades spent pondering basic questions about adopting or implementing ‘best practices’ in education, educators have assembled a canon of evidence-based strategies and programs that should consistently produce good outcomes. So why is the work of educating students still such challenging work for so many? The best, most skilled educators adapt programs every day to meet the changing needs of their students. One size does not fit all, and one textbook, teaching strategy, or program will never meet the needs of all teachers and learners. Adaptive Implementation: Navigating the School Improvement Landscape focuses on how practitioners and researchers together continue to improve their craft by systematically collecting data on adaptations, testing them out, and figuring out what works. We provide a framework for building an adaptive implementation process in education, with tools and templates for practitioners to use. In the end, we hope that this book sparks a dialogue among educators as they continue to create adaptive implementation processes that work for their context.

Adaptive design has become an important tool in modern pharmaceutical research and development. Compared to a classic trial design with static features, an adaptive design allows for the modification of the characteristics of ongoing trials based on cumulative information. Adaptive designs increase the probability of success, reduce costs and the t

Subband adaptive filtering is rapidly becoming one of the most effective techniques for reducing computational complexity and improving the convergence rate of algorithms in adaptive signal processing applications. This book provides an introductory, yet extensive guide on the theory of various subband adaptive filtering techniques. For beginners, the authors discuss the basic principles that underlie the design and implementation of subband adaptive filters. For advanced readers, a comprehensive coverage of recent developments, such as multiband tap–weight adaptation, delayless architectures, and filter–bank design methods for reducing band–edge effects are included. Several analysis techniques and complexity evaluation are also introduced in this book to provide better understanding of subband adaptive filtering. This book bridges the gaps between the mixed–domain natures of subband adaptive filtering techniques and provides enough depth to the material augmented by many MATLAB® functions and examples. Key Features: Acts as a timely introduction for researchers, graduate students and engineers who want to design and deploy subband adaptive filters in their research and applications. Bridges the gaps between two distinct domains: adaptive filter theory and multirate signal processing. Uses a practical approach through MATLAB®-based source programs on the accompanying CD. Includes more than 100 M-files, allowing readers to modify the code for different algorithms and applications and to gain more insight into the theory and concepts of subband adaptive filters. Subband Adaptive Filtering is aimed primarily at practicing engineers, as well as senior undergraduate and graduate students. It will also be of interest to researchers, technical managers, and computer scientists.

This monograph is focused on control law design methods for asymptotic tracking and disturbance rejection in the presence of uncertainties. The methods are based on adaptive implementation of the Internal Model Principle (IMP). The monograph shows how this principle can be applied to the problems of asymptotic rejection/tracking of a priori uncertain exogenous signals for linear and nonlinear plants with known and unknown parameters. The book begins by introducing the problems of adaptive control, the challenges that are faced, modern methods and an overview of the IMP. It then introduces special observers for uncertain exogeneous signals affecting linear and nonlinear systems with known and unknown parameters. The basic algorithms of adaptation applied to the canonical closed-loop error models are presented. The authors then address the systematic design of adaptive systems for asymptotic rejection/tracking of a priori uncertain exosignals. The monograph also discusses the adaptive rejection/tracking of a priori uncertain exogenous signals in systems with input delay, the problems of performance improvement in disturbance rejection and reference tracking and the issue of robustness of closed-loop systems. Adaptive Regulation provides a systematic discussion of the IMP applied to a variety of control problems, making it of interest to researchers and industrial practitioners.

Partial-update adaptive signal processing algorithms not only permit significant complexity reduction in adaptive filter implementations, but can also improve adaptive filter performance in telecommunications applications. This book gives state-of-the-art methods for the design and development of partial-update adaptive signal processing algorithms for use in systems development.Partial-Update Adaptive Signal Processing provides a comprehensive coverage of key partial updating schemes, giving detailed information on the theory and applications of acoustic and network echo cancellation, channel equalization and multiuser detection. It also examines convergence and stability issues for partial update algorithms, providing detailed complexity analysis and a unifying treatment of partial-update techniques.Features:• Advanced analysis and design tools• Application examples illustrating the use of partial-update adaptive signal processing• MATLAB codes for developed algorithms This unique reference will be of interest to signal processing and communications engineers, researchers, R&D engineers and graduate students."This is a very systematic and methodical treatment of an adaptive signal processing topic, of particular significance in power limited applications such as in wireless communication systems and smart ad hoc sensor networks. I am very happy to have this book on my shelf, not to gather dust, but to be consulted and used in my own research and teaching activities" – Professor A. G. Constantinides, Imperial College, LondonAbout the author:Kutluyil Dogançay is an associate professor of Electrical Engineering at the University of South Australia. His research interests span statistical and adaptive signal processing and he serves as a consultant to defence and private industry. He was the Signal Processing and Communications Program Chair of IDC Conference 2007, and is currently chair of the IEEE South Australia Communications and Signal Processing Chapter. - Advanced analysis and design tools - Algorithm summaries in tabular format - Case studies illustrate the application of partial update adaptive signal processing