The U.S. Department of Energy (DOE) promotes scientific and technological innovation to advance the national, economic, and energy security of the United States. Recognizing the potential of microorganisms to offer new energy alternatives and remediate environmental contamination, DOE initiated the Genomes to Life program, now called Genomics: GTL, in 2000. The program aims to develop a predictive understanding of microbial systems that can be used to engineer systems for bioenergy production and environmental remediation, and to understand carbon cycling and sequestration. This report provides an evaluation of the program and its infrastructure plan. Overall, the report finds that GTL's research has resulted in and promises to deliver many more scientific advancements that contribute to the achievement of DOE's goals. However, the DOE's current plan for building four independent facilities for protein production, molecular imaging, proteome analysis, and systems biology sequentially may not be the most cost-effective, efficient, and scientifically optimal way to provide this infrastructure. As an alternative, the report suggests constructing up to four institute-like facilities, each of which integrates the capabilities of all four of the originally planned facility types and focuses on one or two of DOE's mission goals. The alternative infrastructure plan could have an especially high ratio of scientific benefit to cost because the need for technology will be directly tied to the biology goals of the program.

Throughout the world, closely related species are found on landmasses separated by wide stretches of ocean. What explains these far-flung distributions? Why are such species found where they are across the Earth? Since the discovery of plate tectonics, scientists have conjectured that plants and animals were scattered over the globe by riding pieces of ancient supercontinents as they broke up. In the past decade, however, that theory has foundered, as the genomic revolution has made reams of new data available. And the data has revealed an extraordinary, stranger-than-fiction story that has sparked a scientific upheaval. In The Monkey’s Voyage, biologist Alan de Queiroz describes the radical new view of how fragmented distributions came into being: frogs and mammals rode on rafts and icebergs, tiny spiders drifted on storm winds, and plant seeds were carried in the plumage of sea-going birds to create the map of life we see today. In other words, these organisms were not simply constrained by continental fate; they were the makers of their own geographic destiny. And as de Queiroz shows, the effects of oceanic dispersal have been crucial in generating the diversity of life on Earth, from monkeys and guinea pigs in South America to beech trees and kiwi birds in New Zealand. By toppling the idea that the slow process of continental drift is the main force behind the odd distributions of organisms, this theory highlights the dynamic and unpredictable nature of the history of life. In the tradition of John McPhee’s Basin and Range, The Monkey’s Voyage is a beautifully told narrative that strikingly reveals the importance of contingency in history and the nature of scientific discovery.

Talks about the ubiquitous computing that helps us to identify ways of managing care that promises to be considerably easier in letting patients maintain their good health while enjoying their life in their usual social setting, rather than having to spend much time at costly, dedicated healthcare facilities.

This book combines the experience of 225 experts on 900 pages. Scientists worldwide are currently overwhelmed by the ever-increasing number and diversity of genome projects. This handbook is your guide through the jungle of new methods and techniques available to analyse gene expression - the first to provide such a broad view of the measurement of mRNA and protein expression in vitro, in situ and even in vivo. Despite this broad approach, detail is sufficient for you to grasp the principles behind each method. In each case, the authors weigh up the advantages and disadvantages, paying particular attention to the automated, high-throughput processing demanded by the biotech industry. Completely up to date, the book covers such ground-breaking methods such as DNA microarrays, serial analysis of gene expression, differential display, and identification of open reading frame expressed sequence tags. All the methods and necessary equipment are presented visually in more than 300 mainly colour illustrations to assist their step-by-step reproduction in your laboratory. Each chapter is rounded off with its own set of extensive references that provide access to detailed experimental protocols. In short, the bible of analysing gene expression.

This volume explores problems in the history of science at the intersection of life sciences and agriculture, from the mid-eighteenth to the mid-twentieth century. Taking a comparative national perspective, the book examines agricultural practices in a broad sense, including the practices and disciplines devoted to land management, forestry, soil science, and the improvement and management of crops and livestock. The life sciences considered include genetics, microbiology, ecology, entomology, forestry, and deal with US, European, Russian, Japanese, Indonesian, Chinese contexts. The book shows that the investigation of the border zone of life sciences and agriculture raises many interesting questions about how science develops. In particular it challenges one to re-examine and take seriously the intimate connection between scientific development and the practical goals of managing and improving – perhaps even recreating – the living world to serve human ends. Without close attention to this zone it is not possible to understand the emergence of new disciplines and transformation of old disciplines, to evaluate the role and impact of such major figures of science as Humboldt and Mendel, or to appreciate how much of the history of modern biology has been driven by national ambitions and imperialist expansion in competition with rival nations.