The study of the brain continues to expand at a rapid pace providing fascinating insights into the basic mechanisms underlying nervous system illnesses. New tools, ranging from genome sequencing to non-invasive imaging, and research fueled by public and private investment in biomedical research has been transformative in our understanding of nervous system diseases and has led to an explosion of published primary research articles. Diseases of the Nervous System, Second Edition, summarizes the current state of basic and clinical knowledge for the most common neurological and neuropsychiatric conditions. In a systematic progression, each chapter covers either a single disease or a group of related disorders ranging from static insults to primary and secondary progressive neurodegenerative diseases, neurodevelopmental illnesses, illnesses resulting from nervous system infection and neuropsychiatric conditions. Chapters follow a common format and are stand-alone units, each covering disease history, clinical presentation, disease mechanisms and treatment protocols. Dr. Sontheimer also includes two chapters which discuss common concepts shared among the disorders and how new findings are being translated from the bench to the bedside. In a final chapter, he explains the most commonly used neuroscience jargon. The chapters address controversial issues in current day neuroscience research including translational research, drug discovery, ethical issues, and the promises of personalized medicine. This new edition features new chapters on Pain and Addiction to highlight the growing opioid crisis and the ethical issue of prescriptions drug abuse. This book provides an introduction for course adoption and an introductory tutorial for students, scholars, researchers and medical professionals interested in learning the state of the art concerning our understanding and treatment of diseases of the nervous system. Each chapter includes suggested further readings and/or journal club recommendations. - 2016 PROSE Award winner of the Best Textbook Award in Biological and Life Sciences - Provides a focused tutorial introduction to the core diseases of the nervous system - Includes comprehensive introductions to Stroke, Epilepsy, Alzheimer's Disease, Parkinson's Disease, Huntington's Disease, ALS, Head and Spinal Cord Trauma, Multiple Sclerosis, Brain Tumors, Depression, Schizophrenia and many other diseases of the nervous system - Covers more than 40 diseases from the foundational science to the best treatment protocols - Includes discussions of translational research, drug discovery, personalized medicine, ethics, and neuroscience - New Edition features two new chapters on Pain and Addiction

This single-volume reference covers the natural course, treatment, and management of all neurological diseases affecting the brain, spinal cord nerves and muscles. This comprehensive text reference seeks to assist physicians with treatment by providing an easy-to-use compendium covering the treatment and management of all neurological diseases along with details on the natural course of these diseases. Organized for ease of use and quick reference, each chapter presents a neurological disorder or key symptoms and systematically discusses the clinical syndrome and differential diagnosis, natural course, principles of therapy, and practical management of each. Covers wide range of neurological conditions and potential treatments, including the evidence for and against each treatment Describes the spontaneous course of neurological diseases along with discussion of the management of different stages and variants of a disorder Presents special situations and exceptional cases in which alternative therapies should be considered

The third edition of this classic text, extensively revised, is now available in paperback, priced so that all interested physicians can have their own copy. The autonomic nervous system regulates, without conscious awareness, the function of the heart and all other bodily organs. Autonomic failure can cause a variety of seemingly strange symptoms, which may present to general physicians or a wide spectrum of specialists. This book shows how these symptoms can be studied scientifically in order to reach a precise diagnosis and instigate rational treatment.

The Mouse Nervous System provides a comprehensive account of the central nervous system of the mouse. The book is aimed at molecular biologists who need a book that introduces them to the anatomy of the mouse brain and spinal cord, but also takes them into the relevant details of development and organization of the area they have chosen to study. The Mouse Nervous System offers a wealth of new information for experienced anatomists who work on mice. The book serves as a valuable resource for researchers and graduate students in neuroscience. Systematic consideration of the anatomy and connections of all regions of the brain and spinal cord by the authors of the most cited rodent brain atlases A major section (12 chapters) on functional systems related to motor control, sensation, and behavioral and emotional states A detailed analysis of gene expression during development of the forebrain by Luis Puelles, the leading researcher in this area Full coverage of the role of gene expression during development and the new field of genetic neuroanatomy using site-specific recombinases Examples of the use of mouse models in the study of neurological illness

This textbook provides a comprehensive overview of the currently used concepts, approaches and technologies in the discovery and development of new treatments for the full spectrum of disorders of the central nervous system. It guides the reader through all essential steps, from finding an innovative idea, to the registration of a new drug. Divided into four sections, the book starts by presenting a broad perspective on current approaches in central nervous system (CNS) drug discovery. The second section addresses the generation of ideas for the identification of targets and novel treatment strategies; covers core functions in early discovery, and provides an example of a novel treatment paradigm: brain stimulation. The third section highlights strategies and technologies in translational CNS drug discovery. In an effort to bridge the gap between discovery and clinical development, it also covers brain imaging, EEG and cognitive testing approaches. The fourth section extensively discusses the clinical phase of drug development, covering the basics of early clinical testing for psychopharmacological drugs. The book’s final chapter addresses the registration for newly developed drugs. Written by experts from academia and industry, the book covers important basics and best practices, as well as recent developments in drug discovery. Offering in-depth insights into the world of drug development, it represents essential reading for early researchers who want to prepare for a career in drug discovery in academia or industry.

This unique textbook deals with the variations in the causes, presentations and treatment of neurological disease throughout human populations. International Neurology is an indispensable guide to the full range of neurological conditions you will see in your ever-changing patient population. Comprehensive coverage of neurological diseases and disorders with a clinical approach to diagnosis, treatment and management Truly international authorship distils expert knowledge from around the world Succinct, bite-sized, templated chapters allow for rapid clinical referral Further reading recommendations for each chapter guide readers requiring more depth of information Endorsed by the World Federation of Neurology

This novel title explores the central and peripheral nervous system in health and disease. By first establishing a fundamental basic science knowledge about the cellular elements of the nervous system, the reader is then presented with clinical cases in a pathophysiologic manner, as exemplified in unifying Guillain Barre and Multiple Sclerosis in one chapter on Demyelinating Disease. The reader is encouraged to adopt a systematic approach of sorting out neurologic problems he or she may face in clinical practice by identifying time and space factors based on the age of a patient. High quality illustrations for each case are included in the book along with novel three-dimensional reconstructions of MR, PET, and CT data whenever possible. Developed largely for medical students as an introduction to the clinical neurosciences, for neurology residents, and for others doing graduate level neuroscience study, Neurology - A Modern, Pathophysiologic Approach to the Diagnosis and Treatment of Neurologic Disease will also be of significant interest to the established neurologist as a comprehensive, up-to-date reference.