Global advances in medicine, food, water, energy, microelectronics, communications, defense, and other important sectors of the economy are increasingly driven by discoveries in nanoscience and the development of nanotechnologies. Engaging the nanoscience and technology community in the crafting of national priorities, developing novel approaches for translating fundamental discovery to a technology readiness level appropriate for venture/industry funding, increasing domestic student interest in nanoscience to expand the workforce pipeline, and exploring new ways of coordinating the work of the National Nanotechnology Initiative (NNI) are all imperatives if the United States is to fully reap the societal benefits of nanotechnology. A Quadrennial Review of the National Nanotechnology Initiative provides a framework for a redesign of the NNI and its coordination with the goal of achieving a U.S. resurgence in nanotechnology. This report makes recommendations to improve the value of the NNI's research and development strategy and portfolio to the economic prosperity and national security of the United States.

Nanoscale science, engineering, and technology, often referred to simply as "nanotechnology," is the understanding, characterization, and control of matter at the scale of nanometers, the dimension of atoms and molecules. Advances in nanotechnology promise new materials and structures that are the basis of solutions, for example, for improving human health, optimizing available energy and water resources, supporting a vibrant economy, raising the standard of living, and increasing national security. Established in 2001, the National Nanotechnology Initiative (NNI) is a coordinated, multiagency effort with the mission to expedite the discovery, development, and deployment of nanoscale science and technology to serve the public good. This report is the latest triennial review of the NNI called for by the 21st Century Nanotechnology Research and Development Act of 2003. It examines and comments on the mechanisms in use by the NNI to advance focused areas of nanotechnology towards advanced development and commercialization and on the physical and human infrastructure needs for successful realization in the United States of the benefits of nanotechnology development.

Nanotechnology has become one of the defining ideas in global R&D over the past decade. In 2001 the National Nanotechnology Initiative (NNI) was established as the U.S. government interagency program for coordinating nanotechnology research and development across deferral agencies and facilitating communication and collaborative activities in nanoscale science, engineering, and technology across the federal government. The 26 federal agencies that participate in the NNI collaborate to (1) advance world-class nanotechnology research and development; (2) foster the transfer of new technologies into products for commercial and public benefit; (3) develop and sustain educational resources, a skilled workforce and the supporting infrastructure and tools to advance nanotechnology; and (4) support the responsible development of nanotechnology. As part of the third triennial review of the National Nanotechnology Initiative, the Committee on Triennial Review of the National Nanotechnology Initiative: Phase II was asked to provide advice to the Nanoscale Science, Engineering, and Technology (NSET) Subcommittee and the National Nanotechnology Coordination Office in three areas: Task 1 - Examine the role of the NNI in maximizing opportunities to transfer selected technologies to the private sector, provide an assessment of how well the NNI is carrying out this role, and suggest new mechanisms to foster transfer of technologies and improvements to NNI operations in this area where warranted. Task 2 - Assess the suitability of current procedures and criteria for determining progress towards NNI goals, suggest definitions of success and associated metrics, and provide advice on those organizations (government or non-government) that could perform evaluations of progress. Task 3 - Review NNI's management and coordination of nanotechnology research across both civilian and military federal agencies. Interim Report for the Triennial Review of the National Nanotechnology Initiative, Phase II offers initial comment on the committee's approach to Task 2 and offers initial comments on the current procedures and criteria for determining progress toward and achievement of the desired outcomes.

The National Nanotechnology Initiative (NNI) was created in 2000 to focus and coordinate the nanoscience and nanotechnology research and development (R&D) activities being funded by several federal agencies. The purpose of the NNI is to marshal these research activities in order to accelerate responsible development and deployment of nanotechnology for economic benefit and national security. To take stock of the progress of the NNI, Congress, in P. L. 108-153, the 21st Century Nanotechnology Research and Development Act, directed the National Research Council to carry out a review of the program every three years. This report presents the results of the first of those reviews, which addresses the economic impact of nanotechnology developments and provides a benchmark of U.S. R&D efforts relative to those undertaken by foreign competitors. In addition, the report offers an assessment of the current status of responsible development of nanotechnology and comments on the feasibility of molecular self-assembly.

Nanoscale science and technology, often referred to as "nanoscience" or "nanotechnology," are science and engineering enabled by our relatively new ability to manipulate and characterize matter at the level of single atoms and small groups of atoms. This capability is the result of many developments in the last two decades of the 20th century, including inventions of scientific instruments like the scanning tunneling microscope. Using such tools, scientists and engineers have begun controlling the structure and properties of materials and systems at the scale of 10?9 meters, or 1/100,000 the width of a human hair. Scientists and engineers anticipate that nanoscale work will enable the development of materials and systems with dramatic new properties relevant to virtually every sector of the economy, such as medicine, telecommunications, and computers, and to areas of national interest such as homeland security. Indeed, early products based on nanoscale technology have already found their way into the marketplace and into defense applications. In 1996, as the tremendous scientific and economic potential of nanoscale science and technology was beginning to be recognized, a federal interagency working group formed to consider creation of a national nanotechnology initiative (NNI). As a result of this effort, around $1 billion has been directed toward NNI research since the start of FY 2001. At the request of officials in the White House National Economic Council and agencies that are participating in NNI, the National Research Council (NRC) agreed to review the NNI. The Committee for the Review of the National Nanotechnology Initiative was formed by the NRC and asked to consider topics such as the current research portfolio of the NNI, the suitability of federal investments, and interagency coordination efforts in this area.

The rapid commercialization of nanotechnology is one of the most intriguing industrial phenomena of our time. But as the universe of applied nanotechnology is burgeoning, so are questions raised about the possible impact of exposure to nanoscale materials on human health and the environment. This book offers the most current and authoritative look at the regulatory, governance, and business issues of a technology that is as fascinating as it is challenging.