This research paper presents a neutrosophic mathematical representation of the elements of the digital image by dividing the points of the digital picture matrix into neutrosophic sets (PNS - Picture Neutrosophic Set), and studying the degree of connection between the points of the digital image for us to reach to the connected neutrosophic sets. We have also introduced many mathematical theories and results to calculate the difference and dissimilarity between the neutrosophic sets, which contributes practically in the comparison between digital images and their different uses. Our results help mainly to upgrade and create new neutrosophic algorithms for searching inside images and videos databases.

In this study, a new edge detection method based on Neutrosophic Set (NS) struc- ture via using maximum norm entropy (EDA-MNE) is proposed.

“Neutrosophic Sets and Systems” has been created for publications on advanced studies in neutrosophy, neutrosophic set, neutrosophic logic, neutrosophic probability, neutrosophic statistics that started in 1995 and their applications in any field, such as the neutrosophic structures developed in algebra, geometry, topology, etc. Some articles in this issue: n-Refined Neutrosophic Modules, A Neutrosophic Approach to Digital Images, A Novel Method for Neutrosophic Assignment Problem by using Interval-Valued Trapezoidal Neutrosophic Number.

“Neutrosophic Sets and Systems” has been created for publications on advanced studies in neutrosophy, neutrosophic set, neutrosophic logic, neutrosophic probability, neutrosophic statistics that started in 1995 and their applications in any field, such as the neutrosophic structures developed in algebra, geometry, topology, etc. Neutrosophy is a new branch of philosophy that studies the origin, nature, and scope of neutralities, as well as their interactions with different ideational spectra. This theory considers every notion or idea together with its opposite or negation and with their spectrum of neutralities in between them (i.e. notions or ideas supporting neither nor ). The and ideas together are referred to as . Neutrosophy is a generalization of Hegel's dialectics (the last one is based on and only). According to this theory every idea tends to be neutralized and balanced by and ideas - as a state of equilibrium. In a classical way , , are disjoint two by two. But, since in many cases the borders between notions are vague, imprecise, Sorites, it is possible that , , (and of course) have common parts two by two, or even all three of them as well. Neutrosophic Set and Neutrosophic Logic are generalizations of the fuzzy set and respectively fuzzy logic (especially of intuitionistic fuzzy set and respectively intuitionistic fuzzy logic).

Neutrosophic Sets and Systems (NSS) is an academic journal, published quarterly online and on paper, that has been created for publications of advanced studies in neutrosophy, neutrosophic set, neutrosophic logic, neutrosophic probability, neutrosophic statistics etc. and their applications in any field.

Neutrosophic Set in Medical Image Analysis gives an understanding of the concepts of NS, along with knowledge on how to gather, interpret, analyze and handle medical images using NS methods. It presents the latest cutting-edge research that gives insight into neutrosophic set's novel techniques, strategies and challenges, showing how it can be used in biomedical diagnoses systems. The neutrosophic set (NS), which is a generalization of fuzzy set, offers the prospect of overcoming the restrictions of fuzzy-based approaches to medical image analysis. - Introduces the mathematical model and concepts of neutrosophic theory and methods - Highlights the different techniques of neutrosophic theory, focusing on applying the neutrosophic set in image analysis to support computer- aided diagnosis (CAD) systems, including approaches from soft computing and machine learning - Shows how NS techniques can be applied to medical image denoising, segmentation and classification - Provides challenges and future directions in neutrosophic set based medical image analysis

Diabetic retinopathy (DR) is considered as one of the global diseases of blindness, especially for aged people. The main reason behind this disease is the complication of diabetes in retinal blood vessels. Usually, the early warning signs are not observed. Screening is an important key for the diagnosis of early stages of diabetic retinopathy. In this work, a new technique for automatically screening three categories; Normal, Non-Proliferative Diabetic Retinopathy (Non-PDR), and Proliferative Diabetic Retinopathy (PDR) disease is presented that is may help doctors and physicians to make a preliminary decision.