Michael Kasler was born 1758 in the province of Hess, Germany. He immigrated to America ca. 1866 as a Hessian soldier. Michael married Susanna Minkler sometime prior to the year 1788. They lived in Vermont and were the parents of three known children. Descendants lived in Ohio, Vermont, Michigan, West Virginia and elsewhere.

This book provides information on a wide variety of issues ranging from genetics to clinical description of the syndromes, genetic testing and counseling, and clinical management including surveillance, surgical and prophylactic interventions, and chemoprevention. Moreover, current hot issues, such as the identification of novel causal genes and the challenges we face, and the relevance of cancer risk modifiers, both genetic and environmental, are also discussed. This reference book is great for geneticists, oncologists, genetic counselors, researchers, clinicians, surgeons and nurses dedicated to, or interested in, hereditary cancer. The best and most recognized experts in the field have contributed to this project, guaranteeing updated information, accuracy and the discussion of topical issues.

This book presents the proceedings of the 13th International Conference on Application of Fuzzy Systems and Soft Computing (ICAFS 2018), held in Warsaw, Poland on August 27–28, 2018. It includes contributions from diverse areas of soft computing such as uncertain computation, Z-information processing, neuro-fuzzy approaches, evolutionary computing and others. The topics of the papers include theory of uncertainty computation; theory and application of soft computing; decision theory with imperfect information; neuro-fuzzy technology; image processing with soft computing; intelligent control; machine learning; fuzzy logic in data analytics and data mining; evolutionary computing; chaotic systems; soft computing in business, economics and finance; fuzzy logic and soft computing in the earth sciences; fuzzy logic and soft computing in engineering; soft computing in medicine, biomedical engineering and the pharmaceutical sciences; and probabilistic and statistical reasoning in the social and educational sciences. The book covers new ideas from theoretical and practical perspectives in economics, business, industry, education, medicine, the earth sciences and other fields. In addition to promoting the development and application of soft computing methods in various real-life fields, it offers a useful guide for academics, practitioners, and graduates in fuzzy logic and soft computing fields.

This book focuses on the basic aspects of dental stem cells (DSCs) as well as their clinical applications in tissue engineering and regenerative medicine. It opens with a discussion of classification, protocols, and properties of DSCs and proceeds to explore DSCs within the contexts of cryopreservation; epigenetics; pulp, periodontal, tooth, bone, and corneal stroma regeneration; neuronal properties, mesenchymal stem cells and biomaterials; and as sources of hepatocytes for liver disease treatment. The fifteen expertly authored chapters comprehensively examine possible applications of DSCs and provide invaluable insights into mechanisms of growth and differentiation. Dental Stem Cells: Regenerative Potential draws from a wealth of international perspectives and is an essential addition to the developing literature on dental stem cells. This installment of Springer’s Stem Cell Biology and Regenerative Medicine series is indispensable for biomedical researchers interested in bioengineering, dentistry, tissue engineering, regenerative medicine, cell biology and oncology.