A Modern Framework Based on Time-Tested Material A Functional Analysis Framework for Modeling, Estimation and Control in Science and Engineering presents functional analysis as a tool for understanding and treating distributed parameter systems. Drawing on his extensive research and teaching from the past 20 years, the author explains how functional analysis can be the basis of modern partial differential equation (PDE) and delay differential equation (DDE) techniques. Recent Examples of Functional Analysis in Biology, Electromagnetics, Materials, and Mechanics Through numerous application examples, the book illustrates the role that functional analysis—a classical subject—continues to play in the rigorous formulation of modern applied areas. The text covers common examples, such as thermal diffusion, transport in tissue, and beam vibration, as well as less traditional ones, including HIV models, uncertainty in noncooperative games, structured population models, electromagnetics in materials, delay systems, and PDEs in control and inverse problems. For some applications, computational aspects are discussed since many problems necessitate a numerical approach.

The aim of this book is to provide methods and algorithms for the optimization of input signals so as to estimate parameters in systems described by PDE’s as accurate as possible under given constraints. The optimality conditions have their background in the optimal experiment design theory for regression functions and in simple but useful results on the dependence of eigenvalues of partial differential operators on their parameters. Examples are provided that reveal sometimes intriguing geometry of spatiotemporal input signals and responses to them. An introduction to optimal experimental design for parameter estimation of regression functions is provided. The emphasis is on functions having a tensor product (Kronecker) structure that is compatible with eigenfunctions of many partial differential operators. New optimality conditions in the time domain and computational algorithms are derived for D-optimal input signals when parameters of ordinary differential equations are estimated. They are used as building blocks for constructing D-optimal spatio-temporal inputs for systems described by linear partial differential equations of the parabolic and hyperbolic types with constant parameters. Optimality conditions for spatially distributed signals are also obtained for equations of elliptic type in those cases where their eigenfunctions do not depend on unknown constant parameters. These conditions and the resulting algorithms are interesting in their own right and, moreover, they are second building blocks for optimality of spatio-temporal signals. A discussion of the generalizability and possible applications of the results obtained is presented.

This book addresses controller and estimator design for systems that vary both spatially and in time: systems like fluid flow, acoustic noise and flexible structures. It includes coverage of the selection and placement of actuators and sensors for such distributed-parameter systems. The models for distributed parameter systems are coupled ordinary/partial differential equations. Approximations to the governing equations, often of very high order, are required and this complicates both controller design and optimization of the hardware locations. Control system and estimator performance depends not only on the controller/estimator design but also on the location of the hardware. In helping the reader choose the best location for actuators and sensors, the analysis provided in this book is crucial because neither intuition nor trial-and-error is foolproof, especially where multiple sensors and actuators are required, and moving hardware can be difficult and costly. The mechatronic approach advocated, in which controller design is integrated with actuator location, can lead to better performance without increased cost. Similarly, better estimation can be obtained with carefully placed sensors. The text shows how proper hardware placement varies depending on whether, disturbances are present, whether the response should be reduced to an initial condition or whether controllability and/or observability have to be optimized. This book is aimed at non-specialists interested in learning controller design for distributed-parameter systems and the material presented has been used for student teaching. The relevant basic systems theory is presented and followed by a description of controller synthesis using lumped approximations. Numerical algorithms useful for efficient implementation in real engineering systems and practical computational challenges are also described and discussed.

The field of uncertainty quantification is evolving rapidly because of increasing emphasis on models that require quantified uncertainties for large-scale applications, novel algorithm development, and new computational architectures that facilitate implementation of these algorithms. Uncertainty Quantification: Theory, Implementation, and Applications provides readers with the basic concepts, theory, and algorithms necessary to quantify input and response uncertainties for simulation models arising in a broad range of disciplines. The book begins with a detailed discussion of applications where uncertainty quantification is critical for both scientific understanding and policy. It then covers concepts from probability and statistics, parameter selection techniques, frequentist and Bayesian model calibration, propagation of uncertainties, quantification of model discrepancy, surrogate model construction, and local and global sensitivity analysis. The author maintains a complementary web page where readers can find data used in the exercises and other supplementary material.

A Practical Guide to Geometric Regulation for Distributed Parameter Systems provides an introduction to geometric control design methodologies for asymptotic tracking and disturbance rejection of infinite-dimensional systems. The book also introduces several new control algorithms inspired by geometric invariance and asymptotic attraction for a wid

This book presents, in a methodical way, updated and comprehensive descriptions and analyses of some of the most relevant problems in the context of fluid-structure interaction (FSI). Generally speaking, FSI is among the most popular and intriguing problems in applied sciences and includes industrial as well as biological applications. Various fundamental aspects of FSI are addressed from different perspectives, with a focus on biomedical applications. More specifically, the book presents a mathematical analysis of basic questions like the well-posedness of the relevant initial and boundary value problems, as well as the modeling and the numerical simulation of a number of fundamental phenomena related to human biology. These latter research topics include blood flow in arteries and veins, blood coagulation and speech modeling. We believe that the variety of the topics discussed, along with the different approaches used to address and solve the corresponding problems, will help readers to develop a more holistic view of the latest findings on the subject, and of the relevant open questions. For the same reason we expect the book to become a trusted companion for researchers from diverse disciplines, such as mathematics, physics, mathematical biology, bioengineering and medicine.

Closes the gap between bioscience and mathematics-based process engineering This book presents the most commonly employed approaches in the control of bioprocesses. It discusses the role that control theory plays in understanding the mechanisms of cellular and metabolic processes, and presents key results in various fields such as dynamic modeling, dynamic properties of bioprocess models, software sensors designed for the online estimation of parameters and state variables, and control and supervision of bioprocesses Control in Bioengineering and Bioprocessing: Modeling, Estimation and the Use of Sensors is divided into three sections. Part I, Mathematical preliminaries and overview of the control and monitoring of bioprocess, provides a general overview of the control and monitoring of bioprocesses, and introduces the mathematical framework necessary for the analysis and characterization of bioprocess dynamics. Part II, Observability and control concepts, presents the observability concepts which form the basis of design online estimation algorithms (software sensor) for bioprocesses, and reviews controllability of these concepts, including automatic feedback control systems. Part III, Software sensors and observer-based control schemes for bioprocesses, features six application cases including dynamic behavior of 3-dimensional continuous bioreactors; observability analysis applied to 2D and 3D bioreactors with inhibitory and non-inhibitory models; and regulation of a continuously stirred bioreactor via modeling error compensation. Applicable across all areas of bioprocess engineering, including food and beverages, biofuels and renewable energy, pharmaceuticals and nutraceuticals, fermentation systems, product separation technologies, wastewater and solid-waste treatment technology, and bioremediation Provides a clear explanation of the mass-balance–based mathematical modelling of bioprocesses and the main tools for its dynamic analysis Offers industry-based applications on: myco-diesel for implementing "quality" of observability; developing a virtual sensor based on the Just-In-Time Model to monitor biological control systems; and virtual sensor design for state estimation in a photocatalytic bioreactor for hydrogen production Control in Bioengineering and Bioprocessing is intended as a foundational text for graduate level students in bioengineering, as well as a reference text for researchers, engineers, and other practitioners interested in the field of estimation and control of bioprocesses.