The 500 Years of Resistance Comic Book is a powerful and historically accurate graphic portrayal of Indigenous resistance to the European colonization of the Americas, beginning with the Spanish invasion under Christopher Columbus and ending with the Six Nations land reclamation in Ontario in 2006. Gord Hill spent two years unearthing images and researching historical information to create The 500 Years of Resistance Comic Book, which presents the story of Aboriginal resistance in a far-reaching format. Other events depicted include the 1680 Pueblo Revolt in New Mexico; the Inca insurgency in Peru from the 1500s to the 1780s; Pontiac and the 1763 Rebellion and Royal Proclamation; Geronimo and the 1860s Seminole Wars; Crazy Horse and the 1877 War on the Plains; the rise of the American Indian Movement in the 1960s; 1973's Wounded Knee; the Mohawk Oka Crisis in Quebec in 1990; and the 1995 Aazhoodena/Stoney Point resistance. With strong, plain language and evocative illustrations, The 500 Years of Resistance Comic Book documents the fighting spirit and ongoing resistance of Indigenous peoples through 500 years of genocide, massacres, torture, rape, displacement, and assimilation; a necessary antidote to the conventional history of the Americas.

An alternative and unorthodox view of the colonization of the Americas by Europeans is offered in this concise history. Eurocentric studies of the conquest of the Americas present colonization as a civilizing force for good, and the native populations as primitive or worse. Colonization is seen as a mutually beneficial process, in which ''civilization'' was brought to the natives who in return shared their land and cultures. The opposing historical camp views colonization as a form of genocide in which the native populations were passive victims overwhelmed by European military power. In this fresh examination, an activist and historian of native descent argues that the colonial powers met resistance from the indigenous inhabitants and that these confrontations shaped the forms and extent of colonialism. This account encompasses North and South America, the development of nation-states, and the resurgence of indigenous resistance in the post-World War II era.

An alternative and unorthodox view of the colonization of the Americas by Europeans is offered in this concise history. Eurocentric studies of the conquest of the Americas present colonization as a civilizing force for good, and the native populations as primitive or worse. Colonization is seen as a mutually beneficial process, in which "civilization” was brought to the natives who in return shared their land and cultures. The opposing historical camp views colonization as a form of genocide in which the native populations were passive victims overwhelmed by European military power. In this fresh examination, an activist and historian of native descent argues that the colonial powers met resistance from the indigenous inhabitants and that these confrontations shaped the forms and extent of colonialism. This account encompasses North and South America, the development of nation-states, and the resurgence of indigenous resistance in the post-World War II era.