Extremophiles have been studied for many decades - these microorganisms can thrive under a vast range of conditions, including extreme temperature, pH, pressure, radiation, salinity, energy, and nutrient limitation. Life in extreme environments has evolved to render solutions that overcome the challenges presented by such conditions. Among these solutions include extremozymes and extremolytes, an invaluable collection of natural, renewable, and biological resources with immense potential for applications aimed at the development of a sustainable bio-economy, especially in biotechnology and other industrial sectors. In line with this observation, extremophilic DNA polymerases have been instrumental in driving unprecedented progress in recombinant DNA technologies applied in diverse areas, including agriculture and human health. Thermostable and halotolerant enzymes are likely to feature significantly in the renewable energy sector of the future, including bioethanol production and the Gas-to-Liquid effort, which aims at converting greenhouse gases such as CO2 and methane to liquid fuels. Furthermore, due to the stability of extremophilic protein homologs, insights to the structure and function of protein/protein complexes, including those critical to protein degradation, were solved to advance our understanding of fundamental processes across the three domains of life.

Physiological and Biotechnological Aspects of Extremophiles highlights the current and topical areas of research in this rapidly growing field. Expert authors from around the world provide the latest insights into the mechanisms of these fascinating organisms use to survive.The vast majority of extremophiles are microbes which include archaea, bacteria and some eukaryotes. These microbes live under chemical and physical extremes that are usually lethal to cellular molecules, yet they manage to survive and even thrive. Extremophiles have important practical uses. They are a valuable source of industrially important enzymes and recent research has revealed novel mechanisms and biomolecular structures with a broad range of potential applications in biotechnology, biomining, and bioremediation.Aimed at research scientists, students, microbiologists, and biotechnologists, this book is an essential reading for scientists working with extremophiles and a recommended reference text for anyone interested in the microbiology, bioprospecting, biomining, biofuels, and extremozymes of these organisms. - Shows the implications of the physiological adaptations of microbes from extreme habitats that are largely contributed by their biomolecules from basic to applied research - Provides in-depth knowledge of genomic plasticity and proteome of different extremophiles - Gives detailed and comprehensive insight about use of genetic engineering as well as genome editing for industrial applications

This book explores various aspects of thermophilic and halophilic microbes from Eurasian ecosystems, which have proved to offer a unique reservoir of genetic diversity and biological source of extremophiles. It also covers the biotechnological uses of extremophiles, and their potential use in agricultural and industrial applications. The topics addressed include but are not limited to: diversity and microbial ecology, microbe-environment interactions, adaptation and evolution, element cycling and biotechnological applications of thermophiles and halophiles in Eurasian ecosystems. In order to review the progress made in biology and biotechnological applications of thermophiles and halophiles, the book combines review papers and results of original research from various specialists and authorities in the field. It includes several chapters describing the microbial diversity and ecology of geothermal springs distributed among the territory of various Eurasian countries, such as Armenia, Bulgaria, China, Georgia, India, Italy, Pakistan and Turkey. A dedicated chapter discusses selected aspects of thermophilic chemolithotrophic bacteria isolated from mining sites (sulfide ores); detailed descriptions of various thermophile microbes isolated from high-temperature environments and their biotechnological potential are also provided. Subsequent chapters describe the diversity and ecology of halophilic microbes harbored in saline and hypersaline lakes in Iran, Turkey and China; soil and plant microbiomes in saline arid lands of Uzbekistan; microbial diversity in Asian deserts; and the potential applications of thermophilic and halophilic microbes as exopolysaccharide (EPS) producers, focusing on the chemistry and applications of the EPS they produce. We hope that this book will prove valuable as an up-to-date overview of the current state of research on Eurasian extremophiles in general and thermophiles and halophiles in particular. Many questions remain unanswered, and we hope that it will stimulate further studies in this intriguing and promising field.

Many organisms in deep-sea environments are extremophiles thriving in extreme conditions: high pressure, high or low temperature, or high concentrations of inorganic compounds. This book presents the microbiology of extremophiles living in the deep sea and describes the isolation, cultivation, and taxonomic identification of microorganisms retrieved from the Mariana Trench, the world's deepest point. Also explained are techniques for recovering pressure-loving bacteria, the barophiles (piezophiles), and for whole genome analysis of Bacillus halodurans C-125. Physiological analysis of the pressure effect in Saccharomyces cerevisiae and Escherichia coli is used to answer the question of how deep-sea organisms survive under high hydrostatic pressure. These research results are useful in both basic science and industrial applications. Readers discover a new microbial world in the ocean depths, with state-of-the-science information on extremophiles.

The Desk Encyclopedia of Microbiology, Second Edition is a single-volume comprehensive guide to microbiology for the advanced reader. Derived from the six volume e-only Encyclopedia of Microbiology, Third Edition, it bridges the gap between introductory texts and specialized reviews. Covering topics ranging from the basic science of microbiology to the current "hot" topics in the field, it will be invaluable for obtaining background information on a broad range of microbiological topics, preparing lectures and preparing grant applications and reports. - The most comprehensive single-volume source providing an overview of microbiology to non-specialists - Bridges the gap between introductory texts and specialized reviews - Provides concise and general overviews of important topics within the field making it a helpful resource when preparing for lectures, writing reports, or drafting grant applications

Microbes and their biosynthetic capabilities have been invaluable in finding solutions for several intractable problems mankind has encountered in maintaining the quality of the environment. They have, for example, been used to positive effect in human and animal health, genetic engineering, environmental protection, and municipal and industrial waste treatment. Microorganisms have enabled feasible and cost-effective responses which would have been impossible via straightforward chemical or physical engineering methods. Microbial technologies have of late been applied to a range of environmental problems, with considerable success. This survey of recent scientific progress in usefully applying microbes to both environmental management and biotechnology is informed by acknowledgement of the polluting effects on the world around us of soil erosion, the unwanted migration of sediments, chemical fertilizers and pesticides, and the improper treatment of human and animal wastes. These harmful phenomena have resulted in serious environmental and social problems around the world, problems which require us to look for solutions elsewhere than in established physical and chemical technologies. Often the answer lies in hybrid applications in which microbial methods are combined with physical and chemical ones. When we remember that these highly effective microorganisms, cultured for a variety of applications, are but a tiny fraction of those to be found in the world around us, we realize the vastness of the untapped and beneficial potential of microorganisms. At present, comprehending the diversity of hitherto uncultured microbes involves the application of metagenomics, with several novel microbial species having been discovered using culture-independent approaches. Edited by recognized leaders in the field, this penetrating assessment of our progress to date in deploying microorganisms to the advantage of environmental management and biotechnology will be widely welcomed.

Despite the vital importance of the emerging area of biotechnology and its role in defense planning and policymaking, no definitive book has been written on the topic for the defense policymaker, the military student, and the private-sector bioscientist interested in the "emerging opportunities market" of national security. This edited volume is intended to help close this gap and provide the necessary backdrop for thinking strategically about biology in defense planning and policymaking. This volume is about applications of the biological sciences, here called "biologically inspired innovations," to the military. Rather than treating biology as a series of threats to be dealt with, such innovations generally approach the biological sciences as a set of opportunities for the military to gain strategic advantage over adversaries. These opportunities range from looking at everything from genes to brains, from enhancing human performance to creating renewable energy, from sensing the environment around us to harnessing its power.