This treatise offers a comprehensive exploration into the multifaceted world of bone cancer, bridging the gap between traditional medical knowledge and holistic health practices. Beginning with a historical perspective, it delves into the epidemiology and global impact of the disease, shedding light on its prevalence and societal implications. The intricate anatomy and biochemistry of bone are meticulously dissected, providing a foundational understanding of its microscopic structure, matrix, mineralization, and the biochemical markers indicative of bone turnover. The treatise further delves into the bone remodeling cycle and the complex hormonal regulation governing it. The distinction between primary and secondary bone cancers is elucidated, followed by an in-depth examination of histological classifications and the emerging realm of molecular and genetic subtypes. The genetic and epigenetic alterations driving bone tumorigenesis are discussed, along with the oncogenic pathways and environmental factors influencing disease progression. Diagnostic methodologies, from clinical examinations to advanced imaging and genetic testing, are detailed, ensuring a thorough understanding of disease identification and differential diagnosis. Treatment modalities encompass surgical approaches, chemotherapeutic regimens, radiation techniques, and the promising realm of targeted therapies. The treatise also emphasizes the importance of integrative and holistic treatment approaches, underscoring the role of nutrition, physical activity, mind-body practices, and traditional therapies in patient care. Innovative research areas, including stem cell therapy, immunotherapy, and personalized medicine, are highlighted, offering a glimpse into the future of bone cancer treatment. The treatise concludes with insights into post-treatment recovery, emphasizing physical, psychological, and social rehabilitation. "Bone Cancer Unveiled" serves as an invaluable resource for medical professionals, researchers, and anyone seeking a profound understanding of bone cancer's complexities, from its cellular origins to holistic health interventions.

This volume is devoted to the overall management of solid tumors in children. Recent advances in the use of monoclonal antibodies for diagnosis and possible treatment are presented. New approaches to the complete care of the child and family as well as specific developments in the treatment of defined conditions are discussed. A particular contribution deals with congential dysplasia of soft tissue. The material analyzed for this topic was taken from a unique collections of clinical cases supplemented by detailed laboratory studies.

Cancer cell biology research in general, and anti-cancer drug development specifically, still relies on standard cell culture techniques that place the cells in an unnatural environment. As a consequence, growing tumor cells in plastic dishes places a selective pressure that substantially alters their original molecular and phenotypic properties.The emerging field of regenerative medicine has developed bioengineered tissue platforms that can better mimic the structure and cellular heterogeneity of in vivo tissue, and are suitable for tumor bioengineering research. Microengineering technologies have resulted in advanced methods for creating and culturing 3-D human tissue. By encapsulating the respective cell type or combining several cell types to form tissues, these model organs can be viable for longer periods of time and are cultured to develop functional properties similar to native tissues. This approach recapitulates the dynamic role of cell–cell, cell–ECM, and mechanical interactions inside the tumor. Further incorporation of cells representative of the tumor stroma, such as endothelial cells (EC) and tumor fibroblasts, can mimic the in vivo tumor microenvironment. Collectively, bioengineered tumors create an important resource for the in vitro study of tumor growth in 3D including tumor biomechanics and the effects of anti-cancer drugs on 3D tumor tissue. These technologies have the potential to overcome current limitations to genetic and histological tumor classification and development of personalized therapies.

This book analyzes in detail all aspects related to endocrine and metabolic late effects observed in patients treated for cancer, both in childhood and adulthood. The chapters focusing on the possible pathogenic mechanisms of late effects (i.e., premature aging and chronic inflammation) and on bone health in cancer survivors are particularly interesting and innovative. The volume also deals with hypothalamic-pituitary, thyroid and gonadal disorders, including infertility and how to prevent it. Finally, the relationship between metabolic alterations and cardiovascular diseases in cancer survivors is addressed. Thanks to advances in cancer treatment and supportive care, the five-year survival rate of cancer patients is constantly increasing. However, this undisputable success of medicine has a flip side: the late adverse effects of anticancer therapies. Pediatric oncologists were the first to cope with late complications of treatments, but today also adult oncologists and onco-hematologists recognize the relevance of this issue. Even though late effects observed in cancer survivors can affect any organ or system, endocrine and metabolic dysfunctions are the most frequently reported. Endocrine complications rarely influence life expectancy of cancer survivors, but they can significantly impact morbidity and quality of life. Among endocrine adverse effects, severe hypothalamic damage may be considered the most harmful in survivors, leading to morbid obesity, propensity to metabolic syndrome and cardiovascular disease. This book aims to disseminate the knowledge about endocrine and metabolic adverse effects of cancer therapies and about survivorship care. Since the number of cancer survivors is steadily growing in the general population, this publication is intended not only for endocrinologists but also for oncologists, onco-hematologists, internists, pediatric specialists in those areas and general practitioners, with the aim to better counsel and monitor cancer survivors.

Drug Repurposing in Cancer Therapy: Approaches and Applications provides comprehensive and updated information from experts in basic science research and clinical practice on how existing drugs can be repurposed for cancer treatment. The book summarizes successful stories that may assist researchers in the field to better design their studies for new repurposing projects. Sections discuss specific topics such as in silico prediction and high throughput screening of repurposed drugs, drug repurposing for overcoming chemoresistance and eradicating cancer stem cells, and clinical investigation on combination of repurposed drug and anticancer therapy. Cancer researchers, oncologists, pharmacologists and several members of biomedical field who are interested in learning more about the use of existing drugs for different purposes in cancer therapy will find this to be a valuable resource. - Presents a systematic and up-to-date collection of the research underpinning the various drug repurposing approaches for a quick, but in-depth understanding on current trends in drug repurposing research - Brings better understanding of the drug repurposing process in a holistic way, combining both basic and clinical sciences - Encompasses a collection of successful stories of drug repurposing for cancer therapy in different cancer types

Embark on a meticulous exploration of Ameloblastoma, a jaw tumor that unravels its enigma through the pages of this treatise. Our journey begins with an in-depth analysis of its definition and classification, delving into the historical roots of our understanding and navigating through the intricate web of epidemiological patterns. As we progress, the treatise dissects the very foundations of Ameloblastoma, unraveling the intricacies of its pathogenesis, etiology, and the complex interplay of genetic factors influencing its development. The anatomy of the oral cavity becomes a canvas for understanding how this odontogenic tumor manifests, intertwined with the captivating narrative of tooth and odontogenic tissue development. Venturing further, the treatise unveils the normal function of ameloblasts, providing insights into the microscopic features and various variants of this condition. The cellular and molecular basis, coupled with signaling pathways and the intriguing role of stem cells in tumorigenesis, is meticulously elucidated, opening a gateway to the intricate world of Ameloblastoma's molecular landscape.

Detection and characterization of bone tumors with imaging remains a big challenge for every radiologist notwithstanding the impressive progress achieved by the introduction of several new imaging modalities. Moreover, new concepts in surgical and oncological treatment of these lesions require from the radiologist appropriate and focused answers to the specifc questions asked by the referring physicians in order to choose the best therapeutic approach for the in- vidual patient. Tis comprehensive textbook describes in detail the possibilities and limits of all moda- ties, including MRI, CT, nuclear medicine and interventional radiological procedures, employed for the modern imaging of tumoral and tumor-like lesions of bone. Teir role in the diagnosis, surgical staging, biopsy and assessment of response to therapy is discussed in detail, covering all tumor subtypes as well as their specifc anatomical location.Well selected and technically imp- cable illustrations strongly enhance the didactic value of this work. I am very much indebted and grateful to the three editors: A. Mark Davies, Murali Sundaram and Steven L. J. James, world authorities in musculoskeletal radiology, for their superb scientifc achievement in preparing and editing this wonderful volume as well as for their individual ch- ters. I would also like to thank the large international group of collaborating authors, who are also widely acknowledged for their specifc expertise in the area of bone tumors, for their outstanding contributions.