Understanding Charged Aerosol Detection with High Performance Liquid Chromatography
Title | Understanding Charged Aerosol Detection with High Performance Liquid Chromatography PDF eBook |
Author | Brian John Forsatz |
Publisher | |
Pages | 160 |
Release | 2007 |
Genre | Catalysis |
ISBN |
Charged Aerosol Detection for Liquid Chromatography and Related Separation Techniques
Title | Charged Aerosol Detection for Liquid Chromatography and Related Separation Techniques PDF eBook |
Author | Paul H. Gamache |
Publisher | John Wiley & Sons |
Pages | 548 |
Release | 2017-05-30 |
Genre | Science |
ISBN | 0470937785 |
The first book devoted exclusively to a highly popular, relatively new detection technique Charged Aerosol Detection for Liquid Chromatography and Related Separation Techniques presents a comprehensive review of CAD theory, describes its advantages and limitations, and offers extremely well-informed recommendations for its practical use. Using numerous real-world examples based on contributors’ professional experiences, it provides priceless insights into the actual and potential applications of CAD across a wide range of industries. Charged aerosol detection can be combined with a variety of separation techniques and in numerous configurations. While it has been widely adapted for an array of industrial and research applications with great success, it is still a relatively new technique, and its fundamental performance characteristics are not yet fully understood. This book is intended as a tool for scientists seeking to identify the most effective and efficient uses of charged aerosol detection for a given application. Moving naturally from basic to advanced topics, the author relates fundamental principles, practical uses, and applications across a range of industrial settings, including pharmaceuticals, petrochemicals, biotech, and more. Offers timely, authoritative coverage of the theory, experimental techniques, and end-user applications of charged aerosol detection Includes contributions from experts from various fields of applications who explore CAD’s advantages over traditional HPLC techniques, as well its limitations Provides a current theoretical and practical understanding of CAD, derived from authorities on aerosol technology and separation sciences Features numerous real-world examples that help relate fundamental properties and general operational variables of CAD to its performance in a variety of conditions Charged Aerosol Detection for Liquid Chromatography and Related Separation Techniques is a valuable resource for scientists who use chromatographic techniques in academic research and across an array of industrial settings, including the biopharmaceutical, biotechnology, biofuel, chemical, environmental, and food and beverage industries, among others.
ISPE Good Practice Guide
Title | ISPE Good Practice Guide PDF eBook |
Author | Ispe |
Publisher | |
Pages | 148 |
Release | 2019-01-24 |
Genre | |
ISBN | 9781946964144 |
Characterization of Nanoparticles Intended for Drug Delivery
Title | Characterization of Nanoparticles Intended for Drug Delivery PDF eBook |
Author | |
Publisher | Springer |
Pages | 284 |
Release | 2011-08-14 |
Genre | |
ISBN | 9781607619086 |
Pharmaceutical Stress Testing
Title | Pharmaceutical Stress Testing PDF eBook |
Author | Steven W. Baertschi |
Publisher | CRC Press |
Pages | 626 |
Release | 2016-04-19 |
Genre | Medical |
ISBN | 1439801800 |
The second edition of Pharmaceutical Stress Testing: Predicting Drug Degradation provides a practical and scientific guide to designing, executing and interpreting stress testing studies for drug substance and drug product. This is the only guide available to tackle this subject in-depth. The Second Edition expands coverage from chemical stability
Analysis of Fatty Acids Using High-performance Liquid Chromatography with Charged Aerosol Detection
Title | Analysis of Fatty Acids Using High-performance Liquid Chromatography with Charged Aerosol Detection PDF eBook |
Author | Lillian Fua Jaquinod |
Publisher | |
Pages | 114 |
Release | 2013 |
Genre | |
ISBN |
A study of parameters (organic content, additives and pH of the mobile phase) to yield good separation and detection of a series of commercially available free fatty acids ranging from C12:0 (lauric acid) to C18:3 (linolenic acid) using HPLC-CAD is undertaken. Working methods using a C18 silica column were assessed by measuring the experimental limit of detection (LOD) and sensitive ranges with consideration to effects of the Charged Aerosol Detector (CAD) temperature and detector voltage. An isocratic method with high content in acetonitrile and low pH was developed that allowed the CAD detection and quantification of the less volatile fatty acids in the range of from around 1 to 5 ng/uL to over 200 ng/uL. A power fit calibration curve was necessitated since the response of the standards did not display a true linear relationship using linear regression analysis. Conditions or mobile phase additives were not found to increase detection of semi-volatile fatty acids such as lauric acid or myristic acid (C14:0). Column bleed was potentially identified as an unexpected additive that resulted in enhanced peak detection, attributed to the formation or stabilization of bigger aerosol particles. The isocratic method was tested for an olive oil standard using an acetonitrile: 0.01M TFA (96.5:3.5) mobile phase, ion voltage at -300 V, and CAD heater setting of 35°C. Using those conditions, separation and detection of major C16 to C18 fatty acids were achieved although palmitic and oleic acids were not completely resolved. The olive oil analysis showed that relative recovery of the major fatty acid components is consistent and supports the use of HPLC-CAD system for a rapid detection of fatty acids at trace levels.
Applications of Ion Chromatography for Pharmaceutical and Biological Products
Title | Applications of Ion Chromatography for Pharmaceutical and Biological Products PDF eBook |
Author | Lokesh Bhattacharyya |
Publisher | John Wiley & Sons |
Pages | 421 |
Release | 2012-02-10 |
Genre | Medical |
ISBN | 1118146999 |
This is a comprehensive source of information on the application of ion chromatography (IC) in the analysis of pharmaceutical drugs and biologicals. This book, with contributors from academia, pharma, the biotech industry, and instrument manufacturing, presents the different perspectives, experience, and expertise of the thought leaders of IC in a comprehensive manner. It explores potential IC applications in different aspects of product development and quality control testing. In addition, an appendix section gives information on critical physical and chromatographic parameters related to IC and information on current manufacturers of IC systems, columns, and other components.