The formulation, analysis, and re-evaluation of mathematical models in population biology has become a valuable source of insight to mathematicians and biologists alike. This book presents an overview and selected sample of these results and ideas, organized by biological theme rather than mathematical concept, with an emphasis on helping the reader develop appropriate modeling skills through use of well-chosen and varied examples. Part I starts with unstructured single species population models, particularly in the framework of continuous time models, then adding the most rudimentary stage structure with variable stage duration. The theme of stage structure in an age-dependent context is developed in Part II, covering demographic concepts, such as life expectation and variance of life length, and their dynamic consequences. In Part III, the author considers the dynamic interplay of host and parasite populations, i.e., the epidemics and endemics of infectious diseases. The theme of stage structure continues here in the analysis of different stages of infection and of age-structure that is instrumental in optimizing vaccination strategies. Each section concludes with exercises, some with solutions, and suggestions for further study. The level of mathematics is relatively modest; a "toolbox" provides a summary of required results in differential equations, integration, and integral equations. In addition, a selection of Maple worksheets is provided. The book provides an authoritative tour through a dazzling ensemble of topics and is both an ideal introduction to the subject and reference for researchers.

Although its roots can be traced to the 19th century, progress in the study of nonlinear dynamical systems has taken off in the last 30 years. While pertinent source material exists, it is strewn about the literature in mathematics, physics, biology, economics, and psychology at varying levels of accessibility. A compendium research methods reflect

Model Validation and Uncertainty Quantification, Volume 3. Proceedings of the 33rd IMAC, A Conference and Exposition on Balancing Simulation and Testing, 2015, the third volume of ten from the Conference brings together contributions to this important area of research and engineering. The collection presents early findings and case studies on fundamental and applied aspects of Structural Dynamics, including papers on: Uncertainty Quantification & Model Validation Uncertainty Propagation in Structural Dynamics Bayesian & Markov Chain Monte Carlo Methods Practical Applications of MVUQ Advances in MVUQ & Model Updating

State Estimation for Dynamic Systems presents the state of the art in this field and discusses a new method of state estimation. The method makes it possible to obtain optimal two-sided ellipsoidal bounds for reachable sets of linear and nonlinear control systems with discrete and continuous time. The practical stability of dynamic systems subjected to disturbances can be analyzed, and two-sided estimates in optimal control and differential games can be obtained. The method described in the book also permits guaranteed state estimation (filtering) for dynamic systems in the presence of external disturbances and observation errors. Numerical algorithms for state estimation and optimal control, as well as a number of applications and examples, are presented. The book will be an excellent reference for researchers and engineers working in applied mathematics, control theory, and system analysis. It will also appeal to pure and applied mathematicians, control engineers, and computer programmers.

The Likelihood plays a key role in both introducing general notions of statistical theory, and in developing specific methods. This book introduces likelihood-based statistical theory and related methods from a classical viewpoint, and demonstrates how the main body of currently used statistical techniques can be generated from a few key concepts, in particular the likelihood. Focusing on those methods, which have both a solid theoretical background and practical relevance, the author gives formal justification of the methods used and provides numerical examples with real data.

Systems Biology is now entering a mature phase in which the key issues are characterising uncertainty and stochastic effects in mathematical models of biological systems. The area is moving towards a full statistical analysis and probabilistic reasoning over the inferences that can be made from mathematical models. This handbook presents a comprehensive guide to the discipline for practitioners and educators, in providing a full and detailed treatment of these important and emerging subjects. Leading experts in systems biology and statistics have come together to provide insight in to the major ideas in the field, and in particular methods of specifying and fitting models, and estimating the unknown parameters. This book: Provides a comprehensive account of inference techniques in systems biology. Introduces classical and Bayesian statistical methods for complex systems. Explores networks and graphical modeling as well as a wide range of statistical models for dynamical systems. Discusses various applications for statistical systems biology, such as gene regulation and signal transduction. Features statistical data analysis on numerous technologies, including metabolic and transcriptomic technologies. Presents an in-depth presentation of reverse engineering approaches. Provides colour illustrations to explain key concepts. This handbook will be a key resource for researchers practising systems biology, and those requiring a comprehensive overview of this important field.