The idea of editing this book was born in the winter of 1988/1989. Christian Endler was organizing the workshop 'Wasser und Information' (water and information) in Austria [1], and Jürgen Schulte was working on a publication of his results on atomic cluster stabilities and long-range electromagnetic interaction in atomic clusters. It was Franz Moser from the Technical University of Graz who brought these two together. After a talk that Moser had given in Bremen, Schulte explained to hirn his ideas about clusters and long range interaction, and his concern about reliable theories and experiments in research on ultra high dilutions (UHD) and homoeopathy. He was suggested to be a speaker at the Austrian workshop. Reviewing the contributions of this workshop and the current literature on UHD and homoeopathy, especially the PhD thesis by Giesela King [2] and the excellent survey by Marco Righetti [3], we decided to work on a book in order to critically encou rage more scientists to work and publish in this field with a high scientific standard. What we had in mind was a useful contribution to the goal to lift research on UHD and homoeo pathy to an internationally acceptable scientific standard, to encourage international scien tists to work in this area and to establish UHD and homoeopathy in academic science. Delayed by our individual academic careers in our specific fields, and delayed by lack of funds it took us about four years to finish this book.

Jurgen Schulte and Christian Endler met in 1990 at an international conference on the Structure of Water held in the Lecture Halls of the University of Graz (Austria). Disappointed by the lack of a systematic strategy of research into the physics of homoeopathy Jurgen Schulte started to work on the establishment of scientifically acceptable research standards in physics of homoeopathy and encouraged academic researchers to establish a coordinated and focused research strategy. In 1994, with the help of major representatives of the international research community, they edited one of the fIrst academic interdisciplinary books on Ultra High Dilution and homoeopathy that underwent a rigorous scientific international referee process before publishing. Due to the dedicated help of the prominent referees (BD Josephson, Nobel Laureate, Cavendish Lab. , Cambridge; M Bastide, Fac de Pharmacy, University Montpellier; RG Jahn, Aerospace Science, Princeton University), the book 1994 was quickly considered a mile stone and turning point for the scientific approach of research into Ultra High Dilution and homoeopathy. Since then the academic research community has grown considerably and many international conferences have been held. Today, research into homoeopathy is to be accepted by the European Union as part of the academic sciences, worthy to be funded at European Union level; an effort that took many years of research coordination and research strategy development. Excerpts of the Research Strategy of the European Committee for Homoeopathy (ECH) have been included in this book.

High dilution effects constitute a major problem on the frontier of biophysics. The reported effects on simple and complex biological systems range from in vitro and in vivo models to cellular metabolism regulation, the immune system, the nervous system, intoxicated organs and organisms, and developmental models. The physical properties of high dilutions have been considered, such as the organization properties of water molecules in the presence and after the presence of solute molecules, the energy characteristics of empty and full water clusters, and their dynamical interactions with proteins. Among the mechanisms responsible for the high dilution effects, a non-molecular transfer of information has been hypothesized.

High dilution effects constitute a major problem on the frontier of biophysics. The reported effects on simple and complex biological systems range from in vitro and in vivo models to cellular metabolism regulation, the immune system, the nervous system, intoxicated organs and organisms, and developmental models. The physical properties of high dilutions have been considered, such as the organization properties of water molecules in the presence and after the presence of solute molecules, the energy characteristics of empty and full water clusters, and their dynamical interactions with proteins. Among the mechanisms responsible for the high dilution effects, a non-molecular transfer of information has been hypothesized.

In this updated reissue of their classic Homeopathy: A Frontier in Medical Science, Italian physicians Paolo Bellavite and Andrea Signorini thoroughly examine previous and current literature on the science of homeopathy in order to discover answers to the elemental questions about homeopathy. Bellavite and Signorini engage in a fascinating discussion of the biophysics of water, biological effects of electomagnetic fields, chaos theory, and fractals.

While evidence for the biological effects of high dilutions (above Avogadro’s number) has been extensively documented since the 1980s, it seems to remain invisible to part of the global scientific community. This book provides investigators and other interested readers with direct access to the latest research, conducted between 2009 and 2019, by members of the Groupe International de Recherche sur l’Infinitésimal, the first international scientific society devoted to scientific studies of high dilutions. As shown here, the state of the art in high dilution research allows answering with a sound, evidence-based “no” to the question “Is homeopathy really that implausible?” Therefore this book is an essential contribution to the ongoing debate on complementary and alternative medicine, much-needed by practitioners, patients, and governments in the formulation of healthcare policies.