This new anthology has original, never-before-told stories featuring one of the world's most enduring heroes, beginning with an unforgettable novella cowritten by Spider-Man's creator himself. Other authors include David Michelinie, Craig Shaw Gardner, Peter David, and many more.

Collects Ultimate Spider-Man #118-123. "Spider-Man and his Amazing Friends!" Things are changing in the young life of Peter Parker: Johnny Storm of the Fantastic Four is now his buddy - and the hot-headed super hero has taken a liking to Peter's classmate, Liz Allen! But something is horribly wrong with Liz - something that will soon affect the life of every student at Midtown High - including Peter's ex-girlfriend, Kitty Pryde!

When the Peter Parker of the Ultimate Universe falls, the world needs a Spider-Man - and here comes Miles Morales! But what's the secret behind his powers - and can he master them before the Scorpion strikes? Family life gets complicated as Miles learns the truth about his uncle Aaron, and Captain America comes calling when war breaks out! Miles shares a multiversal meeting of the Spider-Men with the Marvel Universe's Peter Parker - but what tragedy could leave the young hero swearing never to wear the webs again? There'll be familiar faces, heroic allies, deadly menaces, a startling return - and a sprinkling of romance - in the complete Ultimate Universe adventures of Miles Morales! COLLECTING: ULTIMATE COMICS SPIDER-MAN 1-28, 16.1; SPIDER-MEN 1-5; CATACLYSM: ULTIMATE SPIDER-MAN 1-3; ULTIMATE SPIDER-MAN 200; MILES MORALES: ULTIMATE SPIDER-MAN 1-12; MATERIAL FROM ULTIMATE FALLOUT 4

"Six month ago, Crossbones kidnapped the Red Skull's daughter, Sin, from a government re-education facility and disappeared into the night. Now, he and this spawn of infinite evil have come to the American Midwest to tear a new hole in A.I.M. - but none of them counted on S.H.I.E.L.D. Agent 13 stumbling into the mix, and everything going wrong!" -Back cover, volume 1.

A group of genetically altered men--Norman Osborn, Dr. Otto Octavius, Flint Marko, Max Dillon, and Sergei Kravinoff--escape from the S.H.I.E.L.D. containment center and band together to try and defeat Spider-Man.

Collects Ultimate Spider-Man (2000) #14-27. The Green Goblin returns - will Spider-Man survive the rematch? Peter Parker has a secret. Bitten by a radioactive spider, he gained the powers of a human arachnid - super-strength, adhesion to walls and incredible agility. Inspired by his uncle's tragic death, Peter became Spider-Man, New York City's hometown super hero. Only two people know his secret identity - one is his best friend, confidante and girlfriend Mary Jane Watson. The other - ruthless businessman Norman Osborn, otherwise known as the Green Goblin. In their first battle, Norman nearly killed Peter before his own apparent death. But now, the Goblin has returned, more powerful than ever before. And Osborn will use his knowledge of Peter's double identity to control the teenager - threatening the lives of Mary Jane and his beloved Aunt May if Peter refuses to obey. Will Spider-Man be forced to serve his greatest enemy to protect his loved ones from harm?

Collects Ultimate Spider-Man (2000) #1/2 & #28-39. Collecting the groundbreaking third year of ULTIMATE SPIDER-MAN in one colossal collection! Spider-Man beat Kraven. He defeated Dr. Octopus. He even survived a serious scrap with an artificially enhanced Green Goblin. As it turns out, though, his worst enemy is a simple crook in a Spider-Man suit. That's all it takes to ruin Spider-Man's reputation, suddenly painting Peter Parker's alter ego as Public Enemy No. 1...and changing his life forever. Then: Spider-Man's ultimate villain gets the Ultimate treatment! After reuniting with his childhood friend Eddie Brock, Peter discovers a secret about their fathers' pasts...a black liquid that can transform into a protoplasmic bodysuit, curing any illness and enhancing the wearer's strength and abilities. But when Peter tries to continue his father's work, he accidentally becomes encased in the murky liquid and becomes nearly unstoppable...but at a terrible price.