The pathologist who sees specimens from lesions of the serosal membranes (pleura, pericardium, peritoneum, and tunica vaginalis) is well aware that these cases, whether in the form of fluid cytologies, small biopsies, or major resections, pose differential diagnostic problems that are among the most difficult in anatomic pathology. The main problems involve the separation of malignant mesothelioma from benign mesothelial processes on the one hand and other malignant tumours (particularly primary and metastatic carcinomas) on the other. With these differential diagnoses in mind, the authors concentrate on the cytopathologic and histopathologic features of diffuse malignant mesothelioma, its many variants, and the other benign and malignant lesions to be distinguished from it. Histochemical, immunohistochemical, ultrastructural and molecular features of potential use in this differentiation are discussed and illustrated. Common differential diagnostic problems and their solutions take precedence, but all of the known benign and malignant lesions of serosal membranes are covered, with copious illustrations and the latest available references. Epidemiologic, pathogenetic, clinical, radiographic and gross pathologic features are integrated with the discussions of these entities. This will be the most complete source available on this topic for years to come.

Since the publication of the first edition of this best-selling book in 2009, the field of immunohistochemistry has advanced significantly. Fully updated to reflect the latest developments in the field, Modern Immunohistochemistry, Second Edition, is a practical guide to all the important diagnostic markers in each organ system. Concise text is supplemented by over 1,100 high-quality colour images and algorithms. The new edition features even more summary tables, highlighting the key points of differential immunophenotypic panels. A new, expanded introduction explains the basic principles of immunohistochemistry, and chapters have been updated to incorporate predictive/prognostic markers and the latest WHO classifications. All chapters are written by the same expert authors, providing a consistent, engaging style throughout and avoiding contradictory advice. An essential text for residents, this is also an extremely valuable resource for practitioners in anatomic pathology wishing to familiarise themselves with diagnostic markers at a quick glance.