The ATSDR toxicological profile succinctly characterizes the toxicology and adverse health effects information for the toxic substance described therein. Each peer-reviewed profile identifies and reviews the key literature that describes a substance's toxicological properties. ATSDR's Toxicological Profile for 1,2-Dibromo-3-chloropropane was released in 1992. In order to update the literature in this profile, ATSDR conducted a literature search focused on health effects information as described in Appendix B. Chapters 2, 3, and 7 were revised to reflect the most current health effects data. In some cases, other sections of the profile were updated as needed or for consistency with the updated health effects and regulations/guidelines. However, the focus of the update to this profile is on health effects information. The major sources of 1,2-dibromo-3-chloropropane (C3H5Br2Cl; CAS Number 96-12-8) in the environment are from its former use as a soil fumigant (fumes that rid vermin or disinfect) and nematocide (worm killer) on a variety of crops and from unintentional release from hazardous waste sites that contain the chemical. There have been no recent reportable releases of 1,2-dibromo-3-chloropropane to the air, water, or soil (TRI16 2017) because all registered uses as a pesticide were canceled by the U.S. Environmental Protection Agency (EPA) in 1985. The most likely sources of exposure of the general population to 1,2-dibromo-3-chloropropane are from drinking water that may have been contaminated in areas where the chemical was used for agricultural purposes or from food sources grown in soil that may still contain residues. However, it is not likely that the general population would be exposed to 1,2-dibromo-3-chloropropane levels in drinking water or food sources that would be high enough to cause adverse health effects.