Motivated by the explosion of molecular data on humans-particularly data associated with individual patients-and the sense that there are large, as-yet-untapped opportunities to use this data to improve health outcomes, Toward Precision Medicine explores the feasibility and need for "a new taxonomy of human disease based on molecular biology" and develops a potential framework for creating one. The book says that a new data network that integrates emerging research on the molecular makeup of diseases with clinical data on individual patients could drive the development of a more accurate classification of diseases and ultimately enhance diagnosis and treatment. The "new taxonomy" that emerges would define diseases by their underlying molecular causes and other factors in addition to their traditional physical signs and symptoms. The book adds that the new data network could also improve biomedical research by enabling scientists to access patients' information during treatment while still protecting their rights. This would allow the marriage of molecular research and clinical data at the point of care, as opposed to research information continuing to reside primarily in academia. Toward Precision Medicine notes that moving toward individualized medicine requires that researchers and health care providers have access to very large sets of health- and disease-related data linked to individual patients. These data are also critical for developing the information commons, the knowledge network of disease, and ultimately the new taxonomy.

The potential impact of the information superhighwayâ€"what it will mean to daily work, shopping, and entertainmentâ€"is of concern to nearly everyone. In the rush to put the world on-line, special issues have emerged for researchers, educators and students, and library specialists. At the same time, the research and education communities have a valuable head start when it comes to understanding computer communications networks, particularly Internet. With its roots in the research community, the Internet computer network now links tens of millions of people and extends well into the commercial world. Realizing the Information Future is written by key players in the development of Internet and other data networks. The volume highlights what we can learn from Internet and how the research, education, and library communities can take full advantage of the information highway's promised reach through time and space. This book presents a vision for the proposed national information infrastructure (NII): an open data network sending information services of all kinds, from suppliers of all kinds, to customers of all kinds, across network providers of all kinds. Realizing the Information Future examines deployment issues for the NII in light of the proposed system architecture, with specific discussion of the needs of the research and education communities. What is the role of the "institution" when everyone is online in their homes and offices? What are the consequences when citizens can easily access legal, medical, educational, and government services information from a single system? These and many other important questions are explored. The committee also looks at the development of principles to address the potential for abuse and misuse of the information highway, covering: Equitable and affordable access to the network. Reasonable approaches to controlling the rising tide of electronic information. Rights and responsibilities relating to freedom of expression, intellectual property, individual privacy, and data security. Realizing the Information Future includes a wide-ranging discussion of costs, pricing, and federal funding for network development and a discussion of the federal role in making the best technical choices to ensure that the expected social and economic benefits of the NII are realized. The time for the research and education communities to have their say about the information highway is before the ribbon is cut. Realizing the Information Future provides a timely, readable, and comprehensive exploration of key issuesâ€"important to computer scientists and engineers, researchers, librarians and their administrators, educators, and individuals interested in the shape of the information network that will soon link us all.

The Science Subcommittee began its oversight of the implementation of the High-Performance Computing Act of 1991 by focusing on the establishment of the National Research and Education Network (NREN), which will evolve out of the current internet, the National Science Foundation's (NSF) NSFNET. The policy issues under discussion were: providing a level playing field for network services providers; ensuring that the network is responsive to user needs; providing for effective network management; determining the level of consultation that has occurred between the NSF, the network user, and provider communities during the course of developing the policies for governance and operation of the NSFNET backbone; and moving toward the long-term vision for the NREN, including the appropriate roles of the public and private sectors. Included in the hearing report are statements from Bob Traxler and Jerry F. Costello of the House Subcommittee on Science and testimony from the following witnesses: Eric Hood, Federation of American Research Networks and Northwestnet, Inc.; Douglas E. Van Houweling, Merit Network, Inc. and the University of Michigan, Ann Arbor; Mitchell Kapor, Commercial Internet Exchange Association and Electronic Frontier Foundation; Michael M. Roberts, Educom; William L. Schrader, Performance Systems International, Inc. Also included are a statement by A. Nico Habermann and Stephen S. Wolff, National Science Foundation; the Subcommittee and Full Committee markups of H.R. 5344, Amendment to the NSF Act of 1950; and an additional statement submitted for the record by E. Michael Staman, CICNet. (ALF)