This Otolaryngologic Clinics' publication's intent is to provide standard and state of the art clinician performed thyroid ultrasound and ultrasound guided FNA technique. The subject area is evolving rapidly with new technologies being incorporated. This title integrates thyroid cytology, FNA and Ultrasound Guided FNA with inclusion of diagnostic molecular testing. Clinical Thyroid Molecular Testing has ushered in a new era to the diagnosis, management and prognostication of thyroid nodules. The discussion of this highly clinically applicable subject is described in terms of diagnostic process. This is a thyroid neoplasm clinical "game changer” for the General Otolaryngologist, Head and Neck Surgeon, General Surgeon, Endocrinologist, Pathologist, and Radiologist. This testing maximizes the number of patients who have cancer to receive the correct therapeutic surgery appropriately and minimizes the number of patients who do not need surgery (and avoid the potential complications and surgery) because they do not have cancer. Surgical management and prognostication have far reaching implications with fine needle aspiration driven molecular markers. Some topics include: Clinical evaluation of the thyroid nodule; Thyroid cytology; Clinician performed thyroid ultrasound; Clinician performed thyroid ultrasound guided FNA; Thyroid cancer molecular laterations - what the surgeon should know; Thyroid cancer multi-gene expression - what the surgeon needs to know; Incorporating molecular testing into your thyroid practice - five experts discuss; and others.

This issue of Endocrinology and Metabolism Clinics, guest edited by Dr. Michael Mingzhao Xing, is dedicated to Thyroid Cancer. Topics include, but are not limited to, Current Histological Classification of Thyroid Cancer, Molecular Pathogenesis and Mechanisms of Thyroid Cancer, Clinical Diagnostic Evaluation of Thyroid Nodules, Molecular Diagnostic Evaluation of Thyroid Nodules, Clinical Risk Stratification of Differentiated Thyroid Cancer, Molecular Risk Stratification of Differentiated Thyroid Cancer, Conventional Thyroidectomy in the Treatment of Primary Thyroid Cancer, Neck Dissection in the Surgical Treatment of Thyroid Cancer, Conventional Robotic Endoscopic Thyroidectomy for Thyroid Cancer, Transoral Endoscopic Thyroidectomy for Thyroid Cancer, Conventional Radioiodine Therapy for Differentiated Thyroid Cancer, Re-differentiation of Radioiodine-refractory Thyroid Cancer for Radioiodine Treatment, Management of Papillary Thyroid Microcarcinoma, Conservative Surveillance Management of Low-risk Papillary Thyroid Microcarcinoma, Thyroid-stimulating Hormone Suppression Therapy in Differentiated Thyroid Cancer, Diagnostic Imaging Testing in the Surveillance of Thyroid Cancer Recurrence, Novel Drug Treatments of Progressive Radioiodine-refractory Differentiated Thyroid Cancer, Management of Anaplastic Thyroid Cancer, and Management of Medullary Thyroid cancer.

Guest Editors Colin L. Driscoll and Brian A. Neff have brought together leading experts to review the current state of active middle ear implants. This issue of Otolaryngologic Clinics will explore the history of device development to aid in understanding what has led to successful platforms. Articles in this issue include: Sound Transfer of Active Middle Ear Implants; Historical Development of Active Middle Ear Implants; Vibrant Soundbridge Rehabilitation of Conductive and Mixed Hearing Loss; Vibrant Soundbridge Rehabilitation of Sensorineural Hearing Loss; The Envoy Esteem Implantable Hearing System; Implantable Hearing Devices: The Ototronix MAXUM System; and Otologics Active Middle Ear Implants.

National health statistics indicate that pediatric ear, nose, and throat disorders remain among the primary reasons children visit a physician, with ear infections ranking as the number one reason. From earaches to choking hazards, from nosebleeds to speech irregularities, children can present with a variety of problems that cause concern to parents and caregivers, who want prompt diagnosis and treatment. The presentation of topics in this issue is clinically ppropriate for Otolaryngologists, Pediatricians, Allergy specialists, and Family Physicians. Topics in this issue of Otolaryngologic Clinics include: Hearing screening and hearing loss; Acute otitis media; Chronic adenotonsilitis; Pediatric dysphagia; Lymphadenopathy; Rhinosinusitis; Facial trauma; Sialadenitis; Behavior and otolaryngology; Stridor; Otolaryngologic management of severe neurodevelopmental delay; Pediatric craniofacial problems.

Experts from childrens' hospitals across the United States discuss diagnosis, treatment, and pathophysiology of head and neck masses in children. Topics include: Branchial cleft cysts; Thyroglossal duct cyst and ectopic thyroid; Vascular malformations; Thyroid nodule and malignancy in children; Lymphoma in pediatrics; Malignancies in the pediatric head and neck - rhabdomyosarcoma and neuroblastoma; Skull base and more including intranasal masses; Tumors of the maxsilla and mandible; Teratoma and dermoid cysts; Inflammatory adenopathy; Disorders and tumors of the salivary glands; Intraoral and lingual lesions; and the Exit procedure. Beyond relevance to Otolaryngologists, this issue of Otolaryngologic Clinics is appropriate for cancer specialists, pediatricians, family practitioners, general surgeons, and pediatric nurse practitioners. Residents training in those fields, as well as Neurosurgery and Ophthalmology, will find this practical.

Early identification and diagnosis by type and stage is the key to high survival rates with thyroid cancer. To present the pathologist with current clinical information on diagnosis, differential diagnosis, staging, and prognosis of thyroid cancers, topics presented are: Poorly differentiated thyroid carcinoma; Paraganglimoa; Immunohistochemical markers for evaluation and prognosis in thyroid carcinoma; Familial endocrine syndromes; Parathyroid enoplasia; Inflammatory lesions of the thyroid associated with cancer; Assessing biological aggression in adrenal cortical neoplasia; Pituitary neoplasia; and Pancreatic endocrine neoplasia. Peter Sadow, whose clinical practice and research involve studying the mechanisms of endocrine carcinogenesis through translational studies involving the proteomics and genomics of endocrine neoplasms, primarily of the thyroid and adrenal glands, leads this issue.

The Editors for this issue of Otolaryngologic Clinics, Dr George Wanna and Dr Matthew Luke Carlson, envisioned a publication that reviews the evaluation and management of common ear and lateral skull base tumors. Intended audience includes Otologists, Neurotologists, General otolaryngologists and Neurosurgeons alike. The development of management of lateral skull base tumors has been rapid, in the past 40 years there has been a tremendous shift toward conservative therapy for benign lesions. Focused chapters review specific pathologies plus a chapter focused on stereotactic radiotherapy. Topics written by reputed leaders in the field of Otology and skull base tumors include: Imaging of temporal bone lesions; Squamous cell carcinoma of the temporal bone; Glomus tympanicum; Adenomatous tumors of the middle ear; Intralabyrinthine schwannomas; Vestibular schwannoma; Neurofibromatosis2 (including ABI and CI); Non-schwannoma tumors of the CPA; Glomus jugulare; Endolymphatic sac tumors; Non-paraganglioma jugular foramen tumors; Primary tumors of the facial nerve; Cholesterol granuloma and other petrous apex lesions; Stereotactic radiosurgery for tumors of the lateral skull base; Pediatric temporal bone malignancy; and Historical perspective on evolution in management of lateral skull base tumors.