Therapeutic Monoclonal Antibodies and Antibody Products, Their Optimization and Drug Design in Cancers
Title | Therapeutic Monoclonal Antibodies and Antibody Products, Their Optimization and Drug Design in Cancers PDF eBook |
Author | Veysel Kayser |
Publisher | Mdpi AG |
Pages | 298 |
Release | 2022-01-25 |
Genre | |
ISBN | 9783036526874 |
The book broadly deals with therapeutic monoclonal antibodies (mAbs) and various relevant topics, including different antibody formats such as Antibody-Drug Conjugates (ADC), bispecifics, nanoparticle-based mAbs and HER2+ cancers, immune checkpoint inhibitors and other closely related topics. Each paper was written by leading active research groups in their fields both from academia and industry. The book should be of interest to those scientists and researchers who develop or use biologics, biotherapeutics, biosimilars and biobetters in cancer treatment.
Innovations for Next-Generation Antibody-Drug Conjugates
Title | Innovations for Next-Generation Antibody-Drug Conjugates PDF eBook |
Author | Marc Damelin |
Publisher | Springer |
Pages | 358 |
Release | 2018-05-29 |
Genre | Medical |
ISBN | 3319781545 |
Antibody-drug conjugates (ADCs) stand at the verge of a transformation. Scores of clinical programs have yielded only a few regulatory approvals, but a wave of technological innovation now empowers us to overcome past technical challenges. This volume focuses on the next generation of ADCs and the innovations that will enable them. The book inspires the future by integrating the field’s history with novel strategies and cutting-edge technologies. While the book primarily addresses ADCs for solid tumors, the last chapter explores the emerging interest in using ADCs to treat other diseases. The therapeutic rationale of ADCs is strong: to direct small molecules to the desired site of action (and away from normal tissues) by conjugation to antibodies or other targeting moieties. However, the combination of small and large molecules imposes deep complexity to lead optimization, pharmacokinetics, toxicology, analytics and manufacturing. The field has made significant advances in all of these areas by improving target selection, ADC design, manufacturing methods and clinical strategies. These innovations will inspire and educate scientists who are designing next-generation ADCs with the potential to transform the lives of patients.
Monoclonal Antibody-Directed Therapy
Title | Monoclonal Antibody-Directed Therapy PDF eBook |
Author | Veysel Kayser |
Publisher | Mdpi AG |
Pages | 144 |
Release | 2022-01-28 |
Genre | Science |
ISBN | 9783036528731 |
The book deals with therapeutic monoclonal antibodies (mAbs) broadly, and relevant topics such as challenges and opportunities, next-generation antibody products, Antibody-Drug-Conjugates (ADC), bispecifics, glycosylation, and T-cell engagers are covered. Each topic has been written by leading groups around the world and the book should be of interest to researchers from both academia and industry.
Monoclonal Antibody Production
Title | Monoclonal Antibody Production PDF eBook |
Author | National Research Council |
Publisher | National Academies Press |
Pages | 74 |
Release | 1999-05-06 |
Genre | Medical |
ISBN | 0309173051 |
The American Anti-Vivisection Society (AAVS) petitioned the National Institutes of Health (NIH) on April 23, 1997, to prohibit the use of animals in the production of mAb. On September 18, 1997, NIH declined to prohibit the use of mice in mAb production, stating that "the ascites method of mAb production is scientifically appropriate for some research projects and cannot be replaced." On March 26, 1998, AAVS submitted a second petition, stating that "NIH failed to provide valid scientific reasons for not supporting a proposed ban." The office of the NIH director asked the National Research Council to conduct a study of methods of producing mAb. In response to that request, the Research Council appointed the Committee on Methods of Producing Monoclonal Antibodies, to act on behalf of the Institute for Laboratory Animal Research of the Commission on Life Sciences, to conduct the study. The 11 expert members of the committee had extensive experience in biomedical research, laboratory animal medicine, animal welfare, pain research, and patient advocacy (Appendix B). The committee was asked to determine whether there was a scientific necessity for the mouse ascites method; if so, whether the method caused pain or distress; and, if so, what could be done to minimize the pain or distress. The committee was also asked to comment on available in vitro methods; to suggest what acceptable scientific rationale, if any, there was for using the mouse ascites method; and to identify regulatory requirements for the continued use of the mouse ascites method. The committee held an open data-gathering meeting during which its members summarized data bearing on those questions. A 1-day workshop (Appendix A) was attended by 34 participants, 14 of whom made formal presentations. A second meeting was held to finalize the report. The present report was written on the basis of information in the literature and information presented at the meeting and the workshop.
Antibody-Drug Conjugates and Immunotoxins
Title | Antibody-Drug Conjugates and Immunotoxins PDF eBook |
Author | Gail Lewis Phillips |
Publisher | Springer Science & Business Media |
Pages | 370 |
Release | 2012-12-13 |
Genre | Medical |
ISBN | 1461454565 |
This volume gathers the leading research on antibody-drug conjugates and immunotoxins. Following a rigorous overview, the volume delves into focused sections on all aspects of ADCs and ITs from clinical development through to targeted therapeutic applications and the latest technologies.
Antibody-Drug Conjugates
Title | Antibody-Drug Conjugates PDF eBook |
Author | Kenneth J. Olivier, Jr. |
Publisher | John Wiley & Sons |
Pages | 567 |
Release | 2016-11-14 |
Genre | Medical |
ISBN | 1119060842 |
Providing practical and proven solutions for antibody-drug conjugate (ADC) drug discovery success in oncology, this book helps readers improve the drug safety and therapeutic efficacy of ADCs to kill targeted tumor cells. • Discusses the basics, drug delivery strategies, pharmacology and toxicology, and regulatory approval strategies • Covers the conduct and design of oncology clinical trials and the use of ADCs for tumor imaging • Includes case studies of ADCs in oncology drug development • Features contributions from highly-regarded experts on the frontlines of ADC research and development
Therapeutic Monoclonal Antibodies
Title | Therapeutic Monoclonal Antibodies PDF eBook |
Author | Zhiqiang An |
Publisher | John Wiley & Sons |
Pages | 932 |
Release | 2011-09-20 |
Genre | Science |
ISBN | 1118210263 |
70-chapter authoritative reference that covers therapeutic monoclonal antibody discovery, development, and clinical applications while incorporating principles, experimental data, and methodologies. First book to address the discovery and development of antibody therapeutics in their entirety. Most chapters contain experimental data to illustrate the principles described in them. Authors provide detailed methodologies that readers can take away with them and use in their own laboratories.