The Wnt/b-catenin Signalling Pathway and Anterior Posterior Patterning in the Vertebrate Central Nervous System
Title | The Wnt/b-catenin Signalling Pathway and Anterior Posterior Patterning in the Vertebrate Central Nervous System PDF eBook |
Author | Pedro Manuel Dias Neto Domingos |
Publisher | |
Pages | |
Release | 2001 |
Genre | |
ISBN |
The Wnt/β-catenin Signalling Pathway and Anterior/posterior Patterning in the Vertebrate Central Nervous System
Title | The Wnt/β-catenin Signalling Pathway and Anterior/posterior Patterning in the Vertebrate Central Nervous System PDF eBook |
Author | Pedro Manuel Dias Neto Domingos |
Publisher | |
Pages | |
Release | 2001 |
Genre | |
ISBN |
Wnt/[beta]-catenin Signaling in Vertebrate Posterior Neural Development
Title | Wnt/[beta]-catenin Signaling in Vertebrate Posterior Neural Development PDF eBook |
Author | Yaniv Elkouby |
Publisher | Morgan & Claypool Publishers |
Pages | 89 |
Release | 2010 |
Genre | Medical |
ISBN | 1615040544 |
The Wnt/β-catenin signaling pathway is a key regulator of cell fate specification, differentiation, and growth in multiple systems throughout the animal kingdom. In vertebrate posterior neural development, Wnt/β-catenin signaling controls this complex multistep process. It initially induces the posterior regions of the nervous system, including the mid-hindbrain border, hindbrain, spinal cord and neural crest, and then subsequently fine-tunes the pattern of each region and determines the different cell fates within them. In this review, we explore the function of the Wnt/β-catenin pathway during the formation of these specific posterior neural regions. We have examined the important transcriptional targets of the Wnt/β-catenin pathway acting downstream to mediate its morphogenetic activity. Different regulatory networks are activated in different posterior neural regions, and these networks induce specific neural cell types in each region. Eludidating how each of these networks specify different cell fates is crucial for understanding the basic tenets of how Wnt morphogenetic activity induces the posterior nervous system during the earliest stages of vertebrate development. Table of Contents: Introduction / Making the Neural Rear / Wnt Morphogenetic Activity in Neural Posterior Induction / Induction of the Midbrain-Hindbrain Border / Induction of the Hindbrain / Induction of the Spinal Cord / Downstream of Wnt: Hindbrain or Spinal Cord? / Neural Crest Induction / Anti-Wnt Anterior Determinants / The Role of Mesoderm and Specific Wnt Ligands in Neural Patterning / Concluding Remarks / References
The Wnt/catenin Signalling Pathway and Anterior/posterior/patterning in the Vertebrate Central Nervous System
Title | The Wnt/catenin Signalling Pathway and Anterior/posterior/patterning in the Vertebrate Central Nervous System PDF eBook |
Author | |
Publisher | |
Pages | 302 |
Release | 2001 |
Genre | |
ISBN |
Planarian Regeneration
Title | Planarian Regeneration PDF eBook |
Author | Jochen C. Rink |
Publisher | Humana |
Pages | 0 |
Release | 2018-06-19 |
Genre | Science |
ISBN | 9781493978007 |
This volume explores the various facets of planaria as a biomedical model system and discusses techniques used to study the fascinating biology of these animals. The chapters in this book are divided into two parts: Part One looks at the biodiversity of planarian species, the molecular orchestration of regeneration, ecology of planarians in their natural habitats and their history as lab models. Part Two talks about experimental protocols for studying planarians, ranging from the establishment of a planarian research colony, to RNA and DNA extraction techniques, all the way to single stem cell transplantations or metabolomics analysis. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Comprehensive and cutting-edge, Planarian Regeneration: Methods and Protocols is a valuable resource for both newcomers to the field and experts within established planarian laboratories.
Vascular Development
Title | Vascular Development PDF eBook |
Author | Derek J. Chadwick |
Publisher | John Wiley & Sons |
Pages | 260 |
Release | 2007-08-20 |
Genre | Science |
ISBN | 0470319429 |
The formation of blood vessels is an essential aspect of embryogenesis in vertebrates. It is a central feature of numerous post-embryonic processes, including tissue and organ growth and regeneration. It is also part of the pathology of tumour formation and certain inflammatory conditions. In recent years, comprehension of the molecular genetics of blood vessel formation has progressed enormously and studies in vertebrate model systems, especially the mouse and the zebrafish, have identified a common set of molecules and processes that are conserved throughout vertebrate embryogenesis while, in addition, highlighting aspects that may differ between different animal groups. The discovery in the past decade of the crucial role of new blood vessel formation for the development of cancers has generated great interest in angiogenesis (the formation of new blood vessels from pre-existing ones), with its major implications for potential cancer-control strategies. In addition, there are numerous situations where therapeutic treatments either require or would be assisted by vasculogenesis (the de novo formation of blood vessels). In particular, post-stroke therapies could include treatments that stimulate neovascularization of the affected tissues. The development of such treatments, however, requires thoroughly understanding the developmental properties of endothelial cells and the basic biology of blood vessel formation. While there are many books on angiogenesis, this unique book focuses on exactly this basic biology and explores blood vessel formation in connection with tissue development in a range of animal models. It includes detailed discussions of relevant cell biology, genetics and embryogenesis of blood vessel formation and presents insights into the cross-talk between developing blood vessels and other tissues. With contributions from vascular biologists, cell biologists and developmental biologists, a comprehensive and highly interdisciplinary volume is the outcome.
Wnt/?-Catenin Signaling in Vertebrate Posterior Neural Development
Title | Wnt/?-Catenin Signaling in Vertebrate Posterior Neural Development PDF eBook |
Author | Yaniv M. Elkouby |
Publisher | Biota Publishing |
Pages | 90 |
Release | 2010-08-01 |
Genre | Science |
ISBN | 1615040552 |
The Wnt/β-catenin signaling pathway is a key regulator of cell fate specification, differentiation, and growth in multiple systems throughout the animal kingdom. In vertebrate posterior neural development, Wnt/β-catenin signaling controls this complex multistep process. It initially induces the posterior regions of the nervous system, including the mid-hindbrain border, hindbrain, spinal cord and neural crest, and then subsequently fine-tunes the pattern of each region and determines the different cell fates within them. In this review, we explore the function of the Wnt/β-catenin pathway during the formation of these specific posterior neural regions. We have examined the important transcriptional targets of the Wnt/β-catenin pathway acting downstream to mediate its morphogenetic activity. Different regulatory networks are activated in different posterior neural regions, and these networks induce specific neural cell types in each region. Eludidating how each of these networks specify different cell fates is crucial for understanding the basic tenets of how Wnt morphogenetic activity induces the posterior nervous system during the earliest stages of vertebrate development.