Raccoon City: a remote mountain community suddenly besieged by a rash of grisly murders. At the epicenter, a dark secluded mansion belonging to the mysterious Umbrella Corporation. Deployed to investigate the strange goings-on is the Special Tactics and Rescue Squad (S.T.A.R.S.) but what unfolds as the team penetrate the mansion’s long-locked doors is terror beyond their worst nightmares.

Combat medic and biochemist Rebecca Chambers, the sole survivor of Bravo Team, joins a new S.T.A.R.S. strike force when rumor comes of another Umbrella experiment: hidden beneath the rocky cliffs of Caliban Cove, Maine, someone is building an army of the undead. Now the S.T.A.R.S. must battle more unspeakable horrors and stop a madman from unleashing the biohazard upon the world.

Beneath the deserts of the American Southwest, one of the Umbrella Corporation's most elaborate facilities is about to go online. Somewhere inside may also be the key to stopping Umbrella once and for all... can Leon Kennedy, Claire Redfield, Rebecca Chambers, and their friends can get past a strike team of corrupt S.T.A.R.S., and survive the genetically engineered horrors awaiting them?

A remote mountain community is suddenly beseiged by a rash of grisly murders encroaching upon it from the surrounding forest. Bizarre reports start to spread, describing attacks from viscious creatures, some human...some not. At the centre of these deaths is a dark, secluded mansion belonging to the mysterious Umbrella Corporation. For years Umbrella has laboured within the mansion, unwatched, ostensibly conducting benign genetic research. Deployed to investigate the strange goings on is the Special Tactics and Rescue Squad (S.T.A.R.S), a paramilitary response unit boasting an unusual array of mission specialists. They believe they are ready for anything but nothing prepares them for the terror which awaits them when they penetrate the mansions long-locked doors. Behind the horror of nightmare creatures, results of forbidden experiments gone disasterously wrong, lies a conspiracy so vast in its scope and so insidious in its agenda that the S.T.A.R.S will be betrayed from within to ensure that the world never learns Umbrella's secret. And if any survive...they may well come to envy those who do not.

Leon Kennedy, a rookie cop on a new assignment, and Claire Redfield, sister of the still-missing S.T.A.R.S. member Chris, arrive at Raccoon City to discover a necropolis. A botched attempt by the Umbrella Corporation to retrieve a devastating mutagenic weapon has resulted in a horrifying viral outbreak, transforming the city’s population into the living dead. And all of them are hungry.

Claire Redfield’s desperate search for her missing brother leads her to a remote island, where a mad genius has unleashed every grotesque creature at his disposal to stop her from interfering with his horrific agenda. Meanwhile, Chris Redfield has been fighting a one-man war against Umbrella’s creations... and is now on a collision course with the man who betrayed the S.T.A.R.S. in Raccoon City.

Following the events of Resident Evil: Apocalypse, the beautiful, dangerous, enigmatic Alice returns, and this time she and her fellow survivor Carlos Olivera are running with a pack of humans led by a new ally, Claire Redfield. Together they are cutting through the wastelands of the United States on a long trek to Alaska. Hunted by the minions of the scheming Dr. Isaacs, Alice has zombies hungry for her flesh and the Umbrella Corporation's monstrous lab rats hungry for her blood...while Alice herself hungers only for revenge.