This guide to the treatment of even the most complex patients with primary glomerular diseases is full of practical information collected and organised in an easy-to-read manner, containing not only an evidence-based review of the topic but also practical recommendations from experts in the field

Glomerulonephritis is one of the commonest causes of end-stage renal failure worldwide. Although there have been considerable advances in the management of renal failure by dialysis and transplantation, there has been relatively little progress in its prevention. This volume sets out to review current practice in the treatment of glomerulonephritis, which is aimed both at controlling the clinical manifestations, e.g. nephrotic syndrome, and at preventing the progression to renal failure. The term glomerulonephritis covers a wide range of conditions with different immunological, histological and clinical features. This volume therefore starts with reviews of the immunology and pathology of different types of glomerulonephritis. This is followed by detailed consideration of the treatment of the commoner primary and secondary forms of the disease. There are separate chapters on special circumstances, such as glomerulonephritis in pregnancy or following renal transplantation. In each chapter, attempts are made to review the evidence for the effectiveness of treatment, based on controlled trials, immunopathological principles and the authors' considerable experience. Although some aspects of the treatment of glomerulonephritis can be found in the standard texts on renal disease, this volume provides an up-to-date, thoroughly referenced, and practical guide to management. As such, it should be of value to nephrologists and general physicians, including those in training, and to postgraduate students of nephrology.

This volume, written by well-known experts in the field, covers all aspects of Anti-Neutrophil Cytoplasmic Antibody (ANCA) Associated Vasculitis (AAV). The expression refers to a group of diseases, characterized by destruction and inflammation of small vessels. The clinical signs vary and affect several organs, such as the kidney, lung, skin, nervous system and others. The opening chapters give some historical hints, explain the genetic basis of the disease and provide insights into the pathogenesis derived from recent experimental studies and guides the reader through classification and nomenclature. A large part of the book is then devoted to a detailed description of the specific related diseases and their clinical presentations, the disease course, and potential complications. The advice regarding treatment is based on the best currently available evidence in this constantly evolving area. The book is part of Springer’s series Rare Diseases of the Immune System, which presents recently acquired knowledge on pathogenesis, diagnosis, and therapy with the aim of promoting a more holistic approach to these conditions. AAVs are systemic autoimmune diseases of unknown cause that affect small (to medium) sized blood vessels. They include granulomatosis with polyangiitis (formerly Wegener's granulomatosis), microscopic polyangiitis, and eosinophilic granulomatosis with polyangiitis (formerly Churg–Strauss syndrome). This volume will be an invaluable source of up-to-date information for all practitioners involved in the care of patients with these diseases.

Glomerulonephritis is a term referring to direct injury of the glomeruli with resulting disturbances of normal glomerular function, progressively leading to renal failure. Glomerular diseases are classified as primary, where glomerular damage is the prime disturbance, with extrarenal manifestations as a result of renal impairment, and secondary, following systemic disorders, infections or exposure to certain drugs. Although noteworthy progress has been made in the past years in the symptomatic and specific treatment, therapy of both primary and secondary glomerulonephritis can be challenging. Management of these patients requires early diagnosis, expert knowledge of the immunosuppressive agents and other drugs currently available for the treatment of each glomerulonephritis, consideration of possible adverse reactions to these drugs, alternative therapeutic strategies in cases of hyporesponsiveness or non-responsiveness of the patient to the treatment, and possible relapses of the disease. This book reviews knowledge of the main primary and secondary glomerulonephritis, with emphasis on current therapeutic strategies and practical recommendations. Glomerulonephritis are grouped according the presence or absence of proliferative histological alternations into primary and secondary proliferative and non-proliferative types. Each chapter deals with etiopathogenesis, epidemiology, pathology, clinical manifestations, natural history and therapeutic options of the commonest primary and secondary glomerular diseases, with exception the last chapter that covers inherited diseases with renal involvement. An atlas of the pathology of the glomerular diseases discussed completes this work.

This handbook covers all aspects of dialysis treatment and the care of patients with renal failure in a clear, compact but detailed format.

An algorithmic approach to interpreting renal pathology, updated in light of recent advances in understanding and new classification schemes.

Experts in the field of renal disease offer careful pathologic descriptions, appropriate clinical correlations, and extensive discussions on causes and pathogenesis to clarify the clinicians understanding and help facilitate easy, accurate diagnosis. This updated edition features hundreds of razor-sharp illustrations along with more international contributors than before.