Offering a global, multidisciplinary perspective on this life-threatening medical emergency, The Sepsis Codex provides a concise yet comprehensive look at a complex topic. Nearly 20% of global deaths are attributed to sepsis annually, nearly half of which are in children under the age of five, with low-resource settings being disproportionately affected. A “one size fits all approach is not sufficient to meet individual patients’ needs, instead requiring a therapeutic approach that considers different ages, predisposing factors, genetic traits, and more. This cutting-edge resource brings you up to date with recent medical advances in this challenging area. Covers pathophysiology, early detection, biomarkers and diagnosis, therapies, controversies, future research, the use of AI, professional organizations and public health in sepsis. Includes chapters on sepsis in special populations such as in pregnant women, transplanted patients, and children. Consolidates today's available information on this timely topic into a single, convenient resource.

Offering a global, multidisciplinary perspective on this life-threatening medical emergency, The Sepsis Codex provides a concise yet comprehensive look at a complex topic. Nearly 20% of global deaths are attributed to sepsis annually, nearly half of which are in children under the age of five, with low-resource settings being disproportionately affected. A "one size fits all" approach is not sufficient to meet individual patients' needs, instead requiring a therapeutic approach that considers different ages, predisposing factors, genetic traits, and more. This cutting-edge resource brings you up to date with recent medical advances in this challenging area. Covers pathophysiology, early detection, biomarkers and diagnosis, therapies, controversies, future research, the use of AI, professional organizations and public health in sepsis. Includes chapters on sepsis in special populations such as in pregnant women, transplanted patients, and children. Consolidates today's available information on this timely topic into a single, convenient resource.

This practically oriented book provides an up-to-date overview of all significant aspects of the pathogenesis of sepsis and its management, including within the intensive care unit. Readers will find information on the involvement of the coagulation and endocrine systems during sepsis and on the use of biomarkers to diagnose sepsis and allow early intervention. International clinical practice guidelines for the management of sepsis are presented, and individual chapters focus on aspects such as fluid resuscitation, vasopressor therapy, response to multiorgan failure, antimicrobial therapy, and adjunctive immunotherapy. The closing section looks forward to the coming decade, discussing novel trial designs, sepsis in low- and middle-income countries, and emerging management approaches. The book is internatio nal in scope, with contributions from leading experts worldwide. It will be of value to residents and professionals/practitioners in the fields of infectious diseases and internal medicine, as well as to GPs and medical students.

Drs. John C. Perkins and Michael E. Winters have assembled an expert team of authors on the topic of Sepsis in the Emergency Department. Article topics include: Defining and Diagnosing Sepsis; Appropriate Antibiotic Therapy; Severe Sepsis Resuscitation in Resource Limited Settings; Source Control in Severe Sepsis; Considerations in Special Populations with Severe Sepsis; Pediatric Severe Sepsis Resuscitation; The New Usual Care; Prehospital Sepsis Care; Endpoints of Sepsis Resuscitation; Pitfalls in the Diagnosis, Treatment, and Disposition of Severe Sepsis; Biomarkers in Sepsis; Vasopressors and Inotropes in Sepsis; and Sepsis Quality Measures and Performance Improvement.

Sepsis (or septic shock) is one of the leading post-surgical or post-traumatic complications in today's hospitals. This pervasive condition is the major cause of morbidity and mortality in intensive care units worldwide, as well as the leading cause of death in non-coronary patients. This is a concise, practical soft cover volume devoted to covering only the most practical information for physicians. Charts, tables, and other figures are used to illustrate easy-to-follow treatment guidelines for those professionals who regularly treat patients in the ICU.

This textbook is written at the dawn of a new era in the management of sepsis. Recent achievements in the clinical management of septic shock are the culmination of decades of basic and applied research by innovative researchers and clinical investigators worldwide. The contributing authors to this book have spearheaded much of this research and the Editors have endeavored to create a textbook that is comprehensive in nature while maintaining a specific focus upon the multitude of work that constitutes the spectrum of sepsis research including: pathophysiology; monitoring systems; general support; microbial aspects; complications; and anti-sepsis therapies.

Despite the progress that has been made in intensive care medicine, sepsis and septic shock are still accompanied by a high mortality rate. In recent years, new therapeutic approaches have been developed on the basis of a better understanding of this complex condition. This monograph contains contributions by well-known scientists and clinicians in the fields of hygienics, microbiology, infectious diseases, physiology, surgery and intensive care medicine. It provides an up-to-date overview of the etiology, pathophysiology, prevention, and therapy of sepsis and its complications.