The Saga of Quest Inc.: The New Q.I. follows Phils surprising discovery of his grandfathers secret life and his fight against mysterious foes. Phil vows to avenge his grandfathers death and to emulate his fight against evil. Together with his grandfathers compatriots, and friends of his own, he reforms Quest Inc. with surprising consequences. A multitude of adventures lead him into time travel, monsters, and the quest for the Chalice of Youth (Fountain of Youth).

After Phil returns home from college he finds out that things have changed. Muggsy has gone back to old habits and Isaiah, Brandon and Madison are the new junior commanders of Quest Inc. But when the son of the highest evil threatens Quest Inc. and the world, Phil must join Q.I. as head junior commander again. Can Phil and Quest Inc. retrieve the Spear of Destiny and save our world or will the world end by demons.