Explores the origins of contemporary drug regulation and the modern clinical trial.

Improving your craft is a key skill for product and user experience professionals working in the digital era. There are many established methods of product development to inspire and focus teams—Sprint, Lean, Agile, Kanban—all of which focus on solutions to customer and business problems. Enter XDPD, or Experiment-Driven Product Development—a new approach that turns the spotlight on questions to be answered, rather than on solutions. Within XDPD, discovery is a mindset, not a project phase. In Experiment-Driven Product Development, author Paul Rissen introduces a philosophy of product development that will hone your skills in discovery, research and learning. By guiding you through a practical, immediately applicable framework, you can learn to ask, and answer, questions which will supercharge your product development, making teams smarter and better at developing products and services that deliver for users and businesses alike. When applying the XDPD framework within your organization, the concept of an experiment—a structured way of asking, and answering, questions—becomes the foundation of almost everything you do, instilling a constant sense of discovery that keeps your team inspired. All types of activities, from data analysis to writing software, are seen through the lens of research. Rather than treating research as a separate task from the rest of product development, this book approaches the entire practice as one of research and continuous discovery. Designing successful experiments takes practice. That’s where Rissen’s years of industry expertise come in. In this book, you are given step-by-step tools to ensure that meaningful, efficient progress is made with each experiment. This approach will prove beneficial to your team, your users, and most importantly, to your product’s lasting success. Experiment-Driven Product Development offers a greater appreciation of the craft of experimentation and helps you adapt it in your own context. In our modern age of innovation, XDPD can put you ahead. Go forth and experiment! What You Will LearnKnow how to approach product development in a leaner, more efficient wayUnderstand where and when experiments can be useful, and how they fit into pre-existing organization environments and processesRealize why you should be thinking about the simplest, useful thing rather than the minimum, viable productDiscover how to break down feature and design ideas into the assumptions and the premises that lie behind themAppreciate the importance of designing your experiments, and the statistical concepts that underpin their successMaster the art of communicating the results of experiments back to stakeholders, and help the results guide what happens next Who This Book is For Professionals working in digital product design and development, user experience, and service design. This book is best suited for those who work on digital products every day and want to adopt better approaches to gaining knowledge about their users, what works, and what does not work.

What role have experiments played, and should they play, in physics? How does one come to believe rationally in experimental results? The Neglect of Experiment attempts to provide answers to both of these questions. Professor Franklin's approach combines the detailed study of four episodes in the history of twentieth century physics with an examination of some of the philosophical issues involved. The episodes are the discovery of parity nonconservation ( or the violation of mirror symmetry) in the 1950s; the nondiscovery of parity nonconservation in the 1930s, when the results of experiments indicated, at least in retrospect, the symmetry violation, but the significance of those results was not realized; the discovery and acceptance of CP ( combined parity-charge conjugations, paricle-antiparticle) symmetry; and Millikan's oil-drop experiment. Franklin examines the various roles that experiment plays, including its role in deciding between competing theories, confirming theories, and calling fo new theories. The author argues that one can provide a philosophical justification for these roles. He contends that if experiment plays such important roles, then one must have good reason to believe in experimental results. He then deals with deveral problems concerning such reslults, including the epistemology of experiment, how one comes to believe rationally in experimental results, the question of the influence of theoretical presuppositions on results, and the problem of scientific fruad. This original and important contribution to the study of the philosophy of experimental science is an outgrowth of many years of research. Franklin brings to this work more than a decade of experience as an experimental high-energy physicist, along with his significant contributions to the history and philosophy of science.

The modern classic of race and medicine updated with an additional chapter on the Tuskegee experiment's legacy in the age of AIDS.

Scientific experimentation with humans has a long history. Combining elements of history of science with history of medicine, The Uses of Humans in Experiment illustrates how humans have grappled with issues of consent, and how scientists have balanced experience with empiricism to achieve insights for scientific as well as clinical progress. The modern incarnation of ethics has often been considered a product of the second half of the twentieth century, as enshrined in international laws and codes, but these authors remind us that this territory has long been debated, considered, and revisited as a fundamental part of the scientific enterprise that privileges humans as ideal subjects for advancing research.

NATIONAL BOOK CRITICS CIRCLE AWARD WINNER • The first full history of Black America’s shocking mistreatment as unwilling and unwitting experimental subjects at the hands of the medical establishment. No one concerned with issues of public health and racial justice can afford not to read this masterful book. "[Washington] has unearthed a shocking amount of information and shaped it into a riveting, carefully documented book." —New York Times From the era of slavery to the present day, starting with the earliest encounters between Black Americans and Western medical researchers and the racist pseudoscience that resulted, Medical Apartheid details the ways both slaves and freedmen were used in hospitals for experiments conducted without their knowledge—a tradition that continues today within some black populations. It reveals how Blacks have historically been prey to grave-robbing as well as unauthorized autopsies and dissections. Moving into the twentieth century, it shows how the pseudoscience of eugenics and social Darwinism was used to justify experimental exploitation and shoddy medical treatment of Blacks. Shocking new details about the government’s notorious Tuskegee experiment are revealed, as are similar, less-well-known medical atrocities conducted by the government, the armed forces, prisons, and private institutions. The product of years of prodigious research into medical journals and experimental reports long undisturbed, Medical Apartheid reveals the hidden underbelly of scientific research and makes possible, for the first time, an understanding of the roots of the African American health deficit. At last, it provides the fullest possible context for comprehending the behavioral fallout that has caused Black Americans to view researchers—and indeed the whole medical establishment—with such deep distrust.

Novel collection of essays addressing contemporary trends in political science, covering a broad array of methodological and substantive topics.