This volume provides documentations for the established MAK values (maximum workplace concentrations) of selected occupational toxicants, including an authoritative review of the available toxicological studies and data. For each substance, the toxic effects, mechanisms and modes of action, toxicogenetics and metabolism, effects in man and animals are described. In addition, the carcinogenic, germ-cell mutagenic, sensitizing or skin-resorptive effects as well as their toxicity to the reproductive system are evaluated, plus basic physico-chemical data are provided. The documentations are thus not only essential for the application of MAK values but also provide a concise toxicological overview for each substance.

This volume provides documentations for the established MAK values (maximum workplace concentrations) of selected occupational toxicants, including an authoritative review of the available toxicological studies and data. For each substance, the toxic effects, mechanisms and modes of action, toxicogenetics and metabolism, effects in man and animals are described. In addition, the carcinogenic, germ-cell mutagenic, sensitizing or skin-resorptive effects as well as their toxicity to the reproductive system are evaluated, plus basic physico-chemical data are provided. The documentations are thus not only essential for the application of MAK values but also provide a concise toxicological overview for each substance.

This volume provides documentations for the established MAK values (maximum workplace concentrations) of selected occupational toxicants, including an authoritative review of the available toxicological studies and data. For each substance, the toxic effects, mechanisms and modes of action, toxicogenetics and metabolism, effects in man and animals are described. In addition, the carcinogenic, germ-cell mutagenic, sensitizing or skin-resorptive effects as well as their toxicity to the reproductive system are evaluated, plus basic physico-chemical data are provided. The documentations are thus not only essential for the application of MAK values but also provide a concise toxicological overview for each substance.

This volume provides the documentations for the established BAT values and EKA, as well as for further biological exposure values, including an authoritative review of the available toxicological studies and data. For each substance, the metabolism and pharmacokinetics, critical toxicity, exposure and effects, suitable indicators of internal exposure, the evaluation of the BAT value and the correct interpretation of data are described. The basic physico-chemical data are also provided, making the documentations not only essential for the application of BAT values and EKA, but also provide a concise overview of biological monitoring for each substance.

This volume provides detailed, ready-to-use protocols for air monitoring methods, developed to monitor concentrations of occupational toxicants at the workplace, while they can also be used for environmental monitoring. All the methods are reliable, reproducible, adhere to quality assurance standards and cover all the required steps from sampling to the interpretation of results. This includes data on precision, accuracy, and detection limit, calibration procedures as well as potential sources of systematic errors. In addition, the advantages and disadvantages of each method are clearly outlined.

This volume provides the documentations for the established BAT values and EKA, as well as for further biological exposure values, including an authoritative review of the available toxicological studies and data. For each substance, the metabolism and pharmacokinetics, critical toxicity, exposure and effects, suitable indicators of internal exposure, the evaluation of the BAT value and the correct interpretation of data are described. The basic physico-chemical data are also provided, making the documentations not only essential for the application of BAT values and EKA, but also provide a concise overview of biological monitoring for each substance.