Coping with modern technology in the life sciences (biology and medicine) became a major issue for people living in the Twentieth Century, and continues to be so in the present century. Biotechnology creates new opportunities and possibilities, but also new dangers, risks, and ethical concerns. In this volume, ethical dilemmas in the context of a specific biomedical technology are discussed. Experts in ethics, philosophy, psychoanalysis, and medicine jointly investigated a field of prenatal and genetic research that seems particularly challenging: prenatal diagnostics. In many European countries amniocentesis, for example, is a routine diagnostic tool for women becoming pregnant after the age of thirty-five. In recent decades, enormous progress has been made in diagnosing genetically-based diseases and other serious prenatal abnormalities. Today, we know that a positive prenatal genetic diagnostic creates distress for all women and their partners, and necessitates making the difficult decision as to whether or not to allow the pregnancy to continue. As is demonstrated in this volume through the summaries of interviews with couples, the reactions of women and their partners who are facing this situation can be very different. The new and innovative interdisciplinary dialogue on this topic that is presented in this volume offers a deeper understanding of the ethical dilemmas raised by prenatal and genetic diagnostics, and explores ways to support couples in this extremely difficult situation.

For Jones the establishment of a definitive relationship between individual and society is central to the development of both engaged Buddhism and sociology. Here he tells readers how to bridge their spiritual practice to social action.

In a universe filled by chaos and disorder, one physicist makes the radical argument that the growth of order drives the passage of time -- and shapes the destiny of the universe. Time is among the universe's greatest mysteries. Why, when most laws of physics allow for it to flow forward and backward, does it only go forward? Physicists have long appealed to the second law of thermodynamics, held to predict the increase of disorder in the universe, to explain this. In The Janus Point, physicist Julian Barbour argues that the second law has been misapplied and that the growth of order determines how we experience time. In his view, the big bang becomes the "Janus point," a moment of minimal order from which time could flow, and order increase, in two directions. The Janus Point has remarkable implications: while most physicists predict that the universe will become mired in disorder, Barbour sees the possibility that order -- the stuff of life -- can grow without bound. A major new work of physics, The Janus Point will transform our understanding of the nature of existence.

Preeminent historian of medicine Owsei Temkin brought to his writing an awesome range of scholarship, for he was at home in the classical, the medieval, and the modern eras. The essays gathered in this volume deal with all the topics that Temkin considered most important in his work. They were widely commended for their originality, intelligent analysis, and impressive continuity of thought. Temkin explores the history of basic medical sciences, of health and disease, and of surgery and drug therapy, as well as general questions concerning the historical and philosophical approach to medicine from antiquity to the early twentieth century. In a retrospective introduction which gives the book its name, Temkin relates his writings to his career as a scholar in Germany and the United States. He situates the writings against the background of the development of the study of medical history and provides recollections of such prominent figures as Karl Sudhoff, Henry E. Sigerist, William H. Welch, and Richard H. Shryock.

Because aging is accompanied by a steady decline in resistance to infectious diseases, the diagnosis and treatment of these diseases in the elderly is not only much more complex, but also often quite different from that for younger patients. In the second edition of Infectious Disease in the Aging: A Clinical Handbook, a panel of well known and highly experienced geriatric physicians and infectious disease experts review the most important common infections affecting the elderly and delineate their well-proven diagnostic, therapeutic, and preventive techniques. Among the illnesses discussed are urinary tract infections, pneumonia, ocular infections, tuberculosis, and fungal and viral infections. In addition, there are detailed discussions of sepsis, infective endocarditis, intraabdominal infections, bacterial meningitis, osteomyelitis and septic arthritis, and prosthetic device infections.

Volume I.A An outbreak of a respiratory disease first reported in Wuhan, China in December 2019 and the causative agent was discovered in January 2020 to be a novel betacoronovirus of the same subgenus as SARS-CoV and named severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Coronavirus disease 2019 (COVID-19) has rapidly disseminated worldwide, with clinical manifestations ranging from mild respiratory symptoms to severe pneumonia and a fatality rate estimated around 2%. Person to person transmission is occurring both in the community and healthcare settings. The World Health Organization (WHO) has recently declared the COVID-19 epidemic a public health emergency of international concern. The ongoing outbreak presents many clinical and public health management challenges due to limited understanding of viral pathogenesis, risk factors for infection, natural history of disease including clinical presentation and outcomes, prognostic factors for severe illness, period of infectivity, modes and extent of virus inter-human transmission, as well as effective preventive measures and public health response and containment interventions. There are no antiviral treatment nor vaccine available but fast track research and development efforts including clinical therapeutic trials are ongoing across the world. Managing this serious epidemic requires the appropriate deployment of limited human resources across all cadres of health care and public health staff, including clinical, laboratory, managerial and epidemiological data analysis and risk assessment experts. It presents challenges around public communication and messaging around risk, with the potential for misinformation and disinformation. Therefore, integrated operational research and intervention, learning from experiences across different fields and settings should contribute towards better understanding and managing COVID-19. This Research Topic aims to highlight interdisciplinary research approaches deployed during the COVID-19 epidemic, addressing knowledge gaps and generating evidence for its improved management and control. It will incorporate critical, theoretically informed and empirically grounded original research contributions using diverse approaches, experimental, observational and intervention studies, conceptual framing, expert opinions and reviews from across the world. The Research Topic proposes a multi-dimensional approach to improving the management of COVID-19 with scientific contributions from all areas of virology, immunology, clinical microbiology, epidemiology, therapeutics, communications as well as infection prevention and public health risk assessment and management studies.