The second edition of Avian Immunology provides an up-to-date overview of the current knowledge of avian immunology. From the ontogeny of the avian immune system to practical application in vaccinology, the book encompasses all aspects of innate and adaptive immunity in chickens. In addition, chapters are devoted to the immunology of other commercially important species such as turkeys and ducks, and to ecoimmunology summarizing the knowledge of immune responses in free-living birds often in relation to reproductive success. The book contains a detailed description of the avian innate immune system, encompassing the mucosal, enteric, respiratory and reproductive systems. The diseases and disorders it covers include immunodepressive diseases and immune evasion, autoimmune diseases, and tumors of the immune system. Practical aspects of vaccination are examined as well. Extensive appendices summarize resources for scientists including cell lines, inbred chicken lines, cytokines, chemokines, and monoclonal antibodies. The world-wide importance of poultry protein for the human diet, as well as the threat of avian influenza pandemics like H5N1 and heavy reliance on vaccination to protect commercial flocks makes this book a vital resource. This book provides crucial information not only for poultry health professionals and avian biologists, but also for comparative and veterinary immunologists, graduate students and veterinary students with an interest in avian immunology. - With contributions from 33 of the foremost international experts in the field, this book provides the most up-to-date review of avian immunology so far - Contains a detailed description of the avian innate immune system reviewing constitutive barriers, chemical and cellular responses; it includes a comprehensive review of avian Toll-like receptors - Contains a wide-ranging review of the "ecoimmunology" of free-living avian species, as applied to studies of population dynamics, and reviews methods and resources available for carrying out such research

Microbial endocrinology represents a newly emerging interdisciplinary field that is formed by the intersection of the fields of neurobiology and microbiology. This book will introduce a new perspective to the current understanding not only of the factors that mediate the ability of microbes to cause disease, but also to the mechanisms that maintain normal homeostasis. The discovery that microbes can directly respond to neuroendocrine hormones, as evidenced by increased growth and production of virulence-associated factors, provides for a new framework with which to investigate how microorganisms interface not only with vertebrates, but also with invertebrates and even plants. The reader will learn that the neuroendocrine hormones that one most commonly associates with mammals are actually found throughout the plant, insect and microbial communities to an extent that will undoubtedly surprise many, and most importantly, how interactions between microbes and neuroendocrine hormones can influence the pathophysiology of infectious disease.

This book discusses how this will affect the use/non-use practice of AGPs.

Livestock production is changing worldwide. Amongst the changes are those instigated by legislation such as restrictions on antibiotics and antibiotic growth promoters, well fare regulations, etc., all forcing livestock producers to adapt to new husbandry, management, nutrition and healthcare techniques. Food safety is an explosive political issue. The expectations and demands of the informed consumer have altered perceptions of risk and brought food safety to the very front and centre of politics. The gastrointestinal tract is essential in the maintenance of health, wellbeing and production in livestock. The above changes impact feed formulation. The industry looks for alternatives to maintain intestinal health and maximise animal performance, whilst complying with increasingly stringent legislation. This requires a good understanding of the physiological processes involved. In this book, the current knowledge in the major monogastric production species (pigs and chicken) is reviewed by renowned experts in the field. It describes infectious and non-infectious challenges as well as the complex interaction between innate, cellular and humoral immunity and performance. The problems that this complexity poses concerning the identification of important factors for intestinal health are discussed. 'Intestinal health' also reviews promising new approaches such as the use and development of validated biomarkers, and the application of omics techniques and systems biology.

Although we can't usually see them, microbes are essential for every part of human life-indeed all life on Earth. The emerging field of metagenomics offers a new way of exploring the microbial world that will transform modern microbiology and lead to practical applications in medicine, agriculture, alternative energy, environmental remediation, and many others areas. Metagenomics allows researchers to look at the genomes of all of the microbes in an environment at once, providing a "meta" view of the whole microbial community and the complex interactions within it. It's a quantum leap beyond traditional research techniques that rely on studying-one at a time-the few microbes that can be grown in the laboratory. At the request of the National Science Foundation, five Institutes of the National Institutes of Health, and the Department of Energy, the National Research Council organized a committee to address the current state of metagenomics and identify obstacles current researchers are facing in order to determine how to best support the field and encourage its success. The New Science of Metagenomics recommends the establishment of a "Global Metagenomics Initiative" comprising a small number of large-scale metagenomics projects as well as many medium- and small-scale projects to advance the technology and develop the standard practices needed to advance the field. The report also addresses database needs, methodological challenges, and the importance of interdisciplinary collaboration in supporting this new field.

In recent years the gastrointestinal microflora has featured strongly in scientific, veterinary and medical research. As a result it has become obvious that the gut microflora is an essential component of the healthy animal. Not only is it involved in digestion of food, it is essential for the optimal resistance to disease. The first part of this book records the research that has been done on the factors affecting colonization of the gut and the effect that the flora has on the host animal. The second part discusses the way in which this basic knowledge affects the choice of organism being used as a probiotic. The evidence for the involvement of the gut microflora in the health and well-being of the animal is incontrovertible, but the development of probiotics has been largely empirical, failing to capitalize on the relevant research data. The bringing together of the basic information on gut microecology and the development of probiotic preparations is long overdue. It is hoped that this exercise will result in a more scientific approach to probiotic development and the emergence of new and improved preparations for animals and man. The authors involved are all experts in their field and I am greatly indebted to them for their contributions to the book. R. Fuller Abbreviations used for - generIc names Aspergillus A.B. Bacillus Bact. Bacteroides Bifidobacterium Bif. C. Clostridium Cam. Campylobacter Can. Candida Cor. Corynebacteri urn E. Escherichia Enterobacter Eb. Ent. Enterococcus Fusobacterium F. Fib. Fibrobacter K. Klebsiella 1.