Supergirl gets a job as a secretary for one of the faculty advisors at Lake Shore University and also has to deal with a villain named Decay who can destroy with a touch in "Decay Day."

Brains, a member of the Gang, has managed to elude Supergirl and, while fleeing, discovers a secret operation which includes a giant robot that has attacked Chicago's O'Hare Airport. So it's up to Supergirl to save the day in "Battleground O'Hare."

One-year anniversary issue in which Supergirl gets a new costume and also has to help a neighbor, Mrs. Berkowitz who is being threatened by a group of fanatics with a leader who may be more than she appears in "Echoes of Times Gone By."

With the new Doom Patrol as guest stars in this issue, Supergirl battles Reactron, the Living Reactor who is able to command all forms of radiation. And stopping Reactron may be fatal to Supergirl in "Re-Enter: Reactron."

Supergirl, as Linda Danvers, moves to Chicago to begin a new life as a student at Lake Shore University. She gets a new home there and makes new friends and also meets a new villain in "A Very Strange and Special Girl."

The Gang has mesmerized Supergirl into believing that she is in danger of exposing her secret identity. So she has to conquer that fear in order to defeat the Gang in "Fear Times Four."

Supergirl continues her battle with Psi, a girl with powerful abilities who has been brainwashed into believing that Chicago must die, and also deals with her new friends where she is rooming in "Crisis Over Chicago."