Samuel Clark was born ca. 1710 in Ireland. He married Mary Ferrill in Delaware, ca. 1729. They had six children, ca. 1734-1766. He died in Bedford, Pennsylvania. Descendants lived in Pennsylvania, Iowa, Minnesota, South Dakota, California, Arizona and elsewhere.

John Owens Clark was born 1 February 1763 in Scotland. His parents were William Clark and Margaret Owens. His family emigrated and settled in Bedford County, Pennsylvania. John served in the American Revolution. He married Mary Blair in about 1783. They had eleven children. John died in Clarksburg, Ohio in 1811. Descendants and relatives lived mainly in Ohio, Indiana, Utah and Texas.

Thomas Clark, of Scottish lineage, immigrated from Scotland or Ireland to Cumberland County, Pennsylvania during or before 1750. He served in the French and Indian War, and probably was a colonel during the Revolutionary War. Descendants and relatives lived in Pennsylvania, Ohio, Indiana, Missouri, Kansas, Colorado, Iowa, Wisconsin and related families.