In the summer of 1982, hospital emergency rooms in the San Francisco Bay Area were suddenly confronted with mysteriously “frozen” patients – young men and women who, though conscious, could neither move nor speak. Doctors were baffled, until neurologist J. William Langston, recognizing the symptoms of advanced Parkinson’s disease, administered L-dopa – the only known effective treatment – and “unfroze” his patient. Dr. Langston determined that this patient and five others had all used the same tainted batch of synthetic heroin, inadvertently laced with a toxin that had destroyed an area of their brains essential to normal movement. This same area, the substantia nigra, slowly deteriorates in Parkinson’s disease. As scientists raced to capitalize on this breakthrough, Dr. Langston struggled to salvage the lives of his frozen patients, for whom L-dopa provided only short-term relief. The solution he found lay in the most daring area of research: fetal-tissue transplants. The astonishing recovery of two of his patients garnered worldwide press coverage, helped overturn federal restrictions on fetal-tissue research, and offered hope to millions suffering from Parkinson’s, Alzheimer’s, and other degenerative brain disorders. This is the story behind the headline – a spellbinding account that brings to life the intellectual excitement, ethical dilemmas, and fierce competitiveness of medical research. This new updated edition of the classic neurological mystery tale, “The Case of the Frozen Addicts,” illuminates how the solution to a baffling mystery of the brain’s chemistry opened a new frontier in medicine and restored life to people without hope. “It begins with a series of quixotic discoveries, escalates to providing possible solutions for one of humanity’s most intractable medical problems, and then catapults the reader into the center of America’s hottest political arena – abortion and fetal sanctity. Bravo! A brilliant read.” – Laurie Garrett, author of The Coming Plague “[Langston and Palfreman] weave a highly readable and spellbinding medical detective tale... It is as absorbing as a good mystery, as entertaining as an exciting novel, and as enlightening as a good biography.” – Stanley Fahn, New England Journal of Medicine “I could not put it down... it is the lives of the ‘frozen addicts’ themselves – and the fullness with which this is presented – which makes the whole thing overwhelming.” – Oliver Sacks

“The best and clearest book I’ve encountered on the current state of knowledge about Parkinson’s Disease . . . a master storyteller.” —The Tampa Tribune Seven million people worldwide suffer from Parkinson’s, and doctors, researchers, and patients continue to hunt for a cure. In Brain Storms, Peabody Award–winning journalist Jon Palfreman tells their story—a story that became his own when he was diagnosed with the debilitating illness. Palfreman chronicles how scientists have worked to crack the mystery of what was once called the shaking palsy, from the earliest clinical descriptions of tremors, gait freezing, and micrographia to the cutting edge of neuroscience, and charts the victories and setbacks of a massive international effort to best the disease. He takes us back to the 1950s and the discovery of L-dopa. He delves into other therapeutic approaches to this perplexing condition, from partial lobotomies and deep brain stimulation to neural grafting. And he shares inspiring stories of brave individuals living with Parkinson’s, from a former professional ballet dancer who tricks her body to move freely again to a patient who cannot walk but astounds doctors when he rides a bicycle with no trouble at all. The race is on to stop or reverse neurodegenerative conditions like Parkinson’s and Alzheimer’s. Brain Storms is the long-overdue, riveting, and deeply personal story of that race, and a passionate, insightful look into the lives of those affected. “Well written and poignant.” —The Wall Street Journal “[Palfreman] has an excellent grasp on the science behind the disease . . . but it is as a human story that the book is most compelling.” —The Times Literary Supplement “Clean prose, clear thought and fascinating stories.” —The Miami Herald “Extraordinary case studies abound.” —Nature “Fast-paced, captivating . . . part scientific investigation, part medical detective story, and part memoir . . . it opens wide a window into the world of Parkinson’s.” —Publishers Weekly (starred review)

Jealousy turns deadly in this chilling story from the author of Whatever Happened to Janie? As kids, Meghan, West, and Lannie played freeze tag—but with Lannie, nothing was normal. With one touch, she could turn anyone as cold as ice, a human statue frozen in time. Years later, they’re in high school and everyone remembers Lannie’s power as a silly childhood fantasy. But when Meghan and West become the perfect couple, Lannie intends to collect on a promise West made her all those years ago: If he doesn’t love her, she’ll freeze Meghan—and this time it will be forever. Known for her intense, emotional thrillers like The Face on the Milk Carton, Caroline B. Cooney once again delivers an addictive, spine-tingling tale of love gone wrong. This ebook features an illustrated biography of Caroline B. Cooney including rare images and never-before-seen documents from the author’s personal collection.

WARNING: THIS VIDEO GAME MAY IMPAIR YOUR JUDGMENT. IT MAY CAUSE SLEEP DEPRIVATION, ALIENATION OF FRIENDS AND FAMILY, WEIGHT LOSS OR GAIN, NEGLECT OF YOUR BASIC NEEDS AS WELL AS THE NEEDS OF LOVED ONES AND/OR DEPENDENTS, AND DECREASED PERFORMANCE ON THE JOB. THE DISTINCTION BETWEEN FANTASY AND REALITY MAY BECOME BLURRED. PLAY AT YOUR OWN RISK. NOT RESPONSIBLE FOR SUICIDE ATTEMPTS. No such warning was included on the latest and greatest release from the Warcraft series of massive multiplayer online role-playing games—World of Warcraft (WoW). So when Ryan Van Cleave—a college professor, husband, father, and one of the 11.5 million Warcraft subscribers worldwide—found himself teetering on the edge of the Arlington Memorial Bridge, he had no one to blame but himself. He had neglected his wife and children and had jeopardized his livelihood, all for the rush of living a life of high adventure in a virtual world. A fabulously written and gripping tale, Unplugged takes you on a journey through the author's semireclusive life with video games at the center of his experiences. Even when he was sexually molested by a young school teacher at age eleven, it was the promise of a new video game that had lured him to her house. As Ryan's life progresses, we witness the evolution of video games—from simple two-button consoles to today's multikey technology, brilliantly designed to keep the user actively participating. For Ryan, the virtual world was a siren-song he couldn't ignore, no matter the cost. As is the case with most recovering addicts, Ryan eventually hit rock bottom and shares with you his ongoing battle to control his impulses to play, providing prescriptive advice and resources for those caught in the grip of this very real addiction.

There's a bitter wind brewing in Buffalo, New York and it's blowing in more than just snow. "Little Skag" Farino, the last don of the local crime family, wants Kurtz dead and is sending in platoons of hit men, starting with the Attica Three Stooges and working up through more competent killers. Little Skag's beautiful sister, Angelina Farino Ferrara, is back from seven years in Sicily and has her own deadly agenda for Kurtz. If that isn't enough, Kurtz is approached by a dying concert violinist who wants his daughter's killer found. Rejecting the case at first, he is soon on the trail of a man who's not just the murderer of one child, but a cold-blooded serial killer who is a master of alternate identities and has the power to send a hundred men after Kurtz. As the bodies pile up like cords of wood, Hard Freeze hits town with the power of a whiteout blizzard and builds to a truly chilling climax. This is a crime novel where trigger fingers freeze to blue steel.

No one is coming to your aid. We have ensured this. Six strangers wake up on a remote island in the Florida Keys with no memory of their arrival. They soon discover their common bond: all of them are heroin addicts. As the first excruciating pangs of withdrawal make themselves felt, the six notice a yacht anchored across open water. On it lurk four shadowy figures, protected by the hungry sharks that patrol the waves. So begins a dangerous game. The six must undertake the impossible—swim to the next island where a cache of heroin awaits, or die trying. When alliances form, betrayal is inevitable. As the fight to survive intensifies, the stakes reach terrifying heights—and their captors’ motives finally begin to emerge.