"Summer school is in session on Ellesmere Island, and Martha, one of Edie Kiglatuk's students, is missing. When Martha's body turns up in Lake Turngaluk, Edie and her sidekick, Derek Palliser, promise the grieving family they'll deliver justice. But Martha's deeply traditional Inuit father spurns them as outsiders. Meanwhile, bullheaded lawyer Sonia Gutierrez is on her own crusade to investigate Lake Turngaluk's decades-old toxicity. Was one of the soldiers stationed near the lake involved in Martha's murder? Or is a larger conspiracy afoot--one involving the Canadian government? Edie, Sonia, and Derek clamber over the rocky Arctic terrain under the twenty-four-hour summer sun to find Martha's killer, but not without risking their own lives in the pursuit."--Back cover.

This highly successful manual has served for nearly three decades as the definitive guide to the safe use of radioactive materials. Completely revised and updated, the fourth edition presents a new dimension by adding coverage of nonionizing radiation, and is thus concerned with the entire field of radiation protection. The author takes the novel approach of introducing the whole range of energies possessed by particles and electromagnetic waves at the beginning of the text, thus integrating coverage of ionizing and nonionizing radiation rather than considering them as two separate disciplines. He goes on to cover the entire spectrum of radiation sources, including radionuclides, x-ray machines, accelerators, nuclear reactors, power lines, microwave towers, and cellular phones. With its expanded coverage, including a broader focus on public health issues, this new volume will serve as an important training and reference resource, not only for research scientists, physicians, and engineers, but for regulatory officials, attorneys, engineers, and environmental health and safety professionals. The breadth of citations alone makes this resource invaluable.

Mathematical modelling is an important part of nuclear medicine. Therefore, several chapters of this book have been dedicated towards describing this topic. In these chapters, an emphasis has been put on describing the mathematical modelling of the radiation transport of photons and electrons, as well as on the transportation of radiopharmaceuticals between different organs and compartments. It also includes computer models of patient dosimetry. Two chapters of this book are devoted towards introducing the concept of biostatistics and radiobiology. These chapters are followed by chapters detailing dosimetry procedures commonly used in the context of diagnostic imaging, as well as patient-specific dosimetry for radiotherapy treatments. For safety reasons, many of the methods used in nuclear medicine and molecular imaging are tightly regulated. Therefore, this volume also highlights the basic principles for radiation protection. It discusses the process of how guidelines and regulations aimed at minimizing radiation exposure are determined and implemented by international organisations. Finally, this book describes how different dosimetry methods may be utilized depending on the intended target, including whole-body or organ-specific imaging, as well as small-scale to cellular dosimetry. This text will be an invaluable resource for libraries, institutions, and clinical and academic medical physicists searching for a complete account of what defines nuclear medicine. The most comprehensive reference available providing a state-of-the-art overview of the field of nuclear medicine Edited by a leader in the field, with contributions from a team of experienced medical physicists, chemists, engineers, scientists, and clinical medical personnel Includes the latest practical research in the field, in addition to explaining fundamental theory and the field's history

This volume is the result of the concerted effeort of a number os scientists to summarize in a succinct way the current understanding of the mechanisms of these localizations. The editors of the book gratefully acknowledge this combined effort.

The last three decades have provided opportunities to explore the potential of treating malignant diseases with antibodies or other targeting molecules labelled with nuclides. While considerable advances have been reported, there is still a signi- cant amount of work left to accomplish before our ambitions can be achieved. It now seems timely to review the accomplishments achieved to date and to clarify the challenges that remain. The choice of radionuclide, the conjugation p- cedure employed, and the selection of suitable targets were early issues that were faced by our field that still persist, however we can now tackle these obstacles with significantly better insight. The expanding array of new targeting molecules (recombinant antibodies, peptides and agents based upon alternate scaffolds) may increase the therapeutic efficacy or even modify the radiation sensitivity of the targeted tumor cell. The title of this book “Targeted Radionuclide Tumour Therapy – Biological Aspects” was selected to reinforce the concept that a major focus of this volume was devoted to understanding the biological effects of targeting and radiation. These important issues have not previously been the primary focus in this context. Furthermore, our rapidly expanding knowledge of different types of cell death and the increasingly likely existence of cancer stem cells suggests to us that even more efficient approaches in targeting might be possible in the future.