Antibody-based therapeutics are a central driver of the success of biopharmaceuticals. The discovery technology of this field is isolated to a limited number of centers of excellence in industry and academia. The objective of this volume is to provide a series of guides to those evaluating and preparing to enter particular areas within the field. Each chapter is written with a historical perspective that sets into context the significance of the key developments, and with the provision of “points to consider” for the reader as a value-added feature of the volume. All contributors are experts in their fields and have played pivotal roles in the creation of the technology.

Providing practical and proven solutions for antibody-drug conjugate (ADC) drug discovery success in oncology, this book helps readers improve the drug safety and therapeutic efficacy of ADCs to kill targeted tumor cells. • Discusses the basics, drug delivery strategies, pharmacology and toxicology, and regulatory approval strategies • Covers the conduct and design of oncology clinical trials and the use of ADCs for tumor imaging • Includes case studies of ADCs in oncology drug development • Features contributions from highly-regarded experts on the frontlines of ADC research and development

Antibody-drug conjugates (ADCs) stand at the verge of a transformation. Scores of clinical programs have yielded only a few regulatory approvals, but a wave of technological innovation now empowers us to overcome past technical challenges. This volume focuses on the next generation of ADCs and the innovations that will enable them. The book inspires the future by integrating the field’s history with novel strategies and cutting-edge technologies. While the book primarily addresses ADCs for solid tumors, the last chapter explores the emerging interest in using ADCs to treat other diseases. The therapeutic rationale of ADCs is strong: to direct small molecules to the desired site of action (and away from normal tissues) by conjugation to antibodies or other targeting moieties. However, the combination of small and large molecules imposes deep complexity to lead optimization, pharmacokinetics, toxicology, analytics and manufacturing. The field has made significant advances in all of these areas by improving target selection, ADC design, manufacturing methods and clinical strategies. These innovations will inspire and educate scientists who are designing next-generation ADCs with the potential to transform the lives of patients.

This authoritative volume provides a holistic picture of antibody-drug conjugates (ADCs). Fourteen comprehensive chapters are divided into six sections including an introduction to ADCs, the ADC construct, development issues, landscape, IP and pharmacoeconomics, case studies, and the future of the field. The book examines everything from the selection of the antibody, the drug, and the linker to a discussion of developmental issues such as formulations, bio-analysis, pharmacokinetic-pharmacodynamic relationships, and toxicological and regulatory challenges. It also explores pharmacoecomonics and intellectual properties, including recently issued patents and the cost analysis of drug therapy. Case studies are presented for the three ADCs that have received FDA approval: gemtuzumab ozogamicin (Mylotarg®), Brentuximab vedotin (Adcetris®), and ado-trastuzumab emtansine (Kadcyla®), as well as an ADC in late-stage clinical trials, glembatumumab vedotin (CDX-011). Finally, the volume presents a perspective by the editors on the future directions of ADC development and clinical applications. Antibody-Drug Conjugates is a practical and systematic resource for scientists, professors, and students interested in expanding their knowledge of cutting-edge research in this exciting field.

This book discusses topics related to power electronics, especially electromagnetic transient analysis and control of high-power electronics conversion. It focuses on the re-evaluation of power electronics, transient analysis and modeling, device-based system-safe operating area, and energy balance-based control methods, and presenting, for the first time, numerous experimental results for the transient process of various real-world converters. The book systematically presents both theoretical analysis and practical applications. The first chapter discusses the structure and attributes of power electronics systems, highlighting the analysis and synthesis, while the second chapter explores the transient process and modeling for power electronics systems. The transient features of power devices at switching-on/off, transient conversion circuit with stray parameters and device-based system-safe operating area are described in the subsequent three chapters. The book also examines the measurement of transient processes, electromagnetic pulses and their series, as well as high-performance, closed-loop control, and expounds the basic principles and method of the energy-balanced control strategy. Lastly, it introduces the applications of transient analysis of typical power electronics systems. The book is valuable as a textbook for college students, and as a reference resource for electrical engineers as well as anyone working in the field of high-power electronics system.

The vast majority of computers in use today are encapsulated within other systems. In contrast to general-purpose computers that run an endless selection of software, these embedded computers are often programmed for a very specific, low-level and often mundane purpose. Low-end microcontrollers, costing as little as one dollar, are often employed by engineers in designs that utilize only a small fraction of the processing capability of the device because it is either more cost-effective than selecting an application-specific part or because programmability offers custom functionality not otherwise available. Embedded Systems Interfacing for Engineers using the Freescale HCS08 Microcontroller is a two-part book intended to provide an introduction to hardware and software interfacing for engineers. Building from a comprehensive introduction of fundamental computing concepts, the book suitable for a first course in computer organization for electrical or computer engineering students with a minimal background in digital logic and programming. In addition, this book can be valuable as a reference for engineers new to the Freescale HCS08 family of microcontrollers. The HCS08 processor architecture used in the book is relatively simple to learn, powerful enough to apply towards a wide-range of interfacing tasks, and accommodates breadboard prototyping in a laboratory using freely available and low-cost tools. In Part II: Digital and Analog Hardware Interfacing, hardware and software interfacing concepts are introduced. The emphasis of this work is on good hardware and software engineering design principles. Device drivers are developed illustrating the use of general-purpose and special-purpose digital I/O interfaces, analog interfaces, serial interfaces and real-time I/O processing. The hardware side of each interface is described and electrical specifications and related issues are considered. The first part of the book provides the programming skills necessary to implement the software in this part. Table of Contents: Introduction to the MC9S08QG4/8 Hardware / Analog Input / Serial Communication / Real-Time I/O Processing