Test No. 223: Avian Acute Oral Toxicity Test
Title | Test No. 223: Avian Acute Oral Toxicity Test PDF eBook |
Author | OECD |
Publisher | OECD Publishing |
Pages | 25 |
Release | 2010-07-23 |
Genre | |
ISBN | 9264090894 |
This Test Guideline describes procedures designed to estimate the acute oral toxicity of substances to birds, and it provides three testing options: (1) limit dose test, (2) LD50-slope test, and (3) LD50-only test. The LD50-slope and LD50-only ...
Ecological Effects Test Guidelines
Title | Ecological Effects Test Guidelines PDF eBook |
Author | |
Publisher | |
Pages | 9 |
Release | 1996 |
Genre | Chemicals |
ISBN |
Test No. 420: Acute Oral Toxicity - Fixed Dose Procedure
Title | Test No. 420: Acute Oral Toxicity - Fixed Dose Procedure PDF eBook |
Author | Organisation for Economic Co-operation and Development |
Publisher | |
Pages | 14 |
Release | 2002 |
Genre | |
ISBN |
A principle of the method is that in the main study only moderately toxic doses are used, and the administration of doses that are expected to be lethal should be avoided. This Guideline is intended primarily for use with rat. Groups of animals of a single sex (normally females) are dosed in a stepwise procedure using the fixed doses of 5, 50, 300 and 2000 mg/kg (exceptionally 5000 mg/kg). The initial dose level is selected on the basis of a sighting study as the dose expected to produce some signs of toxicity without causing severe toxic effects or mortality. Further groups of animals may be dosed at higher or lower fixed doses, depending on the presence or absence of signs of toxicity or mortality. This procedure continues until the dose causing evident toxicity or death is identified, or when no effects are seen at the highest dose or when deaths occur at the lowest dose. The test substance is administered in a single dose by gavage using a stomach tube or a suitable intubation canula. Animals should be fasted prior to dosing. A total of five animals of one sex will normally be used for each dose level investigated. The results of this study include: measurements (weighing at least weekly) and daily detailed observations, as well as gross necropsy. The method provides information on the hazardous properties and allows the substance to be classified for acute toxicity according to the Globally Harmonised System of classification and labelling of chemicals.
Handbook of Acute Oral Toxicity Testing Method
Title | Handbook of Acute Oral Toxicity Testing Method PDF eBook |
Author | Swapnil Satish Khadke |
Publisher | LAP Lambert Academic Publishing |
Pages | 76 |
Release | 2011-09 |
Genre | |
ISBN | 9783845477831 |
The purposes of acute toxicity testing are to obtain information on the biologic activity of a chemical and gain insight into its mechanism of action. The information on acute systemic toxicity generated by the test is used in hazard identification and risk management in the context of production, handling, and use of chemicals. For a classical LD50 study, laboratory mice and rats are the species typically selected. This book gives a short review of methods for acute toxicity testing with the emphasis on the Up and Down Method as per OECD Guidelines 425. Furthermore, this book consist of one research work on acute oral toxicity studies performed by authors.
Guidance Document on Acute Oral Toxicity Testing
Title | Guidance Document on Acute Oral Toxicity Testing PDF eBook |
Author | Organisation for Economic Co-operation and Development |
Publisher | |
Pages | 24 |
Release | 2002 |
Genre | |
ISBN |
This Guidance Document provides information for both the regulated community and regulators to assist with the choice of the most appropriate Guideline to enable particular data requirements to be met while reducing the number of animals used and animal suffering.
Recommended Guideline for Acute Oral Toxicity Testing in Rodents
Title | Recommended Guideline for Acute Oral Toxicity Testing in Rodents PDF eBook |
Author | |
Publisher | |
Pages | |
Release | 1981 |
Genre | |
ISBN |
Federal Register
Title | Federal Register PDF eBook |
Author | |
Publisher | |
Pages | 316 |
Release | 2013-05 |
Genre | Delegated legislation |
ISBN |