On March 3-4, 2016, the National Academies of Sciences, Engineering, and Medicine's Forum on Neuroscience and Nervous System Disorders held a workshop in Washington, DC, bringing together key stakeholders to discuss opportunities for improving the integrity, efficiency, and validity of clinical trials for nervous system disorders. Participants in the workshop represented a range of diverse perspectives, including individuals not normally associated with traditional clinical trials. The purpose of this workshop was to generate discussion about not only what is feasible now, but what may be possible with the implementation of cutting-edge technologies in the future.

Successful drug development relies on accurate and efficient clinical trials to deliver the best and most effective pharmaceuticals and clinical care to patients. However, the current model for clinical trials is outdated, inefficient and costly. Clinical trials are limited by small sample sizes that do not reflect variations among patients in the real world, financial burdens on participants, and slow processes, and these factors contribute to the disconnect between clinical research and clinical practice. On November 28-29, the National Academies of Sciences, Engineering, and Medicine convened a workshop to investigate the current clinical trials system and explore the potential benefits and challenges of implementing virtual clinical trials as an enhanced alternative for the future. This publication summarizes the presentations and discussions from the workshop.

An examination of the fierce disputes that arose in Britain in the decades around 1900 concerning patents for electrical power and telecommunications. Late nineteenth-century Britain saw an extraordinary surge in patent disputes over the new technologies of electrical power, lighting, telephony, and radio. These battles played out in the twin tribunals of the courtroom and the press. In Patently Contestable, Stathis Arapostathis and Graeme Gooday examine how Britain's patent laws and associated cultures changed from the 1870s to the 1920s. They consider how patent rights came to be so widely disputed and how the identification of apparently solo heroic inventors was the contingent outcome of patent litigation. Furthermore, they point out potential parallels between the British experience of allegedly patentee-friendly legislation introduced in 1883 and a similar potentially empowering shift in American patent policy in 2011. After explaining the trajectory of an invention from laboratory to Patent Office to the court and the key role of patent agents, Arapostathis and Gooday offer four case studies of patent-centered disputes in Britain. These include the mostly unsuccessful claims against the UK alliance of Alexander Graham Bell and Thomas Edison in telephony; publicly disputed patents for technologies for the generation and distribution of electric power; challenges to Marconi's patenting of wireless telegraphy as an appropriation of public knowledge; and the emergence of patent pools to control the market in incandescent light bulbs.

A house fire on a sweltering summer morning comes as no surprise, but when a body is found in the ruins, the Sanford police soon have the prime suspect in their sights. Evidence mounts, an arrest is made, and Joe Murray is at his wits' end before helps comes from an unexpected quarter. How could all the evidence be wrong? There's only one way. It was carefully constructed to point in the wrong direction, and Joe and his partner in crime-detection must pull out all the stops to prove it. The fourteenth Sanford 3rd Age Club Mystery, and it's Joe's toughest, most dangerous case yet. Now complete the collection. Grab the full, bestselling STAC series: THE FILEY CONNECTION THE I-SPY MURDERS A HALLOWEEN HOMICIDE A MURDER FOR CHRISTMAS MURDER AT THE MURDER MYSTERY WEEKEND MY DEADLY VALENTINE THE CHOCOLATE EGG MURDERS THE SUMMER WEDDING MURDER COSTA DEL MURDER CHRISTMAS CRACKERS DEATH IN DISTRIBUTION A KILLING IN THE FAMILY A THEATRICAL MURDER TRIAL BY FIRE And, by the same author: VOICES THE HANDSHAKER THE DEEP SECRET

The regulation of technology is an important and topical area of law, relevant to almost all aspects of society. Technology Law: Australian and International Perspectives presents a thorough exploration of the new legal challenges created by evolving technologies, from the use of facial recognition technology in criminal investigations to the rise and regulation of cryptocurrencies. A well-written and fascinating introduction to technology law in Australia and internationally, Technology Law provides thorough coverage of the theoretical perspectives, legislation, cases and developing issues where technology and the law interact. The text covers data protection and privacy, healthcare technology, criminal justice technology, commercial transactions, cybercrime, social media and intellectual property, and canvasses the future of technology and technology law. Written by leading experts in the field, Technology Law is an excellent resource for law students and legal professionals with an interest in the area.

Around the world, access to justice enjoys an energetic and passionate resurgence as an object both of scholarly inquiry and political contest, as both a social movement and a value commitment motivating study and action. This work evidences a deeper engagement with social theory than past generations of scholarship.

Data sharing can accelerate new discoveries by avoiding duplicative trials, stimulating new ideas for research, and enabling the maximal scientific knowledge and benefits to be gained from the efforts of clinical trial participants and investigators. At the same time, sharing clinical trial data presents risks, burdens, and challenges. These include the need to protect the privacy and honor the consent of clinical trial participants; safeguard the legitimate economic interests of sponsors; and guard against invalid secondary analyses, which could undermine trust in clinical trials or otherwise harm public health. Sharing Clinical Trial Data presents activities and strategies for the responsible sharing of clinical trial data. With the goal of increasing scientific knowledge to lead to better therapies for patients, this book identifies guiding principles and makes recommendations to maximize the benefits and minimize risks. This report offers guidance on the types of clinical trial data available at different points in the process, the points in the process at which each type of data should be shared, methods for sharing data, what groups should have access to data, and future knowledge and infrastructure needs. Responsible sharing of clinical trial data will allow other investigators to replicate published findings and carry out additional analyses, strengthen the evidence base for regulatory and clinical decisions, and increase the scientific knowledge gained from investments by the funders of clinical trials. The recommendations of Sharing Clinical Trial Data will be useful both now and well into the future as improved sharing of data leads to a stronger evidence base for treatment. This book will be of interest to stakeholders across the spectrum of research-from funders, to researchers, to journals, to physicians, and ultimately, to patients.