Over a third of global agrifood exports cross borders at least twice before reaching the final consumer. The complexity of food supply chains and the growing importance of the global agrifood trade thus creates new and ever greater challenges for the management of food safety. Geographically dispersed foods that have been produced, processed and distributed by multiple actors can pose heightened food safety risks. Tracing the origins of unsafe food is also more complex and time-consuming. For this reason, many nations have implemented more rigorous systems of food control for agrifood imports, while many others need assistance to develop them. To this end, FAO developed this guidance as part of a project entitled 'Digital solutions in support of improved official food control services'. The aim is to provide guidance for the design and implementation of a food control e-notification system, one tailored to national needs and resources. This guidance includes the system’s legal basis, its structure and operational parameters, as well as its infrastructure and human resource requirements.

The Codex Committee on Food Labelling (CCFL) requested scientific advice as to whether certain foods and ingredients, such as highly refined foods and ingredients, that are derived from the list of foods known to cause hypersensitivity can be exempted from mandatory declaration. The objective of this fourth meeting was to expand on the recommendations from the first meeting concerning derivatives of food allergens and establish a framework for evaluating exemptions for food allergens. A pro forma process has been developed and tested against allergen derivatives previously granted exemptions in various countries or regions and found to be effective for consideration in future exemption decisions. The Expert Committee recommends that the process outlined in the pro forma process be used to guide any future development and evaluation of derivative exemptions. Establishment of safety based upon this weight of evidence approach is dependent upon consideration of data quality, outcome of the exposure assessment for all intended ingredient uses (specified for exemption), and review by competent authorities (as needed). When safety is established, exemption can be justified.

Early warning (EW) systems have a critical role in the reduction of risks from various hazards. The capability and capacity to identify early signals and emerging food safety risks, and to provide on-time EW that would allow for the mitigation of related upcoming risks have therefore become vital for national and international authorities and organizations dealing with food safety. The developments in early warning systems show a shift from reactive towards proactive systems. With the rapid development of modern systems fed by numerous, real-time and diverse data, as well as the advancements achieved in artificial intelligence and machine learning techniques, increasingly tested and validated digital methods and models have become available for food safety early warning and analysis. This technical background report enhances the awareness of the available evidence-based innovative digital tools and provides technical background information to support their use for proactive food safety early warning.

Lipid-based nutrient supplements (LNS) and ready-to-use therapeutic food (RUTF) are used to prevent and treat malnutrition in children. [Author] They are often produced in regions experiencing food insecurity and include edible oils obtained from oleaginous seeds or fruits that must be refined to remove undesirable substances and ensure adequate shelf-life for the product. [Author] However, the formation of the heat-induced contaminants 3-monochloropropane-1,2-diol (3-MCPD) fatty acid esters and glycidyl fatty acid esters (GEs) may occur during the refining process of edible oils. [Author] 3-MCPD and its fatty acid esters are present in many other foodstuffs and most of the total lifetime exposure is attributed to foods other than LNS/RUTF. [Author] While the only Codex standard developed for 3-MCPD is for liquid condiments containing acid hydrolyzed vegetable proteins, no Codex standards are available for GEs. [Author] This publication provides an overview of risk assessments for 3-MCPD and GEs previously performed by the Joint FAO/WHO Expert Committee on Food Additives (JECFA), European Food Safety Authority (EFSA) and other authorities, based on chronic exposure. [Author] The use of LNS/RUTF is intended to be of finite duration and confined to a specific life stage. [Author] The aim of this report was to provide an assessment to characterize the risk of less-than-lifetime exposure to 3-MCPD (including 3-MCPD fatty acid esters) and GEs via LNS/RUTF in the context of limited food availability. [Author] The thresholds identified herein for concentrations of 3-MCPD and glycidol equivalents in LNS/RUTF products are considered to represent a level of exposure that is of low concern for human health. [Author]