Synthetic Polymers in Drug and Biotherapeutics Delivery covers new polymers that are fast replacing obsolete polymers in the field of drug delivery. Each chapter focuses on a specific polymer, detailing its design, synthesis, fabrication techniques, and applications in drug and biotherapeutics delivery. Synthetic polymers provide a unique set of opportunities in drug and biotherapeutics delivery due to their chemical versatility and tunable physicochemical properties. Such polymers can be formulated into nanoparticles, nanofibers, nanogels, microparticles, beads, hydrogels, and scaffolds to suit specific needs such as drug release rate, and biodegradation with low toxicity. This book covers new polymers that are fast replacing obsolete polymers in the field of drug delivery. Each chapter will focus on a specific polymer detailing its design, synthesis, fabrication techniques, and applications in drug and biotherapeutics delivery. This book provides a thorough review of the latest research in this rapidly changing field and would be of interest to materials scientists, pharmaceutical scientists, biomedical engineers, chemical engineers, and clinicians with an interest in materials development. - Details the immunological aspects of synthetic polymeric materials, helping the reader prepare for, and even avoid, unwanted side effects of use - Reviews each polymer sub-type, chapter-by-chapter, ensuring thorough coverage and detailed analysis of each - Explores a range of applications in drug and biotherapeutics delivery, including treatments for cardiovascular, neurological and gastrointestinal diseases

Emphasizing four major classes of polymers for drug delivery-water-soluble polymers, hydrogels, biodegradable polymers, and polymer assemblies-this reference surveys efforts to adapt, modify, and tailor polymers for challenging molecules such as poorly water-soluble compounds, peptides/proteins, and plasmid DNA.

Polymers are important and attractive biomaterials for researchers and clinical applications due to the ease of tailoring their chemical, physical and biological properties for target devices. Due to this versatility they are rapidly replacing other classes of biomaterials such as ceramics or metals. As a result, the demand for biomedical polymers has grown exponentially and supports a diverse and highly monetized research community. Currently worth $1.2bn in 2009 (up from $650m in 2000), biomedical polymers are expected to achieve a CAGR of 9.8% until 2015, supporting a current research community of approximately 28,000+. Summarizing the main advances in biopolymer development of the last decades, this work systematically covers both the physical science and biomedical engineering of the multidisciplinary field. Coverage extends across synthesis, characterization, design consideration and biomedical applications. The work supports scientists researching the formulation of novel polymers with desirable physical, chemical, biological, biomechanical and degradation properties for specific targeted biomedical applications. - Combines chemistry, biology and engineering for expert and appropriate integration of design and engineering of polymeric biomaterials - Physical, chemical, biological, biomechanical and degradation properties alongside currently deployed clinical applications of specific biomaterials aids use as single source reference on field. - 15+ case studies provides in-depth analysis of currently used polymeric biomaterials, aiding design considerations for the future

Applications of Polymers in Drug Delivery, Second Edition, provides a comprehensive resource for anyone looking to understand how polymeric materials can be applied to current, new, and emerging drug delivery applications. Polymers play a crucial role in modulating drug delivery and have been fundamental in the successful development of many novel drug delivery systems. This book describes the development of polymeric systems, ranging from conventional dosage forms to the most recent smart systems. Regulatory and intellectual property aspects as well as the clinical applicability of polymeric drug delivery systems are also discussed. The chapters are organized by specific delivery route, offering methodical and detailed coverage throughout. This second edition has been thoroughly revised to include the latest developments in the field. This is an essential book for researchers, scientists, and advanced students, in polymer science, drug delivery, pharmacology/pharmaceuticals, materials science, tissue engineering, nanomedicine, chemistry, and biology. In industry, this book supports scientists, R&D, and other professionals, working on polymers for drug delivery applications. - Explains how polymers can be prepared and utilized for all major drug delivery routes - Presents the latest advances, including drug targeting, polymeric micelles and polymersomes, and the delivery of biologicals and nucleic acid therapeutics - Includes appendices with in-depth information on pharmaceutical properties of polymers and regulatory aspects

Polymeric Nanoparticles as Promising Tool for Anti-cancer Therapeutics provides an understanding of polymeric compounds and their use in cancer therapies. The book begins by giving an overview of the current status, future challenges and potential utilization of polymeric nanoparticles. It then covers specific polymeric nanoparticles through contributions from world-renowned experts and researchers. Chapters examine specific polymeric nanoparticles, their development as potential targeted delivery systems, and cancer characteristics that can be targeted for therapy development. The book synthesizes current research trends in the field, thus enhancing existing knowledge of nanomedicine, drug delivery and therapeutic intervention strategies in human cancers. Users will find this to be an ideal reference for research scientists and those in the pharmaceutical and medical fields who are working to develop novel cancer therapies using nanoparticle-based delivery systems. - Explores the development of polymeric nanoparticle systems for the purpose of cancer therapy - Presents thoroughly analyzed data and results regarding the usage of polymeric nanoparticles-based platforms for the diagnosis and treatment of cancer - Highlights various cancer characteristics that can be targeted for therapeutic development using polymeric nanoparticles

Nanoscience or the science of the very small offers the pharmaceutical scientist a wealth of opportunities. By fabricating at the nanoscale, it is possible to exert unprecedented control on drug activity. This textbook will showcase a variety of nanosystems working from their design and construction to their application in the field of drug delivery. The book is intended for graduate students in drug delivery, physical and polymer chemistry, and applied pharmaceutical sciences courses that involve fundamental nanoscience. The purpose of the text is to present physicochemical and biomedical properties of synthetic polymers with an emphasis on their application in polymer therapeutics i.e., pharmaceutical nanosystems, drug delivery and biological performance. There are two main objectives of this text. The first is to provide advanced graduate students with knowledge of the principles of nanosystems and polymer science including synthesis, structure, and characterization of solution and solid state properties. The second is to describe the fundamentals of therapeutic applications of polymers in drug delivery, targeting, response modifiers as well as regulatory issues. The courses, often listed as Advanced Drug Delivery and Applied Pharmaceutics; Polymer Therapeutics; or Nanomedicine, are designed as an overview of the field specifically for graduate students in the Department of Pharmaceutical Sciences Graduate Programs. However, the course content may also be of interest for graduate students in related biomedical research programs. These courses generally include a discussion of the major principles of polymer science and fundamental concepts of application of polymers as modern therapeutics. All courses are moving away from the above mentioned course names and going by ‘pharmaceutical nanoscience or nanosystems’. This area of research and technology development has attracted tremendous attention during the last two decades and it is expected that it will continue to grow in importance. However, the area is just emerging and courses are limited but they are offered.

"Biomaterials for Advanced Drug and Therapeutic Delivery" provides a detailed review of a range of biomaterials for drug delivery; gene, vaccine and therapeutics delivery, and wound healing and tissue regeneration. Divided into 5 sections, this book begins with an introduction to biomaterials for biomedical applications, before systematically detailing advances in each application. A wide selection of biomaterials are covered, including nanobiomaterials, biopolymers, hydroxyapatite, lipid-based biomaterials, proteins and more; the properties and characteristics of each biomaterial type is assessed, along with it's suitability for a range of drug delivery and therapeutic applications. The final section of the book provides insight into the safety, biocompatibility, preclinical and regulatory aspects of biomaterials use, exploring the translational potential of these novel materials and treatments. "Biomaterials for Advanced Drug and Therapeutic Delivery" is of use to researchers and academics in the fields of materials science, biomaterials, pharmaceutical science, and regenerative medicine with an interest in biomaterials for drug and therapeutics delivery. - Explores the safety, biocompatibility, preclinical and regulatory aspects of biomaterials use for drug delivery and therapeutics - Details a wide range of biomaterial types, from synthetic polymers and biopolymers, to nanobiomaterials and peptide - Utilizes an interdisciplinary approach, bringing together insight from the fields of materials science, pharmaceutical science, and regenerative medicine