Of the thousands of novel compounds that a drug discovery project team invents and that bind to the therapeutic target, typically only a fraction of these have sufficient ADME/Tox properties to become a drug product. Understanding ADME/Tox is critical for all drug researchers, owing to its increasing importance in advancing high quality candidates to clinical studies and the processes of drug discovery. If the properties are weak, the candidate will have a high risk of failure or be less desirable as a drug product. This book is a tool and resource for scientists engaged in, or preparing for, the selection and optimization process. The authors describe how properties affect in vivo pharmacological activity and impact in vitro assays. Individual drug-like properties are discussed from a practical point of view, such as solubility, permeability and metabolic stability, with regard to fundamental understanding, applications of property data in drug discovery and examples of structural modifications that have achieved improved property performance. The authors also review various methods for the screening (high throughput), diagnosis (medium throughput) and in-depth (low throughput) analysis of drug properties. - Serves as an essential working handbook aimed at scientists and students in medicinal chemistry - Provides practical, step-by-step guidance on property fundamentals, effects, structure-property relationships, and structure modification strategies - Discusses improvements in pharmacokinetics from a practical chemist's standpoint

Chemistry and chemical engineering have changed significantly in the last decade. They have broadened their scopeâ€"into biology, nanotechnology, materials science, computation, and advanced methods of process systems engineering and controlâ€"so much that the programs in most chemistry and chemical engineering departments now barely resemble the classical notion of chemistry. Beyond the Molecular Frontier brings together research, discovery, and invention across the entire spectrum of the chemical sciencesâ€"from fundamental, molecular-level chemistry to large-scale chemical processing technology. This reflects the way the field has evolved, the synergy at universities between research and education in chemistry and chemical engineering, and the way chemists and chemical engineers work together in industry. The astonishing developments in science and engineering during the 20th century have made it possible to dream of new goals that might previously have been considered unthinkable. This book identifies the key opportunities and challenges for the chemical sciences, from basic research to societal needs and from terrorism defense to environmental protection, and it looks at the ways in which chemists and chemical engineers can work together to contribute to an improved future.

There is an immense variety of research on polymer functionalized graphene (PFG). Functionalization of graphene is necessary for improvement of the compatibility with polymers. Applications of these graphene polymer hybrids include in chemical and biological sensing, photovoltaic devices, supercapacitors and batteries, dielectric materials and drug/gene delivery vehicles. This book will shed light on the synthesis, properties and applications of these new materials, covering two methods (covalent and noncovalent) for producing polymer functionalized graphene. Chapters cover physical, optical, mechanical and electronic properties, applications of polymer functionalized graphene in energy harvesting and storage, and uses in biomedicine and bioengineering. Written by an expert in the field, Polymer Functionalized Graphene will be of interest to graduate students and researchers in polymer chemistry and nanoscience.

The contributors to this book discuss inorganic synthesis reactions, dealing with inorganic synthesis and preparative chemistry under specific conditions. They go on to describe the synthesis, preparation and assembly of six important categories of compounds with wide coverage of distinct synthetic chemistry systems

Synthesis and Properties of Silicones and Silicone-Modified Materials includes sections on synthesis, characterization, elastomers and reinforcement, surfaces and interfaces, copolymers, and reinforcing fillers. Synthesis and Properties of Silicones and Silicone-Modified Materials reviews recent academic and technological developments behind silicones and silicone-modified materials.

The demand for organosilicon elastomers used in the production of thermally resistant rubbers and organosilicon polymers for making non-metal composite materials is increasing from year to year.This monograph presents a discussion on the methods used for synthesizing and studying properties of newly designed organosilicon polymers, namely organosil