This solid introduction uses the principles of physics and the tools of mathematics to approach fundamental questions of neuroscience.

A comprehensive, multidisciplinary review, Neural Plasticity and Memory: From Genes to Brain Imaging provides an in-depth, up-to-date analysis of the study of the neurobiology of memory. Leading specialists share their scientific experience in the field, covering a wide range of topics where molecular, genetic, behavioral, and brain imaging techniq

Traumatic brain injury (TBI) remains a significant source of death and permanent disability, contributing to nearly one-third of all injury related deaths in the United States and exacting a profound personal and economic toll. Despite the increased resources that have recently been brought to bear to improve our understanding of TBI, the developme

An understanding of the nervous system at virtually any level of analysis requires an understanding of its basic building block, the neuron. From Molecules to Networks provides the solid foundation of the morphologic, biochemical, and biophysical properties of nerve cells. All chapters have been thoroughly revised for this second edition to reflect the significant advances of the past 5 years. The new edition expands on the network aspects of cellular neurobiology by adding a new chapter, Information Processing in Neural Networks, and on the relation of cell biological processes to various neurological diseases. The new concluding chapter illustrates how the great strides in understanding the biochemical and biophysical properties of nerve cells have led to fundamental insights into important aspects of neurodegenerative disease. - Written and edited by leading experts in the field, the second edition completely and comprehensively updates all chapters of this unique textbook - Discusses emerging new understanding of non-classical molecules that affect neuronal signaling - Full colour, professional graphics throughout - Includes two new chapters: Information Processing in Neural Networks - describes the principles of operation of neural networks and the key circuit motifs that are common to many networks in the nervous system. Molecular and Cellular Mechanisms of Neurodegenerative Disease - introduces the progress made in the last 20 years in elucidating the cellular and molecular mechanisms underlying brain disorders, including Amyotrophic Lateral Sclerosis (ALS), Parkinson disease, and Alzheimer's disease

This book reviews current knowledge on the importance of sleep for brain function, from molecular mechanisms to behavioral output, with special emphasis on the question of how sleep and sleep loss ultimately affect cognition and mood. It provides an extensive overview of the latest insights in the role of sleep in regulating gene expression, synaptic plasticity and neurogenesis and how that in turn is linked to learning and memory processes. In addition, readers will learn about the potential clinical implications of insufficient sleep and discover how chronically restricted or disrupted sleep may contribute to age-related cognitive decline and the development of psychiatric disorders such as schizophrenia and depression. The book consists of 19 chapters, written by experts in basic sleep research and sleep medicine, which together cover a wide range of topics on the importance of sleep and consequences of sleep disruption. This book will be of interest to students, researchers and clinicians with a general interest in brain function or a specific interest in sleep.

Written by an award-winning developmental neuroscientist, this is a comprehensive and cutting-edge account of the latest research on the adolescent brain.

This book, a follow-up to the editors' Synaptic Plasticity (MIT Press,1993), reports on the most recent trends in the field. The levels of analysis range from molecular to cellular and network, the unifying theme being the nature of the relationships between synaptic plasticity and information processing and storage. Many neurons exhibit plasticity; that is, they can change structurally or functionally, often in a lasting way. Plasticity is evident in such diverse phenomena as learning and memory, brain development, drug tolerance, sprouting of axon terminals after a brain lesion, and various cellular forms of activity-dependent synaptic plasticity such as long-term potentiation and long-term depression. This book, a follow-up to the editors' Synaptic Plasticity (MIT Press, 1993), reports on the most recent trends in the field. The levels of analysis range from molecular to cellular and network, the unifying theme being the nature of the relationships between synaptic plasticity and information processing and storage. Contributors Yael Amitai, Michel Baudry, Theodore W. Berger, Pierre-Alain Buchs, A.K. Butler, Franck A. Chaillan, Gilbert A. Chauvet, Marie-Françoise Chesselet, Barry W. Connors, Taraneh Ghaffari, Jay R. Gibson, Ziv Gil, Michel Khrestchatisky, Dietmar Kuhl, Carole E. Landisman, Gilles Laurent, Jim-Shih Liaw, David J. Linden, Katrina MacLeod, Henry Markram, W.V. Morehouse, Dominique Muller, J.A. Napieralski, Santiago Rivera, François S. Roman, Bernard Soumireu-Mourat, Oswald Steward, Mark Stopfer, F.G. Szele, Richard F. Thompson, Nicolas Toni, Bernard Truchet, Misha Tsodyks, K. Uryu, Ascher Uziel, Christopher S. Wallace, Yun Wang, Michael Wehr, Paul F. Worley, Xiaping Xie