"This book presents comprehensive accounts of the chemistry revolving around the sulphonamides. Sulfonamides are widely present in various drugs as a functional group and are a manmade synthetic drug. Hence, their extended research is a prerequisite for every practitioner of organic chemistry. Chapter 1 introduces the synthesis, reactivity, acidity, and pharmaceutical properties of the sulphonamides. It highlights the synthesis of biologically active sulphonamides, the study of their biological activity by QSAR method, and their medical applications. Chapter 2 deals with the classification of sulphonamides (i.e. acyclic and cyclic) and their structural activity relationship. It also describes the application of sulphonamides in pharmaceuticals as antimicrobial, anti-diabetic, anti-viral, anti-cancer, anti-inflammatory and anti-malarial agents. Chapter 3 reviews the synthetic attempts towards sulphonamide synthesis by employing the fixation of sulphur-dioxides. These approaches have been categorized into three parts: a) transition metal-catalyzed, b) employing Lewis acid, c) photocatalytic. Chapter 4 discusses the use of sulphonamides as potent organocatalysts, briefly describing how the mono- and C2-symmetric bis-sulfonamides act as efficient bifunctional and multifunctional organocatalysts in the enantioselective Michael addition of carbonyl compounds to alpha, beta-unsaturated compounds. Chapter 5 details the oxidative sulphonamidation of alkenes and dienes, which also direct the routes to the synthesis of numerous heterocycles and linear compounds. Special emphasis is given to the comparison of reactivity of triflamides, arenesulfonamides, and the deprotection of sulfonamides. Chapter 6 describes the therapeutic properties of sulphonamides, which are significantly increased by the presence of the metal ions and ligands. This complex generation provides the opportunity to exploit the unique properties of metal centers, such as multiple oxidation states, redox properties, a wide variety of coordination numbers, symmetries and structural patterns, which offer highly adaptable platforms for drug design. Chapter 7 provides an overview of the clinical applications of sulphonamides on the toxicity and pharmacokinetic aspects of various sulpha-drugs. The mechanism involved in the development of sulfonamide resistance is briefly discussed. Thus, this book summarizes important attempts undertaken by chemists and biologists worldwide in the area of sulphonamides. Most importantly, the book also correlates the structural activity relationship and the related biological activity of the sulphonamides, attracting both novice and experienced chemists across the globe"--

As aquaculture continues to expand there is a need for greater knowledge of medicinal treatments both for the prevention and treatment of disease and for the economic husbandry of fish. This book, the first of its kind, is written for a worldwide readership. It is a reference manual for anyone involved in the selection of medicines for administration to fish. It will also be useful to administrators concerned with the legal control of aquaculture. The first part covers issues which affect all medicine's methods of administering drugs to fish, the various aspects of safety and the relevant legislation in countries with important aquacultural industries. Subsequent parts review the range of available medicinal substances and present current knowledge of the pharmacology and methods of use for each. Particular attention is given to safety issues - for the fish, for the person administering the medicine, for the consumer of medicated fish and for the environment.

Written by the foremost authority in the field, this volume is a comprehensive review of the multifaceted phenomenon of hepatotoxicity. Dr. Zimmerman examines the interface between chemicals and the liver; the latest research in experimental hepatotoxicology; the hepatotoxic risks of household, industrial, and environmental chemicals; and the adverse effects of drugs on the liver. This thoroughly revised, updated Second Edition features a greatly expanded section on the wide variety of drugs that can cause liver injury. For quick reference, an appendix lists these medications and their associated hepatic injuries. Also included are in-depth discussions of drug metabolism and factors affecting susceptibility to liver injury.

Drug-Induced Liver Injury, Volume 85, the newest volume in the Advances in Pharmacology series, presents a variety of chapters from the best authors in the field. Chapters in this new release include Cell death mechanisms in DILI, Mitochondria in DILI, Primary hepatocytes and their cultures for the testing of drug-induced liver injury, MetaHeps an alternate approach to identify IDILI, Autophagy and DILI, Biomarkers and DILI, Regeneration and DILI, Drug-induced liver injury in obesity and nonalcoholic fatty liver disease, Mechanisms of Idiosyncratic Drug-Induced Liver Injury, the Evaluation and Treatment of Acetaminophen Toxicity, and much more. - Includes the authority and expertise of leading contributors in pharmacology - Presents the latest release in the Advances in Pharmacology series

AN AUTHORITATIVE SURVEY OF CURRENT RESEARCH INTO CLINICALLY USEFUL CONVENTIONAL AND NONCONVENTIONAL ANTIBIOTIC THERAPEUTICS Pharmaceutically-active antibiotics revolutionized the treatment of infectious diseases, leading to decreased mortality and increased life expectancy. However, recent years have seen an alarming rise in the number and frequency of antibiotic-resistant "Superbugs." The Centers for Disease Control and Prevention (CDC) estimates that over two million antibiotic-resistant infections occur in the United States annually, resulting in approximately 23,000 deaths. Despite the danger to public health, a minimal number of new antibiotic drugs are currently in development or in clinical trials by major pharmaceutical companies. To prevent reverting back to the pre-antibiotic era—when diseases caused by parasites or infections were virtually untreatable and frequently resulted in death—new and innovative approaches are needed to combat the increasing resistance of pathogenic bacteria to antibiotics. Bacterial Resistance to Antibiotics – From Molecules to Man examines the current state and future direction of research into developing clinically-useful next-generation novel antibiotics. An internationally-recognized team of experts cover topics including glycopeptide antibiotic resistance, anti-tuberculosis agents, anti-virulence therapies, tetracyclines, the molecular and structural determinants of resistance, and more. Presents a multidisciplinary approach for the optimization of novel antibiotics for maximum potency, minimal toxicity, and appropriated degradability Highlights critical aspects that may relieve the problematic medical situation of antibiotic resistance Includes an overview of the genetic and molecular mechanisms of antibiotic resistance Addresses contemporary issues of global public health and longevity Includes full references, author remarks, and color illustrations, graphs, and charts Bacterial Resistance to Antibiotics – From Molecules to Man is a valuable source of up-to-date information for medical practitioners, researchers, academics, and professionals in public health, pharmaceuticals, microbiology, and related fields.

The is the third edition of a text that surveys the drugs used to treat bacterial, fungal, prarsitic, and viral infections. This book contains comprehensive presentations of the mechanisms for both the antimicrobial actions and for the adverse clinical effects of these drugs. Complete discussions of the pharmacology are highlighted by numerous charts and tables summarizing each drug's pharmacokinetic properties and microbial susceptibility. With 3500 reference citations, The Anitmicrobial Drugs provides a complete entry into the literature, making it an invaluable resource for infectious disease specialists, clinical pharmacists, clinical microbiologists, medical students, pharmacy students, and graduate students in pharmacology and microbiology.