This book is designed to collect and review the research covering main directions in investigations of aromatic nitroso compounds in last decades, and to present both, the academic aspects of this chemistry, as well as the open field of its applicability. The book is divided in five chapters. The basic structural properties of the nitroso aromatic molecules are described in the first chapter. The second chapter is an overview of the methods of preparations of aromatic nitroso and polynitroso compounds, including classical synthetic methods and some new preparative approaches. The third part deals with the physico-chemical properties of nitroso aromates and azodioxides, its structure, crystallography, quantum chemical calculations, spectroscopy, typical reactions, and especially it is focused on the dimerizations in the solid-state. In the fourth chapter is represented organometallic chemistry of nitroso aromatic molecules and its applications in catalysis. The last part of the book deals with the behavior of this class of compounds in the biological systems, reactions with biomolecules and the use in toxicology.

This book collects and reviews research covering aromatic nitroso compounds, presenting both academic aspects and the open field of its applicability. Covers basic structural properties, methods of preparation, reactions with biomolecules and more.

The study of natural and synthetic organic compounds has been investigated. The use of one-dimensional and two-dimensional NMR methods as a method for rapidly assigning structures was demonstrated. Structural elucidation was performed on unknown side-products in synthetic sequences to conclusively determine what reactions had taken place. Steps toward a biomimetic synthesis of the alkaloid, dihydrocadambine, were carried out. The isolation of the natural product precursor to this alkaloid, secologanin, was first performed. In the course of isolating secologanin, two other natural products, loganin and sweroside were also isolated and structurally elucidated. The intermediates in the attempted synthesis of dihydrocadambine were also examined. Finally, NMR methods were applied to characterization of diterpene and sesquiterpene natural products isolated in the Caribbean. Eleven of the natural products investigated were determined to be novel.

Although numerical data are, in principle, universal, the compilations presented in this book are extensively annotated and interleaved with text. This translation of the second German edition has been prepared to facilitate the use of this work, with all its valuable detail, by the large community of English-speaking scientists. Translation has also provided an opportunity to correct and revise the text, and to update the nomenclature. Fortunately, spectroscopic data and their relationship with structure do not change much with time so one can predict that this book will, for a long period of time, continue to be very useful to organic chemists involved in the identification of organic compounds or the elucidation of their structure. Klaus Biemann Cambridge, MA, April 1983 Preface to the First German Edition Making use of the information provided by various spectroscopic tech niques has become a matter of routine for the analytically oriented organic chemist. Those who have graduated recently received extensive training in these techniques as part of the curriculum while their older colleagues learned to use these methods by necessity. One can, therefore, assume that chemists are well versed in the proper choice of the methods suitable for the solution of a particular problem and to translate the experimental data into structural information.