A comprehensive introduction to a wide variety of statistical methods for the analysis of repeated measurements. It is designed to be both a useful reference for practitioners and a textbook for a graduate-level course focused on methods for the analysis of repeated measurements. The important features of this book include a comprehensive coverage of classical and recent methods for continuous and categorical outcome variables; numerous homework problems at the end of each chapter; and the extensive use of real data sets in examples and homework problems.

Repeated measures data arise when the same characteristic is measured on each case or subject at several times or under several conditions. There is a multitude of techniques available for analysing such data and in the past this has led to some confusion. This book describes the whole spectrum of approaches, beginning with very simple and crude methods, working through intermediate techniques commonly used by consultant statisticians, and concluding with more recent and advanced methods. Those covered include multiple testing, response feature analysis, univariate analysis of variance approaches, multivariate analysis of variance approaches, regression models, two-stage line models, approaches to categorical data and techniques for analysing crossover designs. The theory is illustrated with examples, using real data brought to the authors during their work as statistical consultants.

Integrates the latest theory, methodology and applications related to the design and analysis of repeated measurement. The text covers a broad range of topics, including the analysis of repeated measures design, general crossover designs, and linear and nonlinear regression models. It also contains a 3.5 IBM compatible disk, with software to implement immediately the techniques.

Here is an essential introduction to the latest arsenal of methods available to students and practicing scientists who undertake longitudinal and other studies that collect repeated measurements for subsequent analysis. The book presents the general context of repeated measurements and introduces--through a large number of concrete examples, including data tables--the three basic types of response variables: continuous (normal), categorical and count, and duration variables. The ways in which such repeated observations are interdependent, through heterogeneity and time dependence, are discussed. The author also develops a useful framework for constructing suitable models and introduces concepts of multivariate distributions and stochastic processes necessary to appreciate the underpinnings and power of repeated measurements analyses. The book concludes with an extensive bibliography of the repeated measurement literature that will aid readers interested in finding source materials. Written by a distinguished statistician, this book is a much-needed and practical guide to the most current repeated measurements techniques available. It will be welcomed by students, applied statisticians, biostatisticians, biologists, medical researchers, econometricians, sociologists, and psychologists.

This book presents a broad range of statistical techniques to address emerging needs in the field of repeated measures. It also provides a comprehensive overview of extensions of generalized linear models for the bivariate exponential family of distributions, which represent a new development in analysing repeated measures data. The demand for statistical models for correlated outcomes has grown rapidly recently, mainly due to presence of two types of underlying associations: associations between outcomes, and associations between explanatory variables and outcomes. The book systematically addresses key problems arising in the modelling of repeated measures data, bearing in mind those factors that play a major role in estimating the underlying relationships between covariates and outcome variables for correlated outcome data. In addition, it presents new approaches to addressing current challenges in the field of repeated measures and models based on conditional and joint probabilities. Markov models of first and higher orders are used for conditional models in addition to conditional probabilities as a function of covariates. Similarly, joint models are developed using both marginal-conditional probabilities as well as joint probabilities as a function of covariates. In addition to generalized linear models for bivariate outcomes, it highlights extended semi-parametric models for continuous failure time data and their applications in order to include models for a broader range of outcome variables that researchers encounter in various fields. The book further discusses the problem of analysing repeated measures data for failure time in the competing risk framework, which is now taking on an increasingly important role in the field of survival analysis, reliability and actuarial science. Details on how to perform the analyses are included in each chapter and supplemented with newly developed R packages and functions along with SAS codes and macro/IML. It is a valuable resource for researchers, graduate students and other users of statistical techniques for analysing repeated measures data.