A comprehensive introduction to modern applied statistical genetic data analysis, accessible to those without a background in molecular biology or genetics. Human genetic research is now relevant beyond biology, epidemiology, and the medical sciences, with applications in such fields as psychology, psychiatry, statistics, demography, sociology, and economics. With advances in computing power, the availability of data, and new techniques, it is now possible to integrate large-scale molecular genetic information into research across a broad range of topics. This book offers the first comprehensive introduction to modern applied statistical genetic data analysis that covers theory, data preparation, and analysis of molecular genetic data, with hands-on computer exercises. It is accessible to students and researchers in any empirically oriented medical, biological, or social science discipline; a background in molecular biology or genetics is not required. The book first provides foundations for statistical genetic data analysis, including a survey of fundamental concepts, primers on statistics and human evolution, and an introduction to polygenic scores. It then covers the practicalities of working with genetic data, discussing such topics as analytical challenges and data management. Finally, the book presents applications and advanced topics, including polygenic score and gene-environment interaction applications, Mendelian Randomization and instrumental variables, and ethical issues. The software and data used in the book are freely available and can be found on the book's website.

Statistical modeling is a critical tool in scientific research. This book provides comprehensive explanations of the concepts and philosophy of statistical modeling, together with a wide range of practical and numerical examples. The authors expect this work to be of great value not just to statisticians but also to researchers and practitioners in various fields of research such as information science, computer science, engineering, bioinformatics, economics, marketing and environmental science. It’s a crucial area of study, as statistical models are used to understand phenomena with uncertainty and to determine the structure of complex systems. They’re also used to control such systems, as well as to make reliable predictions in various natural and social science fields.

This book is a guide to the practical application of statistics in data analysis as typically encountered in the physical sciences. It is primarily addressed at students and professionals who need to draw quantitative conclusions from experimental data. Although most of the examples are takenfrom particle physics, the material is presented in a sufficiently general way as to be useful to people from most branches of the physical sciences. The first part of the book describes the basic tools of data analysis: concepts of probability and random variables, Monte Carlo techniques,statistical tests, and methods of parameter estimation. The last three chapters are somewhat more specialized than those preceding, covering interval estimation, characteristic functions, and the problem of correcting distributions for the effects of measurement errors (unfolding).

This is the first comprehensive, yet clearly presented, account of statistical methods for analysing spherical data. The analysis of data, in the form of directions in space or of positions of points on a spherical surface, is required in many contexts in the earth sciences, astrophysics and other fields, yet the methodology required is disseminated throughout the literature. Statistical Analysis of Spherical Data aims to present a unified and up-to-date account of these methods for practical use. The emphasis is on applications rather than theory, with the statistical methods being illustrated throughout the book by data examples.

This broad text provides a complete overview of most standard statistical methods, including multiple regression, analysis of variance, experimental design, and sampling techniques. Assuming a background of only two years of high school algebra, this book teaches intelligent data analysis and covers the principles of good data collection. * Provides a complete discussion of analysis of data including estimation, diagnostics, and remedial actions * Examples contain graphical illustration for ease of interpretation * Intended for use with almost any statistical software * Examples are worked to a logical conclusion, including interpretation of results * A complete Instructor's Manual is available to adopters

The Minimum Message Length (MML) Principle is an information-theoretic approach to induction, hypothesis testing, model selection, and statistical inference. MML, which provides a formal specification for the implementation of Occam's Razor, asserts that the ‘best’ explanation of observed data is the shortest. Further, an explanation is acceptable (i.e. the induction is justified) only if the explanation is shorter than the original data. This book gives a sound introduction to the Minimum Message Length Principle and its applications, provides the theoretical arguments for the adoption of the principle, and shows the development of certain approximations that assist its practical application. MML appears also to provide both a normative and a descriptive basis for inductive reasoning generally, and scientific induction in particular. The book describes this basis and aims to show its relevance to the Philosophy of Science. Statistical and Inductive Inference by Minimum Message Length will be of special interest to graduate students and researchers in Machine Learning and Data Mining, scientists and analysts in various disciplines wishing to make use of computer techniques for hypothesis discovery, statisticians and econometricians interested in the underlying theory of their discipline, and persons interested in the Philosophy of Science. The book could also be used in a graduate-level course in Machine Learning and Estimation and Model-selection, Econometrics and Data Mining. C.S. Wallace was appointed Foundation Chair of Computer Science at Monash University in 1968, at the age of 35, where he worked until his death in 2004. He received an ACM Fellowship in 1995, and was appointed Professor Emeritus in 1996. Professor Wallace made numerous significant contributions to diverse areas of Computer Science, such as Computer Architecture, Simulation and Machine Learning. His final research focused primarily on the Minimum Message Length Principle.

This book reconsiders statistical methods from the point of view of entropy, and introduces entropy-based approaches for data analysis. Further, it interprets basic statistical methods, such as the chi-square statistic, t-statistic, F-statistic and the maximum likelihood estimation in the context of entropy. In terms of categorical data analysis, the book discusses the entropy correlation coefficient (ECC) and the entropy coefficient of determination (ECD) for measuring association and/or predictive powers in association models, and generalized linear models (GLMs). Through association and GLM frameworks, it also describes ECC and ECD in correlation and regression analyses for continuous random variables. In multivariate statistical analysis, canonical correlation analysis, T2-statistic, and discriminant analysis are discussed in terms of entropy. Moreover, the book explores the efficiency of test procedures in statistical tests of hypotheses using entropy. Lastly, it presents an entropy-based path analysis for structural GLMs, which is applied in factor analysis and latent structure models. Entropy is an important concept for dealing with the uncertainty of systems of random variables and can be applied in statistical methodologies. This book motivates readers, especially young researchers, to address the challenge of new approaches to statistical data analysis and behavior-metric studies.