This book provides an overview of statin-associated muscle symptoms (SAMS) from clinical presentation to treatment and possible metabolic causes. It examines the risk factors, presentations, diagnosis and differential diagnosis, clinical management, and financial costs of SAMS. The book also highlights patients’ perspectives on SAMS such as the psychosocial, emotional, and societal factors influencing their perceptions and experiences. Finally, the book presents the results of observational and clinical trials on the prevalence of SAMS, clinical trials for treatments, and potential future research approaches for improving the understanding and treatment of SAMS. A key addition to the Contemporary Cardiology series, Statin-Associated Muscle Symptoms is an essential resource for physicians, medical students, residents, fellows, and allied health professionals in cardiology, endocrinology, pharmacotherapy, primary care, and health promotion and disease prevention.

The Essential Guide to Recognizing and Treating Acute Endocrine and Metabolic Illness Endocrinology covers some of the most common conditions and serious public health challenges facing medicine today, and endocrine and metabolic emergencies constitute a large proportion of the clinical workload. Endocrine and Metabolic Medical Emergencies: A Clinician’s Guide provides a singular reference to help endocrinologists, acute and general medicine clinicians, hospitalists and critical care physicians, and general practitioners recognize the symptoms of endocrine emergencies and provide the highest standards of care. Already the definitive and most comprehensive guide to endocrine emergency care, this new second edition: provides acute care guidance for a range of both common and unusual endocrine emergencies; details the effects of acute medical and critical illness on metabolic and endocrine systems, and their impacts on endocrine investigations; discusses special patient populations, including the impacts of aging, pregnancy, transplantation, late-effects, perioperative, inherited metabolic disorders and HIV/AIDS on presentation and management; and features detailed coverage of disorders by system, as well as, metabolic bone diseases, neuroendocrine tumors, and more. Packed with case studies, images, and chapters written by distinguished authors, this guide is designed for both quick reference and study. Coverage includes the presentation, diagnosis, management, and treatment of endocrine and metabolic disorders in an acute care setting, as well as the most up-to-date guidance on issues including clinical lipidology, glucose, sodium, calcium and phosphate, and more. Blending the latest science with clinical and practical advice, this invaluable resource helps clinicians stay up to date with the field’s relevant body of knowledge while providing the practical, clinical insight they need in order to provide their patients with the utmost level of care.

Rewritten and redesigned, this remains the one essential text on the diseases of skeletal muscle.

Statin-associated muscle symptoms (SAMS) are one of the main reasons for statin non-adherence and/or discontinuation.The PROSISA is an observational, retrospective and multicenter study aimed at assessing the prevalence of statin intolerance, due to muscolar symptoms, in dyslipidemic patients on statins followed by Italian lipid clinics. Anamnestic data, biochemical values, and potential occurence of muscular symptoms were collected. Adjusted logistic regression was fitted to estimate odds ratio (OR) and 95% confidence intervals for the association between SAMS onset and several factors.In the first six months of activity, the PROSISA database accounted for 6429 patients (mean age 66.7u00b112 years; 53.9% males) on statins. During statin therapy, 787 patients (12.2%) reported muscular symptoms (63,9% within the first year of treatment): myalgia (74.2%) and cramps (25.8%), mainly. Among them, 375 patients underwent dechallenge, with disappearance of muscular symptoms in 87.2% of cases, while overall 503 patients underwent rechallenge (237 with change of statin/dose reduction without interruption of therapy) mainly with low-intensity statins, with reappearance of muscular symptoms (myalgia 76.2%) in only 151 patients. Risk of SAMS onset was significantly higher for patients with diabetes (OR 1.58 [1.26-1.98]), using high potency statins (OR 1.32 [1.09-1.59]) and with an interacting drugs therapy (OR 1.65 [1.14-2.39]).This analysis offers a real life outlook of SAMS. The percentage of patients in whom intolerance has been confirmed by dechallenge/rechallenge is between 26-30%, emphasizing the need to deepen the assessment beyond the simple occurrence of muscle symptoms for definitive diagnosis of SAMS and if needed treatment re-evaluation.

'The Oxford Textbook of Neuromuscular Disorders' covers the scientific basis, clinical diagnosis, and treatment of neuromuscular disorders, with a particular focus on the most clinically relevant disorders

A Video Atlas of Neuromuscular Disorders is the essential reference on adult neuromuscular disorders and their diagnosis and treatment. Perfect for preparing for the neurology and neuromuscular boards, this book and accompanying videos have become an invaluable resource for neurology and neuromuscular training programs, while catering to the too-busy and often-overwhelmed modern doctor with its straightforward structure and language.

Oxidative Stress and Antioxidant Protection: The Science of Free Radical Biology and Disease Oxidative Stress and Antioxidant Protection begins with a historical perspective of pioneers in oxidative stress with an introductory section that explains the basic principles related to oxidative stress in biochemistry and molecular biology, demonstrating both pathways and biomarkers. This section also covers diagnostic imaging and differential diagnostics. The following section covers psychological, physiologic, pharmacologic and pathologic correlates. This section addresses inheritance, gender, nutrition, obesity, family history, behavior modification, natural herbal-botanical products, and supplementation in the treatment of disease. Clinical trials are also summarized for major medical disorders and efficacy of treatment, with particular focus on inflammation, immune response, recycling, disease progression, outcomes and interventions. Each of the chapters describes what biomarker(s) and physiological functions may be relevant to a concept of specific disease and potential alternative therapy. The chapters cover medical terminology, developmental change, effects of aging, senescence, lifespan, and wound healing, and also illustrates cross-over exposure to other fields. The final chapter covers how and when to interpret appropriate data used in entry level biostatistics and epidemiology. Authored and edited by leaders in the field, Oxidative Stress and Antioxidant Protection will be an invaluable resource for students and researchers studying cell biology, molecular biology, and biochemistry, as well professionals in various health science fields.