Starbase 99 has been compromised. Worf and the Defiant crew are quarantined within, desperately trying to evade the infected as their parasitic counterparts flood the floors of the base. To make matters worse, one of the crew’s bounties is dead, another missing. Can the crew survive this raging parasitic invasion on the desolate starbase?

Miles O’Brien and his trusty holo-helm set course for the planet Antara as Romulan forces prepare to besiege the population with Worf, B’Elanna, and Ro among them. A menacing Romulan blockade stands between him and his friends, but as he braces to brave the Romulans alone, matters are further complicated when an old friend—none other than Dr. Julian Bashir—delivers an urgent message from Section 31. Meanwhile, on Romulus, Commander Sela and Spock uncover a dark secret that General Revo is willing to kill to keep secret…

Arc three of the acclaimed Star Trek ongoing series starts here! Captain Benjamin Sisko’s quest to defeat the killer of gods is at an end, and the Prophets beckon him home to the Celestial Temple. He’s earned his rest, but when Starfleet requests his help to stop a familiar foe, the Tzenkethi Coalition, from launching the largest fleet in their history, Sisko and the Theseus’ crew set out to once again save the galaxy. But there’s a reason this species of spiritually rich, reptilian lizard birds has twice defeated Starfleet in battle. They’re xenophobic, ruthless, and innovative...and confronting them on their home turf, a planet thought to be an organism itself, is as good a death sentence as any.

The Defiant crew makes way for its next bounty: Berlinghoff Rasmussen, infamous time-traveling thief and con man. Berlinghoff has escaped custody on Starbase 214 and has his sights set on tech from the forbidden planet and final resting place of Captain Christopher Pike, Talos IV. With top-secret orders from Starfleet, Worf and his crew are to intercept the target without being detected by anyone…including the Federation.

It’s a good day to die! Left with no other choice, the crew of the Defiant assists Hugh in assimilating B’Elanna in hopes of reclaiming control over the parasite embedded in her brain stem. But it’s a race against time and the undead as hordes of infected Starbase crew bang on the hangar doors, demanding Worf and his crew surrender and become one with the parasitic collective!

Amid a ruse gone wrong, Worf and his away team of B’Elanna Torres and Ro Laren find themselves imprisoned by Orion pirates wary of the supposed Maquis separatists. Meanwhile, in the captain’s chair of the Defiant, Spock struggles to defend the ship with Lore’s musings of chaos in his ear.

Spinning directly out of the Star Trek ongoing comic series, Defiant adds to this bold new storytelling future! Someone is killing the gods. But Benjamin Sisko’s Prophets-guided dealings of the higher cosmos has led him to forget about the very real casualties on lower ground. But who is this new enemy? Worf of House Martok has put together his own crew aboard the U.S.S. Defiant in hopes of defeating the dangerous messiah behind this genocidal cult. The Dirty Dozen meets Star Trek in this new series from the creative minds of Chris Cantwell (Iron Man, Namor, Star Wars: Obi-Wan) and Angel Unzueta (Iron Man, Star Wars: Poe Dameron, The Flash)! An exciting stand-alone story, Star Trek: Defiant can also be read along with the events of Star Trek, Vol. 1: Godshock for the complete experience!