Collects Sinister War (2021) #1-4. Doctor Octopus is back! He's assembled a new Sinister Six - and if you think he's thought big in the past, think again. But what Doc Ock doesn't know is that the Vulture has a sextet of his own: the Savage Six! Brace yourself for all-out war between two of the greatest villains in the Marvel Universe - and the only person they hate more than each other is Spider-Man! Spidey's in deep trouble with the toughest battle he's ever faced and a deadly dozen of his fiercest foes out for blood! AMAZING SPIDER-MAN scribe Nick Spencer and the legendary Artist Mark Bagley team up for an epic story guaranteed to shock readers!

Collects Amazing Spider-Man (2018) #66-69, Giant-Size Amazing Spider-Man: Chameleon Conspiracy (2021) #1. One of Spider-Man's deadliest and most deceptive enemies returns! The master of disguise known as the Chameleon is about to make the biggest play of his villainous career - and to get to the bottom of this conspiracy, Spidey will need to team up with his super-spy sister, Teresa! But with two sets of Parker luck working against them, will they stand a chance against the anarchic alliance the Chameleon has formed with the Foreigner, Chance and Jack O' Lantern? Prepare for an unpredictable, revelatory tale that fans of the web-slinger dare not miss as Nick Spencer's high-octane saga takes its next dramatic twist!

Collects Amazing Spider-Man (2018) #70-74. Nick Spencer's Spider-Man saga reaches new heights! The Sinister War between Doctor Octopus and the Vulture is about to turn Spider-Man's life upside down! And the fact that "King's Ransom" and "Chameleon Conspiracy" already did that twice over might give you an idea of just how hard this latest crisis is going to be for the wall-crawler! But as two of the deadliest teams of villains ever to exist go to all-out war with both Spidey and each other, what is Kindred's role in the chaos - and what is his horrific endgame? There's simply no way of describing how intense and impossible this situation is for Peter Parker!

Collects Amazing Spider-Man Annual #1 Amazing Spider-Man #334-339. When still in high school, the Amazing Spider-Man faced one of his most chilling challenges when six of his most nerve-wracking nemeses formed the Sinister Six! Years later, Doctor Octopus reunites the team for his most remarkable racket yet, and time has made them deadlier than ever!

Celebrating 50 years of power and responsibility! The most powerful entity on Earth is Alpha - a brash Midtown High slacker who gained his powers in a lab accident during an experiment conducted by none other than Peter Parker! To head off worldwide calamity, he'll have to learn how to be a hero - and fast! And that means Spider-Man's got his first-ever sidekick! Then: war of the Hobgoblins! Phil Urich has donned the demonic cowl as the Kingpin's top enforcer, but Roderick Kingsley is back, seeking to reclaim his murderous mantle. And Kingsley may not be the only former Goblin who wants to stake his claim! Plus: Peter struggles to tell Aunt May the secret he's hidden for years: He's responsible for his uncle's death! COLLECTING: Amazing Spider-Man 692-697, Avenging Spider-Man 11

Collects Amazing Spider-Man (2018) #16-23, #16.HH and #18.HU-20.HU. VOLUME 4 of Nick Spencer's AMAZING SPIDER-MAN run! When Kraven returns, Spider-Man becomes the hunted! Sergei Kravinoff and his minions have been kidnapping animal-themed superhumans for months, and they need one more to complete the collection: the Spider. But what does Kraven want with all of them?! In Central Park, the prey is let loose, and the hunt begins - but Kraven isn't the one in pursuit. Who has Spidey in their crosshairs? The Lizard has a target on his back, too - but he has a truly terrifying plan of his own! Peter Parker will find himself in a horrible situation, but there are lives - innocent and otherwise - at stake, and...well...he's Spider-Man. When it comes to the big showdown, you have no idea how this one will go down!

Collects Eternals (2021) #1-6. Never die…never win. What's the point of an eternal battle? For millions of years, one hundred Eternals have roamed the Earth, secret protectors of humanity. Without them, mankind would be smears between the teeth of the demon-like Deviants. Their war has waged for all time, echoing in our myths and nightmares. But today, the Eternals face something new: change! Can they - or anyone on Earth - survive their discovery? An Eternal has been murdered by one of their own, and this may not be the last such killing. But Sersi's number one suspect is…Thena?! Plus: Titans clash in a city driven mad as Ikaris battles Thanos! From the thought-provoking minds of Kieron Gillen (YOUNG AVENGERS, UNCANNY X-MEN) and Esad Ribić (THOR: GOD OF THUNDER, SECRET WARS) comes a new vision of the classic Marvel mythology!