Serotonin and Gastrointestinal Function provides a comprehensive review of current research into the mechanisms by which serotonin acts on gastrointestinal tissues. This book covers neurochemistry, physiology, pharmacology, and clinical issues relevant to serotonin in the gastrointestinal tract. The editors have brought together the most relevant information from the molecular to the clinical level. Each chapter is written by investigators experienced in research on serotonin's actions in the gut. This book will be useful to basic scientists, clinical investigators, graduate and postgraduate students.

The Complex Interplay Between Gut–Brain, Gut–Liver, and Liver–Brain Axes provides current and wide-ranging information in the field of gastrointestinal, liver, and brain interactions that can be used in resolving important clinical issues. This book is systematically split into three distinct sections. The first section introduces the pathophysiology of the gut–brain connection, including the causative effect of the interactions between the gut and brain in gastrointestinal and psychiatric/neurological disorders, and the role of serotonin and its pathways in gastrointestinal disorders. The second section examines the pathophysiology of the gut–liver connection along with the interactions between gut microbiota and liver in chronic liver diseases, with special focus on the role of serotonin and its pathways in hepatic fibrogenesis. Finally, the third section describes the pathophysiology of the liver–brain connection, including the role of gut microbiota in hepatic encephalopathy, as well as dietary and therapeutic interventions that target the gut microbiome. - Provides current and wide-ranging knowledge in the field of gastrointestinal, liver, and brain interactions - Resolves important clinical issues concerning gut, liver, and brain interactions - Demonstrates advances in the understanding of the pathophysiology of gastrointestinal and liver diseases

Serotonin and Gastrointestinal Function provides a comprehensive review of current research into the mechanisms by which serotonin acts on gastrointestinal tissues. This book covers neurochemistry, physiology, pharmacology, and clinical issues relevant to serotonin in the gastrointestinal tract. The editors have brought together the most relevant information from the molecular to the clinical level. Each chapter is written by investigators experienced in research on serotonin's actions in the gut. This book will be useful to basic scientists, clinical investigators, graduate and postgraduate students.

This book explains the pharmacological relationships between the various systems in the human body. It offers a comprehensive overview of the pharmacology concerning the autonomic, central, and peripheral nervous systems. Presenting up-to-date information on chemical mediators and their significance, it highlights the therapeutic aspects of several diseases affecting the cardiovascular, renal, respiratory, gastrointestinal, endocrinal, and hematopoietic systems. The book also includes drug therapy for microbial and neoplastic diseases. It also comprises sections on immunopharmacology, dermatological, and ocular pharmacology providing valuable insights into these emerging and recent topics. Covering the diverse groups of drugs acting on different systems, the book reviews their actions, clinical uses, adverse effects, interactions, and subcellular mechanisms of action. It is divided into 11 parts, subdivided into several chapters that evaluate the basic pharmacological principles that govern the different types of body systems. This book is intended for academicians, researchers, and clinicians in industry and academic institutions in pharmaceutical, pharmacological sciences, pharmacy, medical sciences, physiology, neurosciences, biochemistry, molecular biology and other allied health sciences.

Written by the foremost authority in the field, this volume is a comprehensive review of the multifaceted phenomenon of hepatotoxicity. Dr. Zimmerman examines the interface between chemicals and the liver; the latest research in experimental hepatotoxicology; the hepatotoxic risks of household, industrial, and environmental chemicals; and the adverse effects of drugs on the liver. This thoroughly revised, updated Second Edition features a greatly expanded section on the wide variety of drugs that can cause liver injury. For quick reference, an appendix lists these medications and their associated hepatic injuries. Also included are in-depth discussions of drug metabolism and factors affecting susceptibility to liver injury.

“Persuasive, impassioned. . . hopeful news [for those] suffering from functional bowel disease.” — New York Times Book Review Dr. Michael Gershon’s groundbreaking book fills the gap between what you need to know—and what your doctor has time to tell you. Dr. Michael Gershon has devoted his career to understanding the human bowel (the stomach, esophagus, small intestine, and colon). His thirty years of research have led to an extraordinary rediscovery: nerve cells in the gut that act as a brain. This "second brain" can control our gut all by itself. Our two brains—the one in our head and the one in our bowel—must cooperate. If they do not, then there is chaos in the gut and misery in the head—everything from "butterflies" to cramps, from diarrhea to constipation. Dr. Gershon's work has led to radical new understandings about a wide range of gastrointestinal problems including gastroenteritis, nervous stomach, and irritable bowel syndrome. The Second Brain represents a quantum leap in medical knowledge and is already benefiting patients whose symptoms were previously dismissed as neurotic or "it's all in your head."