This thesis describes in detail the search for new phenomena in mono-jet final states with the ATLAS experiment at the LHC. The final state is considered the golden channel in the searches for large extra dimensions (LED) but also allows access to a very rich SUSY-related phenomenology pertaining to the production of weakly interacting massive particles (WIMPS), SUSY Dark Matter candidates, GMSB SUSY models with very light gravitino masses, as well as stop an sbottom pair production in compressed scenarios (with nearly degenerated squarks and the lightest neutralino), and also invisible Higgs searches, among others. Here, a number of these scenarios are explored. The measurements presented yield new powerful constraints on the existence of extra spatial dimensions, the pair production of WIMPs, and also provide the best limit to date on the gravitino mass.

This PhD thesis documents two of the highest-profile searches for supersymmetry performed at the ATLAS experiment using up to 80/fb of proton-proton collision data at a center-of-mass energy of 13 TeV delivered by the Large Hadron Collider (LHC) during its Run 2 (2015-2018). The signals of interest feature a high multiplicity of jets originating from the hadronisation of b-quarks and large missing transverse momentum, which constitutes one of the most promising final state signatures for discovery of new phenomena at the LHC. The first search is focused on the strong production of a pair of gluinos, with each gluino decaying into a neutralino and a top-antitop-quark pair or a bottom-antibottom-quark pair. The second search targets the pair production of higgsinos, with each higgsino decaying into a gravitino and a Higgs boson, which in turn is required to decay into a bottom-antibottom-quark pair. Both searches employ state-of-the-art experimental techniques and analysis strategies at the LHC, resulting in some of the most restrictive bounds available to date on the masses of the gluino,neutralino, and higgsino in the context of the models explored.