Scientific Advances in Reconstructive Urology and Tissue Engineering is a comprehensive overview of reconstructive urology that spans male and female, pediatric, neuro-urology and trauma. Traditionally, this field has been focused solely on surgical principles with little attention to basic and translational research. However, recent advances in acellular matrices, scaffolds, stem cells and tissue engineering have changed this focus. This publication is the perfect bridge and definitive tome of the advances that will move the translational and basic science of reconstructive urology forward and allow readers to implement the findings in clinical practice. Through the use of both current case studies and future implications, the content bridges the gap from bench to bedside making it the perfect reference for translational benign urology researchers who wish to move the field of reconstructive surgery forward. Includes real-world applications of current research to help readers get rapidly up-to-speed on which research results are appropriate for immediate implementation Presents the underlying mechanism of urologic disease processes pertinent to reconstructive urology for comprehensive understanding within the field Provides independent guidance to manage specific clinical conditions while also presenting approaches that are applicable to all conditions

Since the publication of the first edition of Urethral Reconstructive Surgery, important refinements have been added to the urologic surgical armamentarium. Extensively revised and updated, Advanced Male Urethral and Genital Reconstructive Surgery, Second Edition guides urologists in a practical manner on how to evaluate and manage complex urethral and male genital reconstructive challenges. Chapters have been added on wound healing, synchronous urethral strictures, non-transecting anastomotic urethroplasty (including muscle and vessel sparing), overlapping buccal grafts, male urethral slings, genital skin grafting, Peyronie’s surgery, priapism, pediatric strictures and prosthetics. Such chapters greatly strengthen the overall appeal of the book. The volume closes with a new comprehensive appendix of preferred instruments. With broad contributions by international authorities in reconstructive urologic surgery, Advanced Male Urethral and Genital Reconstructive Surgery, Second Edition is a valuable resource for all urologists, from residents to reconstructive surgeons.

This book summarizes the NATO Advanced Research Workshop (ARW) on “Nanoengineered Systems for Regenerative Medicine” that was organized under the auspices of the NATO Security through Science Program. I would like to thank NATO for supporting this workshop via a grant to the co-directors. The objective of ARW was to explore the various facets of regenerative me- cine and to highlight role of the “the nano-length scale” and “nano-scale systems” in defining and controlling cell and tissue environments. The development of novel tissue regenerative strategies require the integration of new insights emerging from studies of cell-matrix interactions, cellular signalling processes, developmental and systems biology, into biomaterials design, via a systems approach. The chapters in the book, written by the leading experts in their respective disciplines, cover a wide spectrum of topics ranging from stem cell biology, developmental biology, ce- matrix interactions, and matrix biology to surface science, materials processing and drug delivery. We hope the contents of the book will provoke the readership into developing regenerative medicine paradigms that combine these facets into cli- cally translatable solutions. This NATO meeting would not have been successful without the timely help of Dr. Ulrike Shastri, Sanjeet Rangarajan and Ms. Sabine Benner, who assisted in the organization and implementation of various elements of this meeting. Thanks are also due Dr. Fausto Pedrazzini and Ms. Alison Trapp at NATO HQ (Brussels, Belgium). The commitment and persistence of Ms.

An increased incidence of hypospadias is found globally, and the current management techniques and research studies of hypospadiology face significant challenges and limitations. This book sheds light on the recent struggles encountered in hypospadias-related clinical practice and research methodologies. Various writings were incorporated by people on different disciplines linked to the overall phases of diagnosis and care of hypospadias patients. Special attention is given to new perspectives from different interrelated disciplines trying to overcome these obstacles. This book fills in a void in the new related discoveries traditionally given scant consideration in the currently dominated literature. It provides a useful source for the recent updates, ongoing controversies, and future research trajectories in hypospadiology, which benefits pediatric, plastic, reconstructive, and urology surgeons and trainees and helps examiners focus on updated materials.

Regenerative Medicine in the Genitourinary System gives the reader a comprehensive overview of tissue engineering used to treat genitourinary disorders and infertility, also providing a great learning platform for researchers in different fields such as cell biology, pharmaceutics, clinicians, chemists, material scientists, and more. The book covers the latest innovations on the subject, but also acts as a resource for tissue engineering applications and regenerative medicine. Over the last several decades, tissue engineering has continued to make considerable advancements in therapeutic and clinical strategies that address male/female urological or genitourinary diseases. Although several articles have been published on this topic, there are very few book chapters and no single book currently available dedicated to this topic. - Provides extensive principles of tissue engineering in urinary and reproductive systems - Presents excellent examples of tissue engineering and regenerative medicine (translational medicine) to tackle diseases and disorders related to the urinogenital system - Includes chapters covering erectile disfunction, as well as tissue engineering strategies to treat male and female infertility

The notion of being able to engineer complete organs has inspired an entire generation of researchers. While recent years have brought significant progress in regenerative medicine and tissue engineering, the immense challenges encountered when trying to engineer an entire organ have to be acknowledged. Despite a good understanding of cell phenotypes, cellular niches and cell-to-biomaterial interactions, the formation of tissues composed of multiple cells remains highly challenging. Only a step-by-step approach will allow the future production of a living tissue construct ready for implantation and to augment organ function. In this book, expert authors present the current state of this approach. It offers a concise overview and serves as a great starting point for anyone interested in the application of tissue engineering or regenerative medicine for organ engineering. Each chapter contains a short overview including physiological and pathological changes as well as the current clinical need. The potential cell sources and suitable biomaterials for each organ type are discussed and possibilities to produce organ-like structures are illustrated. The ultimate goal is for the generated small tissues to unfold their full potential in vivo and to serve as a native tissue equivalent. By integrating and evolving, these implants will form functional tissue in-vivo. This book discusses the desired outcome by focusing on well-defined functional readouts. Each chapter addresses the status of clinical translations and closes with the discussion of current bottlenecks and an outlook for the coming years. A successful regenerative medicine approach could solve organ shortage by providing biological substitutes for clinical use - clearly, this merits a collaborative effort.

This textbook provides a guide to reconstructive surgery of genitourethral problems in male patients. The first section covers all aspects of urethral reconstruction, including the functional anatomy of the urethra, etiology, epidemiology, and demographic differences in urethral pathology. The second section focuses on surgical reconstruction of penile and scrotal anomalies and dysfunctions. Textbook of Male Genitourethral Reconstruction aims to aid the management of male genitourethral reconstruction patients by reviewing the recent advancements in technology and surgical technique. This book is relevant to urologists, plastic and reconstructive surgeons, medical students, and health care professionals working within urology and plastic surgery.Chapter “Tissue Transfer Techniques in the Management of Urethral Stricture Disease: Flaps and Grafts” is available open access under a Creative Commons Attribution 4.0 International License via link.springer.com.