Combat medic and biochemist Rebecca Chambers, the sole survivor of Bravo Team, joins a new S.T.A.R.S. strike force when rumor comes of another Umbrella experiment: hidden beneath the rocky cliffs of Caliban Cove, Maine, someone is building an army of the undead. Now the S.T.A.R.S. must battle more unspeakable horrors and stop a madman from unleashing the biohazard upon the world.

Sent to investigate a series of grisly murders in Racoon City, S.T.A.R.S Bravo Team scrambles into action. Following a helicopter crash, the team stumble across a gruesome sight: an overturned military transport truck riddled with corpses - and that’s only the beginning of their nightmare. As evil grows around them, rookie member Rebecca Chambers wonders what she’s gotten herself into.

Leon Kennedy, a rookie cop on a new assignment, and Claire Redfield, sister of the still-missing S.T.A.R.S. member Chris, arrive at Raccoon City to discover a necropolis. A botched attempt by the Umbrella Corporation to retrieve a devastating mutagenic weapon has resulted in a horrifying viral outbreak, transforming the city’s population into the living dead. And all of them are hungry.

Raccoon City: a remote mountain community suddenly besieged by a rash of grisly murders. At the epicenter, a dark secluded mansion belonging to the mysterious Umbrella Corporation. Deployed to investigate the strange goings-on is the Special Tactics and Rescue Squad (S.T.A.R.S.) but what unfolds as the team penetrate the mansion’s long-locked doors is terror beyond their worst nightmares.

A rookie cop and a resourceful young woman in search of her brother venture into Raccoon City on the very night that a horrifying viral outbreak has transformed every man, woman, and child into one of the living dead.

Beneath the deserts of the American Southwest, one of the Umbrella Corporation's most elaborate facilities is about to go online. Somewhere inside may also be the key to stopping Umbrella once and for all... can Leon Kennedy, Claire Redfield, Rebecca Chambers, and their friends can get past a strike team of corrupt S.T.A.R.S., and survive the genetically engineered horrors awaiting them?